Perception, Not Response: The Causes of Abnormal Audiovisual Conflict in Parkinson's disease patients

Perception, Not Response: The Causes of Abnormal Audiovisual Conflict in Parkinson's disease patients | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Perception, Not Response: The Causes of Abnormal Audiovisual Conflict in Parkinson's disease patients Heng Zhou, Yiqing Bao, Nan Zou, Guohua Fan, Hanbin Sang, Erlei Wang, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4279800/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 15 Apr, 2025 Read the published version in Scientific Reports → Version 1 posted 8 You are reading this latest preprint version Abstract Audiovisual conflict control is an important cognitive function in humans. However, it was not clear whether and how abnormal audiovisual conflict control was reflected at periods of perception and response in the cognitive process in Parkinson's disease (PD) patients. We recruited 27 PD patients and 22 healthy controls (HC) to complete audiovisual matching task to investigate the audiovisual conflict in PD patients at different processing periods and its relationship with cortical thickness. Behavioral results showed that abnormal audiovisual conflict at period of perception rather than response. The cortical thickness of left middle frontal gyrus (MFG) in PD patients was positively correlated with the sensory interference (visual interference > auditory interference) at period of perception. In addition, the results of support vector machines (SVM) showed revealed that models utilizing conflict at period of perception as a feature achieved higher predictive accuracy on the participant population, while those employing conflict at period of response as a feature did not. These finding suggested that perceptual conflict deficits in PD patients might be the causes of abnormal audiovisual conflict. Biological sciences/Psychology Biological sciences/Psychology/Human behaviour Parkinson's disease period of perception period of response audiovisual conflict cortical thickness Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 15 Apr, 2025 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 18 Oct, 2024 Reviews received at journal 16 Aug, 2024 Reviewers agreed at journal 07 Aug, 2024 Reviewers invited by journal 03 Jun, 2024 Editor assigned by journal 03 Jun, 2024 Editor invited by journal 16 May, 2024 Submission checks completed at journal 15 May, 2024 First submitted to journal 17 Apr, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4279800","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":305375037,"identity":"97baa66a-cc7b-4dd3-a793-cc9edfaec2f2","order_by":0,"name":"Heng Zhou","email":"","orcid":"","institution":"University of Chinese Academy of Sciences","correspondingAuthor":false,"prefix":"","firstName":"Heng","middleName":"","lastName":"Zhou","suffix":""},{"id":305375038,"identity":"88492d0d-964a-4bca-8f5e-5ca1bffd3660","order_by":1,"name":"Yiqing Bao","email":"","orcid":"","institution":"The Second Affiliated Hospital of Soochow 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