ANGIOGENIC IMBALANCE IN THE PATHOGENESIS OF THE LUTEAL PHASE INSUFFICIENCY IN WOMEN IN A REPRODUCTIVE AGE WITH PRIMARY OLIGOMENORRHEA IN PUBERTY

Д С Лысяк, D.S. Lysyak, Т С Быстрицкая, Tamara Bystrickaya, Константин Стокоз
In: Bulletin physiology and pathology of respiration · 2017 · vol. 1(65) , pp. 77–82 · doi:10.12737/article_59ace225ba1d55.79413042 · W2753300412
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study found that reduced angiogenic potential and an imbalanced angiogenic system in the ovary contribute to luteal phase insufficiency in reproductive-aged women with primary oligomenorrhea.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study examined angiogenic mechanisms in luteal phase insufficiency (LPI) among 30 reproductive-age women with primary oligomenorrhea in puberty, compared with 30 healthy controls, using serum VEGF and VEGFR1 (sVEGFR1) levels and Doppler ultrasound measurements of ovarian arterial and stromal blood flow. The authors report that 10 women (within the oligomenorrhea group) had ovulatory cycles accompanied by LPI, characterized by a ~1.7-fold lower serum progesterone level, and in these women VEGF concentration and the VEGF/VEGFR1 angiogenic coefficient were about twofold lower than in controls and women with a full luteal phase. They also found reduced blood flow velocities in the ovarian artery and stromal vessels on the dominant-follicle side, and developed a predictive model suggesting that reduced angiogenic potential and an imbalance in the ovarian angiogenic system contribute to LPI. A stated limitation is that women with conditions including endometriosis were excluded from the study. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via exclusion criteria that mention endometriosis.

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Abstract

The purpose of the research was to study the role of the angiogenic system in the pathogenesis of the luteal phase insufficiency in women in reproductive age with primary oligomenorrhea in the pubertal period. In a comparative aspect with healthy women (the control group), the hemodynamics in the ovarian arteries and in the arteries of the ovarian stroma in 30 women in reproductive age with primary oligomenorrhea in the pubertal period (the study group) was studied. The angiogenic system was studied by the indices of the vascular endothelial growth factor (VEGF) and its receptor (VEGFR1) in the blood serum. It was found out that in 10 women of the studied group the ovulatory menstrual cycle was accompanied by luteal phase insufficiency; the serum progesterone concentration was 1.7 times lower (27.41±3.10 nmol/L) than in the control group (47.64±4.19 nmol/L, p<0.001). In women with luteal phase insufficiency, the VEGF concentration (11.17±6.18 pg/ml) and the angiogenic coefficient of VEGF/VEGFR1 (0.76) were 2 times lower than in the control group (209.06±20.41 pg/ml; 1.52) and in women with primary oligomenorrhea in the pubertal period with a full luteal phase (237.98±24.67 pg/mL; 1.44). The blood flow velocities in the ovarian artery and in the vessels of the ovarian stroma with the dominant follicle did not differ from the parameters of the opposite ovary and were lower in comparison with those of the control group. A model for predicting the formation of a functionally active yellow body has been developed. Thus, the reduction of the angiogenic potential and imbalance in the angiogenic ovary system with a dominant follicle is one of the links in the pathogenesis of luteal phase insufficiency in women in reproductive age with primary oligomenorrhea in the pubertal period. 2 times increase of the VEGF concentration and of angiogenic coefficient by more than 1.0 provides adequate angiogenesis in the dominant follicle and the formation of a full-valued yellow body.

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