Gestrinone combined with gonadotropin-releasing hormone agonist for endometriosis

Objective To observe the clinical efficacy of gonadotropin-releasing hormone agonist ( GnRH-a ) combined with gestrinone in the treatment of endometriosis.Methods 80 patients with endometriosis were randomly assigned to receive gestrinone combined with GnRH-a ( study group ),or GnRH-a alone ( control group ).The symptoms,signs, and findings of pelvic ultrasonic examination were observed and analyzed.Results In the study group, 36 patients were cured,3 had symptom relief,and one developed relapse,whereas 29 patients were cured,9 had symptom relief,and 2 occurred relapse in the control group,with a significant difference ( P＜ 0.05 ).The rate of adverse reactions including vaginal bleeding and ALT elevation differed significantly between the two groups ( P＜ 0.05 ).As compared with the baselines,levels of FSH,LH,and E2 declined significantly in the study group ( P＜ 0.05 ) but did not change significantly in the control group ( P ＞ 0.05 ).Conclusions Gestrinone combined with GnRH-a can effectively improve the therapeutic effect and can reduce the rates of relapse rate and adverse reactions.It ias a valuable therapy. Key words: Gestrinone;  Gonadotropin-releasing hormone agonist;  Endometriosis;  Clinical research