Clinical study on hysteroscopic endometrial resection combined with gestrinone for treatment of adenomyosis

Objective:To explore the clinical value of hysteroscopic endometrial resection combined with gestrinone for treatment of adenomyosis.Methods:Sixty-three patients with adenomyosis were randomly divided into study group(42 patients) and control group(21 patients).The patients in the two groups were treated with transcervical resection of endometrium(TCRE) to resect basement membrane and partial muscular tissue of endometrium,the patients in study group were also treated with gestrinone for 12 months.All the patients in the two groups were followed up for 24 months after TCRE;the menstrual volumes,hemoglobin levels,dysmenorrheal scores,uterine volumes,blood CA125 levels,recurrence rates,and complications in the two groups were observed.Results:There were statistically significant differences in menstrual volume,hemoglobin level,dysmenorrheal score,uterine volume between study group and control group(P0.01),the degree of reduction of uterine volume in study group was statistically significantly higher than that in control group(P0.01),there was statistically significant difference in decreasing value of blood CA125 between the two groups(P0.01);the recurrence rate in study group was 50.00%,which was statistically significantly lower than that in control group(13.97%)(P0.01).The major complication in study group was gestrinone-induced mild dysfunction of liver.Conclusion:Hysteroscopic endometrial resection combined with gestrinone is safe for treatment of adenomyosis,the curative effect is dominant,and the recurrence rate is low,which is an effective method for conservative treatment of adenomyosis.