To Explore the Association Between Coagulation Function and Cerebral Microbleeds in Patients With Intracerebral Hemorrhage

Abstract Object:To verify the association between coagulation function and cerebral microbleeds(CMBs) in patients with intracerebral hemorrhage(ICH).Methods: A total of 193 patients underwent 3.0T magnetic resonance image(MRI) and were found ICH,they were divided into CMBs and non-CMBs groups. Indicators of coagulation function and some other flood and clinical data like prothrombin time (PT), activated partial thromboplastin time(APTT), international normalized ratio (INR) were enrolled.univariate and multivariate analysis were used to compare the difference between the two groups and screen risk factors. One or more receiver operating characteristic(ROC) curve were used to present the predictive value of the indicators for CMBs.Result: After a univariate analysis, the result showed that INR levels was significantly higher in the CMBs group than the non-CMBs group [1.06 (0.96, 1.12) vs. 0.97 (0.93, 1.03);P= 0.035), while there was no significant difference between PT, APTT, TT and FBI. To compare the baseline characteristic of the two groups showed that the age ,the proportion of a history of long-term antithrombotic treatment(AT), history of ischemic stroke(IS) and combination with a brain atrophy(BA) cases in the CMBs group was significantly higher than the non-CMBs group(each P < 0.05). Multivariate logistic regression analysis showed that age and IS were independent risk factors for CMBs in patients with ICH (OR:0.967, 95% CI: 0.936-0.998, P = 0.036; OR:2.016, 95% CI: 1.090-3.991,P = 0.044; respectively). ROC curves indicated that the area under curve(AUC) of age and IS for CMBs in patients with ICH was 0.610(95%CI:51.76%-70.32%) and 0.619(95%CI:53.32%-68.87%), respectively.Conclusion:Age and IS were the independent risk factor for CMBs in patients with ICH, among the coagulant indicators, INR showed a significantly higher level in the CMBs group than the non-CMBs group.