The relationship between intra-amniotic sludge and the amniotic fluid proteome in a cohort of pregnant women with acute cervical insufficiency.

From 10 patients with acute cervical insufficiency and prospectively collected amniotic fluid, the relationship between intra-amniotic sludge (IAS) and proteomic profile is described. An abundance of keratinizing proteins were seen with IAS; without sludge, inflammatory proteins were predominant. Proteomic profiling may provide unique insights into management of these high-risk pregnancies.