Rapid Progression and Poor Prognosis in Endometrioid Ovarian Cancer Arising from Endometrioma: A Case Report

Rapid Progression and Poor Prognosis in Endometrioid Ovarian Cancer Arising from Endometrioma: A Case Report DOI: https://doi.org/10.69614/ejrh.v17i3.931Keywords: Endometriosis, Endometriosis associated ovarian cancer, Ovarian cancerAbstract Endometriosis is linked to an increased risk of endometrioid ovarian cancer, though malignant transformation is rare. We report a 35-year-old nulliparous woman with a 12-year history of endometriosis who developed endometrioid ovarian cancer two months after her last surgery. Histological examination initially showed no malignancy, but subsequent immunohistochemical analysis confirmed cancer. The patient underwent surgery followed by six cycles of platinum-taxane chemotherapy. This case underscores the need for thorough assessment in rapidly progressing endometriosis. References Matalliotakis M, Matalliotaki C, Goulielmos GN, Patelarou E, Tzardi M, Spandidos DA, et al. Association between ovarian cancer and advanced endometriosis. Oncol Lett. 2018 May 1: 15(5):7689–92. Available from: http://www.spandidos-publications.com/10.3892/ol.2018.8287/abstract Dahiya A, Sebastian A, Thomas A, George R, Thomas V, Peedicayil A. Endometriosis and malignancy: The intriguing relationship. International Journal of Gynecology & Obstetrics. 2021 Oct 1;155(1):72–8. Kuo HH, Huang CY, Ueng SH, Huang KG, Lee CL, Yen CF. Unexpected epithelial ovarian cancers arising from presumed endometrioma: A 10-year retrospective analysis. Taiwan J Obstet Gynecol. 2017 Feb 1;56(1):55–61. Negrão E, Flor-de-Lima B, Duarte AL, Braga AC, Portugal R, Madureira AJ. Ovarian clear cell carcinoma arising in a large endometrioma — A case report with pathological correlation and literature review. Radiol Case Rep. 2022 Aug 1;17(8):2806–11. Robinson KA, Menias CO, Chen L, Schiappacasse G, Shaaban AM, Caserta MP, et al. Understanding malignant transformation of endometriosis: imaging features with pathologic correlation. Abdominal Radiolog. 2020 Jun 1; 45(6):1762–75. Taniguchi F, Harada T, Kobayashi H, Hayashi K, Momoeda M, Terakawa N. Clinical Characteristics of Patients in Japan with Ovarian Cancer Presumably Arising from Ovarian Endometrioma. Gynecol Obstet Invest. 2014; 77(2):104–10. Bartiromo L, Schimberni M, Villanacci R, Mangili G, Ferrari S, Ottolina J, et al. A Systematic Review of Atypical Endometriosis-Associated Biomarkers. Int J Mol Sci [Internet]. 2022 Apr 1; 23(8):4425. Lai CR, Hsu CY, Chen YJ, Yen MS, Chao KC, Li AFY. Ovarian cancers arising from endometriosis: A microenvironmental biomarker study including ER, HNF1ß, p53, PTEN, BAF250a, and COX-2. Journal of the Chinese Medical Association. 2013 Nov;76(11):629–34. Penciu RC, Postolache I, Steriu L, Izvoranu S, Tica AA, Mocanu ID, et al. Is there a relationship in-between ovarian endometriosis and ovarian cancer? Immunohistochemical profile of four cases with coexisting ovarian endometriosis and cancer. Romanian Journal of Morphology and Embryology. 2020: 61(1):157. Pramanik R, Gupta R, Suvvari P, Mishra S. Management of Complications and Toxicities Related to Chemotherapy in ICU. 2022;279–91. Available from: https://link.springer.com/chapter/10.1007/978-981-16-9929-0_25