Are The 50’s, The Transition Decade in Choroid Plexus Aging?

Abstract Background: The choroid plexus (CP) is an important structure for the brain. Besides its major role in the production of cerebrospinal fluid (CSF), it conveys signals originating from the brain and from the circulation, therefore shaping brain function in health and in pathology. In accordance, previous studies in rodents revealed altered transcriptome during aging and in various diseases of the central nervous system including Alzheimer’s disease. Methods: In the present study we performed a high-throughput sequencing of the CP transcriptome in clinically healthy humans throughout aging, from the ages of 50’s years into the 80's. Results: The date shows an age-related profile, with the main changes occurring in the transition from the 50 ́s to the 60’s, stabilizing thereafter. Specifically, neuronal and membrane functions distinguish the transcriptome between the 50’s and the 60’s, while neuronal and axon development and extracellular structure organization differentiate the 50’s from the 70’s. Conclusions: These findings suggest that changes in the CP transcriptome occur early in the aging process and may precede later onset brain disabilities, associated with memory and cognitive impairment.