The Effectiveness of Inflammatory Indexes in Assessing Oropharyngeal Cancer Prognosis

The Effectiveness of Inflammatory Indexes in Assessing Oropharyngeal Cancer Prognosis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article The Effectiveness of Inflammatory Indexes in Assessing Oropharyngeal Cancer Prognosis Wooyoung Jang, Jad F. Zeitouni, Daniel K. Nguyen, Ismail S. Mohiuddin, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3830223/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Inflammation has long been a key tenet in the diagnosis and management of malignancies, likely contributing to cancer incidence, staging, and progression. Systemic inflammation, in particular, is often elevated prior to and during cancer development. Systemic inflammation in the context of cancer diagnosis and monitoring is measured by various inflammatory indexes such as Systemic inflammatory response index (SIRI), plasma-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and neutrophil-to-lymphocyte ratio (NLR). We set out to determine the relationship between pre and posttreatment levels of these inflammatory indexes and the prognosis and outcomes of oropharyngeal cancer (OPC). Methods A retrospective chart review was performed of 172 patients with OPC who underwent treatment for oropharyngeal cancer at University Medical Center between May 2013 to May 2023. Sites of primary cancer were obtained through chart review. HPV infection status and differentiation of the tumor were noted for each patient. Treatment modalities were classified as surgery, radiation, chemotherapy, or concurrent chemotherapy and radiation. Treatment outcomes were classified based on recurrence and death secondary to disease. The relationships between treatment outcome and the described inflammatory indexes were evaluated. Appropriate parametric tests were selected based on the large number of variables. Results Pretreatment SIRI and Albumin levels were positively predictive in determining locoregional recurrence (p = .031 and p = .039). NLR, SII, and SIRI levels taken at three months post-treatment were also found to be positively predictive of locoregional recurrence (p = .005, p > .0005, and p = .007). SIRI taken at six months post-treatment was also found to be positively predictive of locoregional recurrence (p = .008). SII at six months post-treatment was found to be positively predictive of survival (p = .027). Conclusions This study suggested that post-treatment levels of several inflammatory indexes, particularly SIRI, NLR, and SII, may be useful in determining the long-term outlook and recurrence of head and neck cancer following treatment. Oropharyngeal Cancer Inflammatory Index Cancer Survival Figures Figure 1 Figure 2 Figure 3 Figure 4 Introduction Inflammation has long been a key tenet in the diagnosis and management of malignancies, likely contributing to cancer incidence, staging, and progression. 1 , 2 Systemic inflammation, in particular, is often elevated prior to and during cancer development. 1 Systemic inflammation in the context of cancer diagnosis and monitoring is measured by various inflammatory indexes such as Systemic inflammatory response index (SIRI), plasma-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and neutrophil-to-lymphocyte ratio (NLR). There is robust literature showing the elevation of various inflammatory indexes in different cancers. There have been several studies in the literature examining the relationship between the aforementioned inflammatory indexes and various types of different. The neutrophil to lymphocyte ratio (NLR) has been shown in several studies to be a biomarker associated with decreased survival and prognosis in several solid tumor cancers. 3 Higher NLR has been associated with increased tumor growth and prognosis in various cancers of the gastrointestinal system. 4 – 6 Elevated NLR has also been shown to be an indicator of poor prognosis in squamous cell carcinoma of the head and neck. 7 Elevated platelet-to-lymphocyte ratios (PLR) have also been correlated with poor prognosis in a host of different cancers, including melanoma, rectal, and hepatocellular carcinoma. 6 , 8 , 9 SIRI is an inflammatory index that is based on the ratio of neutrophil count, monocyte count, and lymphocyte count. 10 Several studies have shown that SIRI is an important inflammatory index in the progression of many tumors. 10 It was shown to be an independent prognosis indicator in gallbladder cancer. 11 It was also been shown to be a prognostic biomarker in squamous cell carcinoma of the head and neck. 12 Elevated systemic Immune inflammation index (SII) has been an indicator of poor prognosis in patients treated with immune checkpoint inhibitors immunotherapy. 13 Elevated SII has been associated with poor prognosis in several malignancies, including bladder and non-small cell lung cancer. 14 , 15 Oropharyngeal cancer is one of the most common malignancies worldwide and the 7th leading cause of cancer deaths worldwide. 16 OPC is associated with tobacco use, alcohol consumption, and human papillomavirus (HPV). 16 Additionally, OPC, particularly HPV-associated OPC, has been on the rise in the united states. 16 The literature regarding the association of the various inflammatory indexes and prognosis of various malignancies is quite robust; however, oropharyngeal cancer (OPC) has been sparsely explored in this area. Furthermore, exploring and comparing which inflammatory indexes are the best determinates of outcome and prognosis in OPC is an emerging area in the literature that we set out to explore. We set out to determine the relationship between the SIRI, PLR, SII, and NLR inflammatory indexes and the prognosis and outcomes of OPC. Additionally, we wanted to determine which indexes are the most significant prognosis indicators of OPC. We conducted a single institution retrospective chart review of 172 patients with OPC and evaluated their inflammatory index levels. Material/methods With approval from the Texas Tech University Health Sciences Center Internal Review Board, a retrospective chart review identified 172 patients who underwent treatment for oropharyngeal cancer from May 9 2013 to May 9 2023. Patients who did not have any available pre-treatment and post treatment blood work to analyze and those who did not have greater than 3 months of follow-up post-treatment were excluded. Basic demographic information, such as gender, age, BMI, and ethnicity, as well as identified risk factors, such as smoking and alcohol use, were gathered (Table 1). Sites of primary cancer were obtained through chart review, which was classified as tonsil, base of tongue, soft palate, posterior, and overlapping. Furthermore, HPV infection status (positive, negative, n/a) and differentiation of the tumor (well, moderate, poor, undifferentiated) were noted for each patient. Tumor staging was recorded according to the 7th and 8th editions of oropharyngeal cancer staging according to the American Cancer Society. Treatment intent was tabulated as either curative or palliative therapy, with the treatment modalities classified as surgery, radiation, chemotherapy, or concurrent chemotherapy and radiation. Patients who received adjuvant treatments were also noted. Post-treatment margin status was noted as either negative, positive, or n/a, and treatment outcomes were classified based on recurrence and death secondary to disease. If recurrence was observed, the location was noted as either the primary site, neck, both, or not specified. The relationships between treatment outcome and pre and posttreatment levels of inflammatory indexes such as systemic inflammatory response index (SIRI), plasma-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and neutrophil-to-lymphocyte ratio (NLR) were evaluated. Statistical analysis was performed using SPSS (Version 23, IBM, USA). Multiple testing was used based on the large number of variables. Descriptive statistics were performed by independent t-tests and the Mann-Whiney U-test for mean comparisons of variables with two groupings. For variables with groupings of three or more a one-way ANOVA (analysis of variance) test was utilized. Chi-squared and Fisher’s exact tests were used to analyze categorical variables. Univariate survival estimates were generated by the Kaplan-Meier method and compared with the log-rank test. Multivariate survival analysis was performed using the Cox proportional hazard regression model, utilizing all variables approaching significance (p 0.2) to control for confounding covariates. All tests were two-tailed, and results were considered significant for p 0.05. Results Initial screening revealed with 263 patients and 91patient were excluded from the study because of either lack of blood work or appropriate follow up. As shown in Table 1, the demographics for the final cohort included 172 patients, 79.1% male and 20.9% female. Most patients identified as Caucasian (86%) and 2.9% identified as black. 46.5% of the patients had a smoking history of more than 10 pack years, 14% that of less than 10 pack years and 39.5% had no previous smoking history. In regard to alcohol history, 48.3% denied any alcohol use while 30.8% drank socially and 20.9% drank heavily. The most common site for oropharyngeal cancer was BOT, at 44.2%, followed by the tonsil (27.9%), overlapping (16.3%), posterior (6.4%), and soft palate (5.2%). HPV status was divided into positive (37.7%), negative (30.3%), and N/A (30.3%) and differentiation status into well (6.4%), moderate (36.0%), poor (27.3%), and undifferentiated (30.2%). Tumor staging was divided according to the 7th and 8th editions according to American cancer society as shown in Table 2 and showed relatively even distribution of patients. Table 3 describes the treatment intent and outcomes, which showed that for 94.2% of patients, the goal of treatment was curative, with surgery (57.6%) employed as the most common primary treatment, followed by chemotherapy and radiation combined (39.0%) . Chemotherapy and radiation combined (50%) was the most common neoadjuvant treatment. Following treatment, 23.8% of the total patients had recurrence of disease with local recurrence at the neck being the most common (35%) followed by the primary site (32.5%), both (25%), and unspecified (7.5%). In total, 59 patients (34.3%) died and of those, 26 patients (44.1%) died due to disease. Table 4 shows the pre-treatment, 3 month, and 6 month mean values of the inflammatory markers SIRI, PLR, SII, NLR, and PNI values divided according to sex, ethnicity, smoking and alcohol history, location of tumor, HPV status, tumor differentiation, AJCC staging (7th and 8th edition), treatment intent, primary treatment, adjuvant treatment, margin status, recurrence, location of recurrence, and death. Of these values, we found that pretreatment SIRI and Albumin levels were positively predictive in determining locoregional recurrence (p=.031 and p=.039). NLR, SII, and SIRI levels taken at three months post-treatment were also found to be positively predictive of locoregional recurrence (p=.005, p<.0005, and p=.007), as well as SIRI taken at six months post-treatment (p=.008). Lastly, SII at six months post-treatment was positively predictive of survival (p=.027). Figures 1, 2, 3, and 4 summarize survival outcomes on Kaplan-Meier Curves. Decreased inflammatory markers are associated with improved survival outcomes on Kaplan-Meier Curves. However, only SII at six months post-treatment value was statistically significant on the Cox proportional hazard test (p=.027). Discussion This retrospective project aimed to evaluate the role the inflammatory indexes of SIRI, PLR, SII, NLR, and PNI have on Head and Neck cancer prognosis. These inflammatory indexes have been well described in the literature in the context of cancer incidence and prognosis. 1 – 2 , 8 There has not been a definitive consensus in the literature on the role and prognosis value of inflammatory indexes in head and neck cancer. 17 Other effective prognosis indicators in Head and neck cancer include TNM (Tumor, Node, Metastasis) staging and HPV-positive status of head and neck cancer. 18 SIRI is calculated by multiplying neutrophils by the ratio of monocytes/lymphocytes. 12 SIRI has been shown to be an independent predictor disease specific survival in head and neck squamous cell carcinoma. 12 SIRI was also shown to be a predictor in local, regional, and distant recurrence-free survival. 12 It is seen as an effective prognosis indicator in head and neck cancers. 18 On that note, our findings on SIRI were particularly robust regarding locoregional recurrence. We found that pretreatment SIRI was positively predictive in determining locoregional recurrence (p = .031). SIRI taken at three months post-treatment was also found to be positively predictive of locoregional recurrence ( p = .007). Finally, SIRI taken at six months post-treatment was also found to be positively predictive of locoregional recurrence (p = .008). This is consistent with the previous literature stating that pretreatment SIRI levels are a predictor in local and regional recurrence-fee survival. 12 This study builds on the existing literature by showing SIRI taken at 3-month and 6-month intervals after treatment was significantly predictive with locoregional recurrence. SII is calculated by multiplying platelet count by neutrophil count/lymphocyte count. 19 SII has been used as a prognosis predictor in several cancers, including cervical, colorectal, bladder, lung, and liver cancer. 19 A high SII in head and neck cancer patients prior to receiving treatment has been shown to be predictive of decreased overall survival and more advanced tumor status. 12 SII levels taken at three months post-treatment was found to be highly predictive of locoregional recurrence ( p > .0005). Additionally, SII at six months post-treatment was found to be positively predictive of survival (p = .027). Our results did not show significance the prognosis effectiveness in pretreatment levels of SII. However, we were able to show significance using post-treatment SII levels in both recurrence (taken at 3 months post treatment) and survival (taken at 6 months post treatment). NLR, which is the neutrophil to lymphocyte ratio, and PLR, which is the platelet to lymphocyte ratio, are inflammatory markers that have been shown to have prognostic value in several cancers. 20 Higher pretreatment PLR and NLR values have been shown to be associated with poor survivability in pancreatic, gastrointestinal, bladder, and ovarian cancers. 20 Elevated pretreatment PLR and NLR have been associated with poor survivability in head and neck cancer patients, regardless of treatment modality (surgery or chemotherapy). 20 NLR llevels taken at three months post-treatment were also found to be positively predictive of locoregional recurrence (p = .005). Again, we did not find significance with the pretreatment levels NLR, which the majority of the existing literature focuses on. We did, however, find significance, in the 3 month post-treatment NLR level. It should be noted that we did not find significance in both pretreatment and posttreatment levels of NLR. Finally, PNI, which is the Prognostic Nutritional Index, is calculated by the serum albumin concentration and the total lymphocyte count in the peripheral blood. 21 Low PNI has been shown to be associated with worse overall survival in patients with esophageal cancer. 21 Low PNI has been shown to be significantly associated with poor overall survival in patients with head and neck cancer, but it was not a significant indicator of disease-specific survival. 22 Pretreatment albumin levels was found to be positively predictive in determining locoregional recurrence ( p = 0.039). This is in line with the previous literature. The limitations of this study are that it is a single-center retrospective chart review and our cohort size of 172 patients. Our study was underpowered to find significance for pretreatment levels of several of the inflammatory indexes in locoregional recurrence and overall survival. Aside from these limitations, this study signifies a notable addition to the literature that signifies the value of post-treatment levels of inflammatory indexes as a prognosis and recurrence indicator in head and neck cancer. This study built on the existing literature showing the value of inflammatory indexes as a prognosis indicator in head and neck cancer. Much of the literature has focused on utilizing pretreatment levels of inflammatory indexes; this study uniquely examined both pretreatment and posttreatment (measured at three and six months intervals). Additionally, this study also demonstrates the value of using inflammatory indexes to evaluate locoregional tumor recurrence in head and neck cancer. SIRI and Albumin pretreatment levels were the only indexes shown to have predictive value in locoregional recurrence. SIRI taken at both three and six-month post-treatment was also found to be predictive of locoregional recurrence. NLR and SII at three months posttreatment were found to be predictive of locoregional recurrence. SII was the only inflammatory index to show a significant correlation with post-treatment levels and overall survival. Overall, we have uniquely highlighted the value post-treatment inflammatory indexes may have as prognosis and locoregional indicators for head and neck cancer. Conclusion This study suggested that post-treatment levels of several inflammatory indexes, particularly SIRI, NLR, and SII, may be useful in determining long-term outlook and recurrence of head and neck cancer following treatment. This builds on the existing literature that primarily focuses on pretreatment levels of inflammatory indexes and their prognosis value for overall survival. Additionally, it highlights the need for future studies to further evaluate the role posttreatment inflammatory index levels have on future recurrence and overall prognosis of head and neck cancer. Also, inflammatory markers of those patient received immunotherapy regimens may help to understand pathophysiology of disease would be very interesting and helpful. Declarations Funding: None Conflicts of interest: None Author Contribution W.J.: Manuscript draft and editsJ.Z.: Manuscript draft and editsD.N.: Data CollectionI.M.: Data CollectionH.W. Data CollectionA.S.: Data CollectionY.D.: Statistical Analysis, Manuscript edits References Nøst TH, Alcala K, Urbarova I, et al. Systemic inflammation markers and cancer incidence in the UK Biobank. Eur J Epidemiol . Aug 2021;36(8):841-848. doi:10.1007/s10654-021-00752-6 Diakos CI, Charles KA, McMillan DC, Clarke SJ. Cancer-related inflammation and treatment effectiveness. Lancet Oncol . Oct 2014;15(11):e493-503. doi:10.1016/s1470-2045(14)70263-3 Templeton AJ, McNamara MG, Šeruga B, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst . 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Eur Arch Otorhinolaryngol . 2023;280(8):3821-3830. doi:10.1007/s00405-023-07954-6 Tables Number Percent Gender Male Female 136 36 79.1% 20.9% Ethnicity Caucasian Black Hispanic or other 148 5 19 86.0% 2.9% 11.0% Smoking No Less than 10 packs More than 10 packs 68 24 80 39.5% 14.0% 46.5% Alcohol No Socially Heavily 83 53 36 48.3% 30.8% 20.9% Site Tonsil BOT Soft Palate Posterior Overlapping 48 76 9 11 28 27.9% 44.2% 5.2% 6.4% 16.3% HPV Positive Negative N/A 66 53 53 37.7% 30.3% 30.3% Differentiation Well Moderate Poor Undifferentiated 11 62 47 52 6.4% 36.0% 27.3% 30.2% Table 1: Patient Demographics Number Percentage T staging (7 th edition) T1 T2 T3 T4 24 44 62 42 14.0% 25.6% 36.0% 24.4% N staging (7 th edition) N0 N1 N2a N2b N2c N3a N3b 31 36 23 39 16 20 7 18.0% 20.9% 13.4% 22.7% 9.3% 11.6% 4.1% M staging (7 th edition) M0 M1 Mx 119 11 42 69.2% 6.4% 24.4% T staging (8 th edition) T1 T2 T3 T4 24 44 62 42 14.0% 25.6% 36.0% 24.4% N staging (8 th edition) N0 N1 (P16 -) N2a (P16 -) N2b (P16 -) N2c (P16 -) N3a (P16 -) N3b (P16 -) N1 (P16 +) N2 (P16 +) N3 (P16 +) Nx 31 24 10 24 10 11 3 20 27 9 3 18.0% 14.0% 5.8% 14.0% 5.8% 6.4% 1.7% 11.6% 15.7% 5.2% 1.7% M staging (8 th edition) M0 M1 Mx 119 11 42 69.2% 6.4% 24.4% Table 2: Tumor Staging Number Percentage Treatment Intent Curative Palliative 162 10 94.2% 5.8% Primary Treatment Chemo/Radiation Surgery Radiation Chemotherapy 67 99 4 2 39.0% 57.6% 2.3% 1.2% Adjuvant Treatment None Chemo/Radiation Surgery Radiation Chemotherapy 66 86 9 7 4 38.4% 50.0% 5.2% 4.1% 2.3% Margin Status Negative N/A Positive 32 79 61 18.6% 45.9% 35.5% Recurrence No Yes N/A 78 41 53 45.3% 23.8% 30.8% Local Recurrence Primary Site Neck Both Not specified 13 14 10 3 32.5% 35.0% 25.0% 7.5% Death Yes No 59 113 34.3% 65.7% Death Due to Disease Yes No 26 33 44.1% 55.9% Table 3: Treatments and oncologic outcomes SIRI PLR SII NLR PNI Pre- Treatment 3 months 6 months Pre- Treatment 3 months 6 months Pre- Treatment 3 months 6 months Pre- Treatment 3 months 6 months Pre-Treatment Sex Male (n:58) 24.02 45.60 32.49 97.68 256.11 201.77 1199.37 2768.84 2382.91 4.78 10.47 9.38 25.50 Female (n:13) 25.70 19.39 29.83 192.44 242.84 112.38 2361.78 1764.03 1145.61 7.87 6.17 5.07 25.58 Ethnicity Caucasian 24.29 40.86 33.25 117.49 275.14 199.92 1374.44 2443.75 2332.70 5.32 8.96 9.25 27.33 Black 24.04 33.07 26.87 13.36 8.48 5.97 871.19 550.10 390.07 2.60 3.09 2.89 22.73 Hispanic or other 24.99 42.58 18.26 154.50 85.49 73.23 2156.84 4238.48 737.31 7.51 17.67 2.89 12.33 Smoking Non Smoker 26.14 58.19 29.57 74.50 154.08 130.45 1497.93 2463.81 2380.28 5.79 12.52 12.15 24.69 10 19.21 34.96 34.54 143.63 304.79 229.24 1326.05 2626.25 2229.28 4.80 8.33 7.39 26.25 Alcohol No Alcohol 29.23 60.87 43.60 57.79 158.41 86.25 1398.34 2733.73 1434.51 5.71 11.04 5.92 23.21 Social 29.05 28.94 20.11 137.16 252.52 266.81 1334.03 2210.38 3598.18 5.31 9.34 13.77 25.35 Heavy 13.58 18.39 26.73 168.58 445.44 259.73 1501.55 2824.19 1894.26 4.91 7.65 7.76 30.94 Location of Tumor Tonsil 17.00 37.12 33.24 66.70 198.38 117.00 763.31 1661.65 1130.60 3.18 7.50 5.47 23.86 BOT 15.50 38.36 30.87 126.10 189.46 192.35 1025.94 2126.21 2825.55 3.87 9.30 10.56 26.54 Soft Palate 40.46 25.33 28.89 67.00 338.34 7.28 1313.13 2055.45 488.15 6.47 10.56 3.28 22.04 Posterior 35.99 99.31 31.37 194.31 312.01 278.25 3489.36 8285.52 1615.26 12.13 23.67 7.03 23.75 Overlap 41.03 31.60 37.14 127.81 579.27 452.68 2169.05 3695.78 3532.29 7.75 8.11 13.72 27.27 HPV Positive 25.12 37.28 27.75 100.77 189.38 170.72 1376.81 1696.25 2285.45 5.73 7.02 9.28 28.01 Negative 28.62 46.87 39.48 75.22 329.76 154.66 1256.59 3490.03 1538.60 5.06 12.24 6.39 23.51 n/a 17.78 41.04 35.52 184.46 289.60 257.41 1658.75 3317.86 2538.07 5.26 12.12 9.39 24.51 Differentiation Well 62.30 7.98 .3636 75.94 1392.63 155.45 2459.24 6017.02 310.91 9.15 4.50 1.82 32.03 Moderate 28.71 37.46 29.44 116.78 103.07 187.14 1646.38 1495.39 3124.95 6.49 5.60 11.80 21.27 Poor 18.73 50.83 41.57 95.20 252.88 154.50 1205.46 2881.12 1719.40 4.50 11.02 6.81 23.78 Undifferentiated 14.85 38.32 27.68 137.21 256.19 222.52 1081.09 2933.54 1596.62 3.95 13.13 7.11 30.79 AJCC 7 Staging T1 37.53 34.45 32.72 86.59 428.64 12.51 3057.45 2544.49 835.32 28.33 4.68 3.50 13.81 T2 6.34 33.34 12.77 131.98 185.00 162.98 797.70 2251.12 682.30 3.52 8.58 3.99 28.33 T3 29.58 46.59 44.46 97.09 163.27 125.39 1264.57 2156.40 2832.00 4.87 9.60 12.18 27.28 T4 24.21 45.75 33.05 135.52 373.51 373.49 1527.93 3672.62 3256.58 5.28 14.23 10.07 26.79 N0 29.75 23.77 32.89 95.57 522.64 113.56 1512.05 2870.39 6088.58 5.90 6.15 30.28 25.34 N1 24.99 16.57 13.18 131.94 285.60 163.20 1712.47 1691.06 786.07 6.37 6.59 4.36 27.47 N2a 11.54 44.93 33.54 99.86 94.17 235.17 795.79 1225.86 2370.51 3.42 5.92 6.35 18.52 N2b 22.95 44.66 15.78 140.03 178.07 312.86 1392.75 3041.01 2016.61 5.11 14.69 7.60 25.04 N2c 33.07 68.57 84.92 102.17 44.39 31.50 1579.58 2189.85 2529.08 5.55 7.49 9.09 29.87 N3a 24.03 70.00 27.41 105.88 493.27 221.04 1314.31 6382.21 1580.05 4.93 20.30 7.14 30.37 Nx 21.10 24.07 19.07 126.49 341.33 147.16 1439.00 1156.37 1025.47 6.86 4.75 5.03 17.86 M0 20.98 29.86 33.77 117.54 298.81 202.49 1349.87 2026.73 1715.13 5.23 7.57 7.16 27.43 M1 41.20 158.62 28.41 38.96 169.04 7.48 1013.05 9684.81 492.24 5.18 29.81 3.29 25.51 Mx 26.06 62.22 27.73 144.46 71.39 169.99 1824.58 3421.94 3765.54 5.84 14.44 13.82 20.19 AJCC 8 Staging T1 37.54 34.45 32.72 86.59 428.64 12.51 3057.45 2544.49 835.32 11.98 4.68 3.50 13.81 T2 6.34 33.34 12.77 131.98 185.00 162.98 797.70 2251.12 682.30 3.52 8.58 3.99 28.33 T3 29.58 46.59 44.46 97.09 163.27 125.39 1264.57 2156.40 2832.00 4.87 9.60 12.18 27.28 T4 24.21 45.75 33.05 135.52 373.51 373.49 1527.93 3672.62 3256.58 5.28 14.23 10.07 26.79 N0 29.75 23.77 32.89 95.57 522.64 113.56 1512.05 2870.39 6088.58 5.90 6.15 30.28 25.34 N1 12.50 15.07 14.19 220.35 355.47 252.51 1246.60 2009.14 1110.16 3.81 7.76 6.40 22.60 N2a 10.41 47.67 41.52 64.33 91.21 153.71 1080.14 1444.49 1637.63 4.23 6.00 5.57 11.56 N2b 25.59 60.31 11.15 128.07 221.06 652.08 1462.76 4558.55 4060.68 5.33 22.25 14.11 27.60 N2c 29.68 56.42 104.46 152.48 58.29 44.35 1921.61 1916.73 3673.00 6.42 6.08 11.45 27.86 N3a 36.28 195.58 60.44 22.42 261.00 35.23 1161.97 14162.25 2927.39 4.39 40.45 9.44 28.22 Nx - 29.83 19.20 - 7.32 6.08 - 466.76 376.52 - 2.76 2.28 15.00 N1 36.11 36.54 25.15 36.23 37.53 33.45 1834.10 820.64 551.32 7.84 4.25 2.65 24.25 N2 19.85 43.06 32.35 125.45 126.61 213.07 818.66 1605.68 2157.33 3.27 6.74 6.41 29.43 N3 3.62 28.14 19.15 244.98 570.70 267.49 1568.20 3788.86 1243.22 5.84 13.59 6.56 33.00 N­­ 21.10 21.19 18.95 126.49 508.33 288.23 1439.00 1501.17 1674.43 6.86 5.74 7.77 26.68 M0 ­20.98 29.86 33.77 117.54 298.81 202.49 1349.87 2026.73 1715.13 5.23 7.57 7.16 27.43 M1 41.20 158.62 28.41 38.96 169.04 7.48 1013.05 9684.81 492.24 5.18 29.81 3.29 25.51 Mx 26.06 62.22 27.73 144.46 71.39 169.99 1824.58 3421.94 3765.54 5.84 14.44 13.82 20.19 Treatment Intent Curative 24.51 42.30 32.07 106.10 249.51 187.40 1344.55 2523.72 2184.06 5.20 9.61 8.69 25.53 Palliative 22.36 8.73 - 210.43 350.29 - 2145.17 4134.33 - 7.05 12.02 - 25.32 Primary Treatment Chemoradiation 24.96 40.97 32.85 130.96 278.00 236.48 1648.40 3098.54 2966.08 6.22 11.13 11.34 29.40 Surgery 22.23 41.90 31.29 102.16 236.28 138.33 1200.21 2214.22 1402.03 4.36 8.72 6.03 22.71 RT 53.70 - - 11.82 - - 884.54 - - 6.13 - - 22.03 Chemo 16.19 0.80 - 114.40 140.95 - 974.36 456.69 - 4.28 1.54 - 38.55 Adjuvant Treatment None 25.63 32.91 33.86 122.93 253.69 239.40 1644.82 2119.68 3056.96 6.16 8.13 11.69 27.65 CRT 20.38 43.03 32.00 113.75 248.34 143.20 1202.04 2309.15 1438.63 4.25 9.05 6.18 20.54 Surgery 62.15 140.38 16.71 112.51 244.76 9.13 1844.93 10391.99 506.74 9.73 31.90 1.86 40.56 RT 30.63 23.79 - 13.60 425.88 - 1009.05 4091.68 - 4.38 16.67 - 37.33 Chemotherapy 2.45 1.53 1.04 133.02 213.35 155.38 707.88 1638.09 419.54 3.08 5.80 2.08 40.27 Margin Negative 24.52 23.77 19.02 99.02 318.56 168.88 1150.93 1367.67 895.73 4.17 5.41 4.26 31.32 n/a 24.45 55.13 41.95 122.66 161.32 171.17 1571.42 3133.41 2847.21 5.85 12.33 10.97 25.28 Positive 23.92 25.02 21.55 106.02 383.01 225.86 1203.28 2252.86 1695.84 4.96 7.32 7.01 22.68 Recurrence No 14.73 30.17 30.93 113.48 164.98 191.79 1044.07 1227.30 2267.51 4.17 6.17 9.06 27.74 Yes 28.79 48.27 18.99 167.81 500.54 210.18 1468.14 4531.35 1222.10 5.21 15.03 5.91 28.12 n/a 36.86 118.27 91.94 72.02 201.41 48.68 1990.49 8565.98 4194.39 7.48 24.14 12.66 20.16 Location of Recurrence Primary Site 21.85 38.79 26.04 252.40 437.04 98.01 1322.54 3557.62 909.84 3.95 10.47 4.48 27.72 Neck 55.07 61.77 32.67 19.19 57.32 11.62 1427.66 1354.85 775.20 5.86 7.33 3.36 26.98 Both 4.02 62.65 4.94 240.94 839.74 380.83 1603.75 7847.63 1913.25 5.97 25.04 8.38 24.51 n/a 33.52 13.02 19.85 21.38 244.35 241.36 1676.14 1959.92 1070.04 5.41 8.15 6.68 41.02 Death Yes 28.84 54.42 42.70 143.79 342.88 255.44 1650.57 3726.64 4025.86 5.97 13.53 15.00 25.79 No 21.40 33.45 26.61 95.24 205.23 152.47 1256.99 1961.08 1238.27 4.95 7.60 5.44 25.38 Death of Disease Yes 29.72 32.11 18.70 205.28 600.45 392.34 1857.69 5031.72 3361.56 6.34 16.03 7.73 32.61 No 27.96 76.73 56.69 77.90 85.32 175.58 1443.46 2421.55 4413.37 5.60 11.03 19.25 20.07 Table 4: Inflammatory index values pretreatment, at 3 months, and at 6 months Additional Declarations No competing interests reported. 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Zeitouni","email":"","orcid":"","institution":"Texas Tech University Health Sciences Center","correspondingAuthor":false,"prefix":"","firstName":"Jad","middleName":"F.","lastName":"Zeitouni","suffix":""},{"id":264995057,"identity":"dc7dafbc-d410-48c0-b0b4-4d24561732cf","order_by":2,"name":"Daniel K. Nguyen","email":"","orcid":"","institution":"Texas Tech University Health Sciences Center","correspondingAuthor":false,"prefix":"","firstName":"Daniel","middleName":"K.","lastName":"Nguyen","suffix":""},{"id":264995058,"identity":"fbec85a7-011f-434e-b94e-695807fbb1d5","order_by":3,"name":"Ismail S. Mohiuddin","email":"","orcid":"","institution":"Texas Tech University Health Sciences Center","correspondingAuthor":false,"prefix":"","firstName":"Ismail","middleName":"S.","lastName":"Mohiuddin","suffix":""},{"id":264995059,"identity":"b8c641ab-8c00-4684-a222-598a4fd17499","order_by":4,"name":"Haven Ward","email":"","orcid":"","institution":"Texas Tech University Health Sciences Center","correspondingAuthor":false,"prefix":"","firstName":"Haven","middleName":"","lastName":"Ward","suffix":""},{"id":264995060,"identity":"28357ffb-972a-4557-925c-11265b0b3e6f","order_by":5,"name":"Anu Satheeshkumar","email":"","orcid":"","institution":"Texas Tech University Health Sciences Center","correspondingAuthor":false,"prefix":"","firstName":"Anu","middleName":"","lastName":"Satheeshkumar","suffix":""},{"id":264995061,"identity":"b08281a7-e959-44a4-84b3-52fcb6804aed","order_by":6,"name":"Yusuf Dundar","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA80lEQVRIiWNgGAWjYLCCCgZmIJnAwPABSBmAhdgIaDkD1cI4I8GARC3MPMRoMbiR/kziAIN14nb25GefbX/8SdzOf/gBw4eyw3i05JgBtaQn7ux5Zjw7J8EgceeMNAPGGefwamGT/sBwOHHDjQRjZpCWDTd4GJh52/BpATsMpCX9M7MFSMt5oNf+4tWSYAbVkmPMzADSciCHgZkRjxbJM2+MLQ4YpBtvOPOmmLEnzdh4w400g4M959JxauE7nv7wxoEKa9kNx9M3M/ywkZPdcP7wwwc/yqxxalE4AHYemugBnOqBQL4Bn+woGAWjYBSMAhAAAArDXkh/SN2QAAAAAElFTkSuQmCC","orcid":"","institution":"Texas Tech University Health Sciences Center","correspondingAuthor":true,"prefix":"","firstName":"Yusuf","middleName":"","lastName":"Dundar","suffix":""}],"badges":[],"createdAt":"2024-01-02 19:29:17","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3830223/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3830223/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":49237734,"identity":"73c33c88-dd2b-4b98-be14-53e9f31dd740","added_by":"auto","created_at":"2024-01-05 18:02:28","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":141454,"visible":true,"origin":"","legend":"\u003cp\u003eKaplan Meier’s showing overall survival outcomes related with 3 months changes of related inflammatory markers. Survival favors decrease in inflammatory markers.\u003c/p\u003e","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-3830223/v1/f31361d8a7f0474ca26f7409.png"},{"id":49237733,"identity":"34653bb0-65d9-436f-a14a-b1001b96f04e","added_by":"auto","created_at":"2024-01-05 18:02:28","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":308327,"visible":true,"origin":"","legend":"\u003cp\u003eKaplan Meier’s showing Overall Survival Outcomes related with 6 months Inflammatory marker changes.\u003c/p\u003e","description":"","filename":"floatimage2.png","url":"https://assets-eu.researchsquare.com/files/rs-3830223/v1/4476fdbe6dca205b93091eb8.png"},{"id":49237735,"identity":"a0441bf4-3921-4df8-aec9-50bdc059747c","added_by":"auto","created_at":"2024-01-05 18:02:28","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":703051,"visible":true,"origin":"","legend":"\u003cp\u003eKaplan Meier’s showing Disease Free Survival related with 3 months changes of related inflammatory markers.\u003c/p\u003e","description":"","filename":"floatimage3.png","url":"https://assets-eu.researchsquare.com/files/rs-3830223/v1/f0a52cfe2909573286e67efd.png"},{"id":49237736,"identity":"6f2666a0-18ed-40b4-8fd1-064da2633f54","added_by":"auto","created_at":"2024-01-05 18:02:28","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":771272,"visible":true,"origin":"","legend":"\u003cp\u003eKaplan Meier’s showing disease free survival related with 6 months changes of related inflammatory markers.\u003c/p\u003e","description":"","filename":"floatimage4.png","url":"https://assets-eu.researchsquare.com/files/rs-3830223/v1/cef50a284a6c3b54cd518d26.png"},{"id":49288385,"identity":"1143e0ca-eee6-4fb0-85c8-c6deb2bfa6c7","added_by":"auto","created_at":"2024-01-08 03:37:22","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1379112,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3830223/v1/4afe5746-8f69-4b37-8086-4924f7972b96.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"The Effectiveness of Inflammatory Indexes in Assessing Oropharyngeal Cancer Prognosis","fulltext":[{"header":"Introduction","content":"\u003cp\u003eInflammation has long been a key tenet in the diagnosis and management of malignancies, likely contributing to cancer incidence, staging, and progression.\u003csup\u003e\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e,\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e\u003c/sup\u003e Systemic inflammation, in particular, is often elevated prior to and during cancer development.\u003csup\u003e\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e\u003c/sup\u003e Systemic inflammation in the context of cancer diagnosis and monitoring is measured by various inflammatory indexes such as Systemic inflammatory response index (SIRI), plasma-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and neutrophil-to-lymphocyte ratio (NLR). There is robust literature showing the elevation of various inflammatory indexes in different cancers.\u003c/p\u003e \u003cp\u003eThere have been several studies in the literature examining the relationship between the aforementioned inflammatory indexes and various types of different. The neutrophil to lymphocyte ratio (NLR) has been shown in several studies to be a biomarker associated with decreased survival and prognosis in several solid tumor cancers.\u003csup\u003e\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e\u003c/sup\u003e Higher NLR has been associated with increased tumor growth and prognosis in various cancers of the gastrointestinal system.\u003csup\u003e\u003cspan additionalcitationids=\"CR5\" citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e\u003c/sup\u003e Elevated NLR has also been shown to be an indicator of poor prognosis in squamous cell carcinoma of the head and neck.\u003csup\u003e\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e\u003c/sup\u003e Elevated platelet-to-lymphocyte ratios (PLR) have also been correlated with poor prognosis in a host of different cancers, including melanoma, rectal, and hepatocellular carcinoma.\u003csup\u003e\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e,\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e,\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e \u003cp\u003eSIRI is an inflammatory index that is based on the ratio of neutrophil count, monocyte count, and lymphocyte count.\u003csup\u003e\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e\u003c/sup\u003e Several studies have shown that SIRI is an important inflammatory index in the progression of many tumors.\u003csup\u003e\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e\u003c/sup\u003e It was shown to be an independent prognosis indicator in gallbladder cancer.\u003csup\u003e\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e\u003c/sup\u003e It was also been shown to be a prognostic biomarker in squamous cell carcinoma of the head and neck.\u003csup\u003e\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e \u003cp\u003eElevated systemic Immune inflammation index (SII) has been an indicator of poor prognosis in patients treated with immune checkpoint inhibitors immunotherapy.\u003csup\u003e\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e\u003c/sup\u003e Elevated SII has been associated with poor prognosis in several malignancies, including bladder and non-small cell lung cancer.\u003csup\u003e\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e,\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e\u003c/sup\u003e Oropharyngeal cancer is one of the most common malignancies worldwide and the 7th leading cause of cancer deaths worldwide.\u003csup\u003e\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u003c/sup\u003e OPC is associated with tobacco use, alcohol consumption, and human papillomavirus (HPV).\u003csup\u003e\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u003c/sup\u003e Additionally, OPC, particularly HPV-associated OPC, has been on the rise in the united states.\u003csup\u003e\u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e\u003c/sup\u003e The literature regarding the association of the various inflammatory indexes and prognosis of various malignancies is quite robust; however, oropharyngeal cancer (OPC) has been sparsely explored in this area. Furthermore, exploring and comparing which inflammatory indexes are the best determinates of outcome and prognosis in OPC is an emerging area in the literature that we set out to explore.\u003c/p\u003e \u003cp\u003eWe set out to determine the relationship between the SIRI, PLR, SII, and NLR inflammatory indexes and the prognosis and outcomes of OPC. Additionally, we wanted to determine which indexes are the most significant prognosis indicators of OPC. We conducted a single institution retrospective chart review of 172 patients with OPC and evaluated their inflammatory index levels.\u003c/p\u003e"},{"header":"Material/methods","content":"\u003cp\u003eWith approval from the Texas Tech University Health Sciences Center Internal Review Board, a retrospective chart review identified 172 patients who underwent treatment for oropharyngeal cancer\u0026nbsp;from May 9 2013 to May 9 2023. Patients who did not have any available pre-treatment and post treatment blood work to analyze and those who did not have greater than 3 months of follow-up post-treatment were excluded.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eBasic demographic information, such as gender, age, BMI, and ethnicity, as well as identified risk factors, such as smoking and alcohol use, were gathered (Table 1). Sites of primary cancer were obtained through chart review, which was classified as tonsil, base of tongue, soft palate, posterior, and overlapping. Furthermore, HPV infection status (positive, negative, n/a) and differentiation of the tumor (well,\u0026nbsp;moderate, poor, undifferentiated) were noted for each patient. Tumor staging was recorded according to the 7th and 8th editions of oropharyngeal cancer staging according to the American Cancer Society. Treatment intent was tabulated as either curative or palliative therapy, with the treatment modalities classified as surgery, radiation, chemotherapy, or concurrent chemotherapy and radiation. Patients who received adjuvant treatments were also noted. Post-treatment margin status was noted as either negative, positive, or n/a, and treatment outcomes were classified based on recurrence and death secondary to disease. If recurrence was observed, the location was noted as either the primary site, neck, both, or not specified. The relationships between treatment outcome and pre and posttreatment levels of inflammatory indexes such as systemic inflammatory response index (SIRI), plasma-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and neutrophil-to-lymphocyte ratio (NLR) were evaluated.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eStatistical analysis was performed using SPSS (Version 23, IBM, USA). Multiple testing was used based on the large number of variables. Descriptive statistics were performed by independent t-tests and the Mann-Whiney U-test for mean comparisons of variables with two groupings. For variables with groupings of three or more a one-way ANOVA (analysis of variance) test was utilized. Chi-squared and Fisher\u0026rsquo;s exact tests were used to analyze categorical variables. Univariate survival estimates were generated by the Kaplan-Meier method and compared with the log-rank test. Multivariate survival analysis was performed using the Cox proportional hazard regression model, utilizing all variables approaching significance (p 0.2) to control for confounding covariates. All tests were two-tailed, and results were considered significant for p 0.05.\u0026nbsp;\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eInitial screening revealed with 263 patients and 91patient were excluded from the study because of either lack of blood work or appropriate follow up. \u0026nbsp;As shown in Table 1, the demographics for the final cohort included 172 patients, 79.1% male and 20.9% female. Most patients identified as Caucasian (86%) and 2.9% identified as black. 46.5% of the patients had a smoking history of more than 10 pack years, 14% that of less than 10 pack years and 39.5% had no previous smoking history. In regard to alcohol history, 48.3% denied any alcohol use while 30.8% drank socially and 20.9% drank heavily. The most common site for oropharyngeal cancer was BOT, at 44.2%, followed by the tonsil (27.9%), overlapping (16.3%), posterior (6.4%), and soft palate (5.2%). HPV status was divided into positive (37.7%), negative (30.3%), and N/A (30.3%) and differentiation status into well (6.4%), moderate (36.0%), poor (27.3%), and undifferentiated (30.2%).\u003c/p\u003e\n\u003cp\u003eTumor staging was divided according to the 7th and 8th editions\u0026nbsp;according to American cancer society as shown in Table 2 and showed relatively even distribution of patients. Table 3 describes the treatment intent and outcomes, which showed that for 94.2% of patients, the goal of treatment was curative, with surgery (57.6%) employed as the most common primary treatment, followed by chemotherapy and radiation combined (39.0%) . Chemotherapy and radiation combined (50%) was the most common neoadjuvant treatment. Following treatment, 23.8% of the total patients had recurrence of disease with local recurrence at the neck being the most common (35%) followed by the primary site (32.5%), both (25%), and unspecified (7.5%). In total, 59 patients (34.3%) died and of those, 26 patients (44.1%) died due to disease.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTable 4 shows the pre-treatment, 3 month, and 6 month mean values of the inflammatory markers SIRI, PLR, SII, NLR, and PNI values divided according to sex, ethnicity, smoking and alcohol history, location of tumor, HPV status, tumor differentiation, AJCC staging (7th and 8th edition), treatment intent, primary treatment, adjuvant treatment, margin status, recurrence, location of recurrence, and death. Of these values, we found that pretreatment SIRI and Albumin levels were positively predictive in determining locoregional recurrence (p=.031 and p=.039). NLR, SII, and SIRI levels taken at three months post-treatment were also found to be positively predictive of locoregional recurrence (p=.005, p\u0026lt;.0005, and p=.007), as well as SIRI taken at six months post-treatment (p=.008). Lastly, SII at six months post-treatment was positively predictive of survival (p=.027). Figures 1, 2, 3, and 4 summarize survival outcomes on Kaplan-Meier Curves. Decreased inflammatory markers are associated with improved survival outcomes on Kaplan-Meier Curves. However, only SII at six months post-treatment value was statistically significant on the Cox proportional hazard test (p=.027).\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThis retrospective project aimed to evaluate the role the inflammatory indexes of SIRI, PLR, SII, NLR, and PNI have on Head and Neck cancer prognosis. These inflammatory indexes have been well described in the literature in the context of cancer incidence and prognosis.\u003csup\u003e\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e, \u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e \u003cp\u003eThere has not been a definitive consensus in the literature on the role and prognosis value of inflammatory indexes in head and neck cancer.\u003csup\u003e\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e\u003c/sup\u003e Other effective prognosis indicators in Head and neck cancer include TNM (Tumor, Node, Metastasis) staging and HPV-positive status of head and neck cancer.\u003csup\u003e\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e\u003c/sup\u003e\u003c/p\u003e \u003cp\u003eSIRI is calculated by multiplying neutrophils by the ratio of monocytes/lymphocytes.\u003csup\u003e12\u003c/sup\u003e SIRI has been shown to be an independent predictor disease specific survival in head and neck squamous cell carcinoma.\u003csup\u003e\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e\u003c/sup\u003e SIRI was also shown to be a predictor in local, regional, and distant recurrence-free survival.\u003csup\u003e\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e\u003c/sup\u003e It is seen as an effective prognosis indicator in head and neck cancers.\u003csup\u003e\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e\u003c/sup\u003e On that note, our findings on SIRI were particularly robust regarding locoregional recurrence. We found that pretreatment SIRI was positively predictive in determining locoregional recurrence (p\u0026thinsp;=\u0026thinsp;.031). SIRI taken at three months post-treatment was also found to be positively predictive of locoregional recurrence ( p\u0026thinsp;=\u0026thinsp;.007). Finally, SIRI taken at six months post-treatment was also found to be positively predictive of locoregional recurrence (p\u0026thinsp;=\u0026thinsp;.008). This is consistent with the previous literature stating that pretreatment SIRI levels are a predictor in local and regional recurrence-fee survival.\u003csup\u003e\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e\u003c/sup\u003e This study builds on the existing literature by showing SIRI taken at 3-month and 6-month intervals after treatment was significantly predictive with locoregional recurrence.\u003c/p\u003e \u003cp\u003eSII is calculated by multiplying platelet count by neutrophil count/lymphocyte count.\u003csup\u003e\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e\u003c/sup\u003e SII has been used as a prognosis predictor in several cancers, including cervical, colorectal, bladder, lung, and liver cancer.\u003csup\u003e\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e\u003c/sup\u003e A high SII in head and neck cancer patients prior to receiving treatment has been shown to be predictive of decreased overall survival and more advanced tumor status.\u003csup\u003e\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e\u003c/sup\u003e SII levels taken at three months post-treatment was found to be highly predictive of locoregional recurrence ( p\u0026thinsp;\u0026gt;\u0026thinsp;.0005). Additionally, SII at six months post-treatment was found to be positively predictive of survival (p\u0026thinsp;=\u0026thinsp;.027). Our results did not show significance the prognosis effectiveness in pretreatment levels of SII. However, we were able to show significance using post-treatment SII levels in both recurrence (taken at 3 months post treatment) and survival (taken at 6 months post treatment).\u003c/p\u003e \u003cp\u003eNLR, which is the neutrophil to lymphocyte ratio, and PLR, which is the platelet to lymphocyte ratio, are inflammatory markers that have been shown to have prognostic value in several cancers.\u003csup\u003e\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e\u003c/sup\u003e Higher pretreatment PLR and NLR values have been shown to be associated with poor survivability in pancreatic, gastrointestinal, bladder, and ovarian cancers.\u003csup\u003e\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e\u003c/sup\u003e Elevated pretreatment PLR and NLR have been associated with poor survivability in head and neck cancer patients, regardless of treatment modality (surgery or chemotherapy).\u003csup\u003e\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e\u003c/sup\u003e NLR llevels taken at three months post-treatment were also found to be positively predictive of locoregional recurrence (p\u0026thinsp;=\u0026thinsp;.005). Again, we did not find significance with the pretreatment levels NLR, which the majority of the existing literature focuses on. We did, however, find significance, in the 3 month post-treatment NLR level. It should be noted that we did not find significance in both pretreatment and posttreatment levels of NLR.\u003c/p\u003e \u003cp\u003eFinally, PNI, which is the Prognostic Nutritional Index, is calculated by the serum albumin concentration and the total lymphocyte count in the peripheral blood.\u003csup\u003e\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e\u003c/sup\u003e Low PNI has been shown to be associated with worse overall survival in patients with esophageal cancer.\u003csup\u003e\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e\u003c/sup\u003e Low PNI has been shown to be significantly associated with poor overall survival in patients with head and neck cancer, but it was not a significant indicator of disease-specific survival.\u003csup\u003e\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e\u003c/sup\u003e Pretreatment albumin levels was found to be positively predictive in determining locoregional recurrence ( p\u0026thinsp;=\u0026thinsp;0.039). This is in line with the previous literature.\u003c/p\u003e \u003cp\u003e The limitations of this study are that it is a single-center retrospective chart review and our cohort size of 172 patients. Our study was underpowered to find significance for pretreatment levels of several of the inflammatory indexes in locoregional recurrence and overall survival. Aside from these limitations, this study signifies a notable addition to the literature that signifies the value of post-treatment levels of inflammatory indexes as a prognosis and recurrence indicator in head and neck cancer.\u003c/p\u003e \u003cp\u003eThis study built on the existing literature showing the value of inflammatory indexes as a prognosis indicator in head and neck cancer. Much of the literature has focused on utilizing pretreatment levels of inflammatory indexes; this study uniquely examined both pretreatment and posttreatment (measured at three and six months intervals). Additionally, this study also demonstrates the value of using inflammatory indexes to evaluate locoregional tumor recurrence in head and neck cancer. SIRI and Albumin pretreatment levels were the only indexes shown to have predictive value in locoregional recurrence. SIRI taken at both three and six-month post-treatment was also found to be predictive of locoregional recurrence. NLR and SII at three months posttreatment were found to be predictive of locoregional recurrence. SII was the only inflammatory index to show a significant correlation with post-treatment levels and overall survival. Overall, we have uniquely highlighted the value post-treatment inflammatory indexes may have as prognosis and locoregional indicators for head and neck cancer.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eThis study suggested that post-treatment levels of several inflammatory indexes, particularly SIRI, NLR, and SII, may be useful in determining long-term outlook and recurrence of head and neck cancer following treatment. This builds on the existing literature that primarily focuses on pretreatment levels of inflammatory indexes and their prognosis value for overall survival. Additionally, it highlights the need for future studies to further evaluate the role posttreatment inflammatory index levels have on future recurrence and overall prognosis of head and neck cancer. Also, inflammatory markers of those patient received immunotherapy regimens may help to understand pathophysiology of disease would be very interesting and helpful.\u003c/p\u003e"},{"header":"Declarations","content":"\u003ch2\u003eFunding:\u003c/h2\u003e \u003cp\u003eNone\u003c/p\u003e \u003cp\u003e \u003cstrong\u003eConflicts of interest:\u003c/strong\u003e \u003cp\u003eNone\u003c/p\u003e \u003c/p\u003e\u003ch2\u003eAuthor Contribution\u003c/h2\u003e\u003cp\u003eW.J.: Manuscript draft and editsJ.Z.: Manuscript draft and editsD.N.: Data CollectionI.M.: Data CollectionH.W. Data CollectionA.S.: Data CollectionY.D.: Statistical Analysis, Manuscript edits\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eN\u0026oslash;st TH, Alcala K, Urbarova I, et al. Systemic inflammation markers and cancer incidence in the UK Biobank. \u003cem\u003eEur J Epidemiol\u003c/em\u003e. Aug 2021;36(8):841-848. doi:10.1007/s10654-021-00752-6\u003c/li\u003e\n\u003cli\u003eDiakos CI, Charles KA, McMillan DC, Clarke SJ. Cancer-related inflammation and treatment effectiveness. \u003cem\u003eLancet Oncol\u003c/em\u003e. Oct 2014;15(11):e493-503. doi:10.1016/s1470-2045(14)70263-3\u003c/li\u003e\n\u003cli\u003eTempleton AJ, McNamara MG, \u0026Scaron;eruga B, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. \u003cem\u003eJ Natl Cancer Inst\u003c/em\u003e. Jun 2014;106(6):dju124. doi:10.1093/jnci/dju124\u003c/li\u003e\n\u003cli\u003eLin N, Li J, Yao X, et al. Prognostic value of neutrophil-to-lymphocyte ratio in colorectal cancer liver metastasis: A meta-analysis of results from multivariate analysis. \u003cem\u003eInt J Surg\u003c/em\u003e. Nov 2022;107:106959. doi:10.1016/j.ijsu.2022.106959\u003c/li\u003e\n\u003cli\u003eMiyamoto R, Inagawa S, Sano N, Tadano S, Adachi S, Yamamoto M. The neutrophil-to-lymphocyte ratio (NLR) predicts short-term and long-term outcomes in gastric cancer patients. \u003cem\u003eEur J Surg Oncol\u003c/em\u003e. May 2018;44(5):607-612. doi:10.1016/j.ejso.2018.02.003\u003c/li\u003e\n\u003cli\u003eSchobert IT, Savic LJ, Chapiro J, et al. Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictors of tumor response in hepatocellular carcinoma after DEB-TACE. \u003cem\u003eEur Radiol\u003c/em\u003e. Oct 2020;30(10):5663-5673. doi:10.1007/s00330-020-06931-5\u003c/li\u003e\n\u003cli\u003eFerrandino RM, Roof S, Garneau J, et al. Neutrophil-to-lymphocyte ratio as a prognostic indicator for overall and cancer-specific survival in squamous cell carcinoma of the head and neck. \u003cem\u003eHead Neck\u003c/em\u003e. Oct 2020;42(10):2830-2840. doi:10.1002/hed.26329\u003c/li\u003e\n\u003cli\u003eLi B, Zhou P, Liu Y, et al. 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Systemic inflammation response index (SIRI) as a novel biomarker in patients with rheumatoid arthritis: a multi-center retrospective study. \u003cem\u003eClin Rheumatol\u003c/em\u003e. 2022;41(7):1989-2000. doi:10.1007/s10067-022-06122-1\u003c/li\u003e\n\u003cli\u003eValero C, Pardo L, Sansa A, et al. Prognostic capacity of Systemic Inflammation Response Index (SIRI) in patients with head and neck squamous cell carcinoma. \u003cem\u003eHead Neck\u003c/em\u003e. Feb 2020;42(2):336-343. doi:10.1002/hed.26010\u003c/li\u003e\n\u003cli\u003eTian BW, Yang YF, Yang CC, et al. Systemic immune-inflammation index predicts prognosis of cancer immunotherapy: systemic review and meta-analysis. \u003cem\u003eImmunotherapy\u003c/em\u003e. Dec 2022;14(18):1481-1496. doi:10.2217/imt-2022-0133\u003c/li\u003e\n\u003cli\u003eLi J, Cao D, Huang Y, et al. The Prognostic and Clinicopathological Significance of Systemic Immune-Inflammation Index in Bladder Cancer. \u003cem\u003eFront Immunol\u003c/em\u003e. 2022;13:865643. doi:10.3389/fimmu.2022.865643\u003c/li\u003e\n\u003cli\u003eLiu J, Li S, Zhang S, et al. Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio can predict clinical outcomes in patients with metastatic non-small-cell lung cancer treated with nivolumab. \u003cem\u003eJ Clin Lab Anal\u003c/em\u003e. Oct 2019;33(8):e22964. doi:10.1002/jcla.22964\u003c/li\u003e\n\u003cli\u003eBosetti C, Carioli G, Santucci C, et al. Global trends in oral and pharyngeal cancer incidence and mortality. \u003cem\u003eInt J Cancer\u003c/em\u003e. Aug 15 2020;147(4):1040-1049. doi:10.1002/ijc.32871\u003c/li\u003e\n\u003cli\u003eYamahara K, Mizukoshi A, Lee K, Ikegami S. Pretherapeutic nutritional/inflammatory factors as predictors for survival of both early and advanced staged head and neck cancer patients. \u003cem\u003eAuris Nasus Larynx\u003c/em\u003e. 2021;48(4):731-737. doi:10.1016/j.anl.2020.11.007\u003c/li\u003e\n\u003cli\u003eBossi P. Prognostic Nutritional Index: an easy nutritional screening for patients with head and neck cancer?. \u003cem\u003eESMO Open\u003c/em\u003e. 2018;3(6):e000449. Published 2018 Oct 24. doi:10.1136/esmoopen-2018-000449\u003c/li\u003e\n\u003cli\u003eWang YT, Kuo LT, Weng HH, et al. Systemic Immun e-Inflammation Index as a Predictor for Head and Neck Cancer Prognosis: A Meta-Analysis. \u003cem\u003eFront Oncol\u003c/em\u003e. 2022;12:899518. Published 2022 Jun 24. doi:10.3389/fonc.2022.899518\u003c/li\u003e\n\u003cli\u003eAbelardo E, Davies G, Kamhieh Y, Prabhu V. Are Inflammatory Markers Significant Prognostic Factors for Head and Neck Cancer Patients?. \u003cem\u003eORL J Otorhinolaryngol Relat Spec\u003c/em\u003e. 2020;82(5):235-244. doi:10.1159/000507027\u003c/li\u003e\n\u003cli\u003eOkadome K, Baba Y, Yagi T, et al. Prognostic Nutritional Index, Tumor-infiltrating Lymphocytes, and Prognosis in Patients with Esophageal Cancer. \u003cem\u003eAnn Surg\u003c/em\u003e. 2020;271(4):693-700. doi:10.1097/SLA.0000000000002985\u003c/li\u003e\n\u003cli\u003eAtasever Akkas E, Erdis E, Yucel B. Prognostic value of the systemic immune-inflammation index, systemic inflammation response index, and prognostic nutritional index in head and neck cancer [published correction appears in Eur Arch Otorhinolaryngol. 2023 Jun 8;:]. \u003cem\u003eEur Arch Otorhinolaryngol\u003c/em\u003e. 2023;280(8):3821-3830. doi:10.1007/s00405-023-07954-6\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eNumber\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003ePercent\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eGender\u003c/p\u003e\n \u003cp\u003eMale\u003c/p\u003e\n \u003cp\u003eFemale\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e136\u003c/p\u003e\n \u003cp\u003e36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e79.1%\u003c/p\u003e\n \u003cp\u003e20.9%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eEthnicity\u003c/p\u003e\n \u003cp\u003eCaucasian\u003c/p\u003e\n \u003cp\u003eBlack\u003c/p\u003e\n \u003cp\u003eHispanic or other\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e148\u003c/p\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003cp\u003e19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e86.0%\u003c/p\u003e\n \u003cp\u003e2.9%\u003c/p\u003e\n \u003cp\u003e11.0%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eSmoking\u003c/p\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003cp\u003eLess than 10 packs\u003c/p\u003e\n \u003cp\u003eMore than 10 packs\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e68\u003c/p\u003e\n \u003cp\u003e24\u003c/p\u003e\n \u003cp\u003e80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e39.5%\u003c/p\u003e\n \u003cp\u003e14.0%\u003c/p\u003e\n \u003cp\u003e46.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eAlcohol\u003c/p\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003cp\u003eSocially\u003c/p\u003e\n \u003cp\u003eHeavily\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e83\u003c/p\u003e\n \u003cp\u003e53\u003c/p\u003e\n \u003cp\u003e36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e48.3%\u003c/p\u003e\n \u003cp\u003e30.8%\u003c/p\u003e\n \u003cp\u003e20.9%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eSite\u003c/p\u003e\n \u003cp\u003eTonsil\u003c/p\u003e\n \u003cp\u003eBOT\u003c/p\u003e\n \u003cp\u003eSoft Palate\u003c/p\u003e\n \u003cp\u003ePosterior\u003c/p\u003e\n \u003cp\u003eOverlapping\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e48\u003c/p\u003e\n \u003cp\u003e76\u003c/p\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003cp\u003e28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e27.9%\u003c/p\u003e\n \u003cp\u003e44.2%\u003c/p\u003e\n \u003cp\u003e5.2%\u003c/p\u003e\n \u003cp\u003e6.4%\u003c/p\u003e\n \u003cp\u003e16.3%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eHPV\u003c/p\u003e\n \u003cp\u003ePositive\u003c/p\u003e\n \u003cp\u003eNegative\u003c/p\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e66\u003c/p\u003e\n \u003cp\u003e53\u003c/p\u003e\n \u003cp\u003e53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e37.7%\u003c/p\u003e\n \u003cp\u003e30.3%\u003c/p\u003e\n \u003cp\u003e30.3%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eDifferentiation\u003c/p\u003e\n \u003cp\u003eWell\u003c/p\u003e\n \u003cp\u003eModerate\u003c/p\u003e\n \u003cp\u003ePoor\u003c/p\u003e\n \u003cp\u003eUndifferentiated\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003cp\u003e62\u003c/p\u003e\n \u003cp\u003e47\u003c/p\u003e\n \u003cp\u003e52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e6.4%\u003c/p\u003e\n \u003cp\u003e36.0%\u003c/p\u003e\n \u003cp\u003e27.3%\u003c/p\u003e\n \u003cp\u003e30.2%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eTable 1: Patient Demographics\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eNumber\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003ePercentage\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eT staging (7\u003csup\u003eth\u003c/sup\u003e edition)\u003c/p\u003e\n \u003cp\u003eT1\u003c/p\u003e\n \u003cp\u003eT2\u003c/p\u003e\n \u003cp\u003eT3\u003c/p\u003e\n \u003cp\u003eT4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e24\u003c/p\u003e\n \u003cp\u003e44\u003c/p\u003e\n \u003cp\u003e62\u003c/p\u003e\n \u003cp\u003e42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e14.0%\u003c/p\u003e\n \u003cp\u003e25.6%\u003c/p\u003e\n \u003cp\u003e36.0%\u003c/p\u003e\n \u003cp\u003e24.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eN staging (7\u003csup\u003eth\u003c/sup\u003e edition)\u003c/p\u003e\n \u003cp\u003eN0\u003c/p\u003e\n \u003cp\u003eN1\u003c/p\u003e\n \u003cp\u003eN2a\u003c/p\u003e\n \u003cp\u003eN2b\u003c/p\u003e\n \u003cp\u003eN2c\u003c/p\u003e\n \u003cp\u003eN3a\u003c/p\u003e\n \u003cp\u003eN3b\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e31\u003c/p\u003e\n \u003cp\u003e36\u003c/p\u003e\n \u003cp\u003e23\u003c/p\u003e\n \u003cp\u003e39\u003c/p\u003e\n \u003cp\u003e16\u003c/p\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e18.0%\u003c/p\u003e\n \u003cp\u003e20.9%\u003c/p\u003e\n \u003cp\u003e13.4%\u003c/p\u003e\n \u003cp\u003e22.7%\u003c/p\u003e\n \u003cp\u003e9.3%\u003c/p\u003e\n \u003cp\u003e11.6%\u003c/p\u003e\n \u003cp\u003e4.1%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eM staging (7\u003csup\u003eth\u003c/sup\u003e edition)\u003c/p\u003e\n \u003cp\u003eM0\u003c/p\u003e\n \u003cp\u003eM1\u003c/p\u003e\n \u003cp\u003eMx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e119\u003c/p\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003cp\u003e42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e69.2%\u003c/p\u003e\n \u003cp\u003e6.4%\u003c/p\u003e\n \u003cp\u003e24.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eT staging (8\u003csup\u003eth\u003c/sup\u003e edition)\u003c/p\u003e\n \u003cp\u003eT1\u003c/p\u003e\n \u003cp\u003eT2\u003c/p\u003e\n \u003cp\u003eT3\u003c/p\u003e\n \u003cp\u003eT4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e24\u003c/p\u003e\n \u003cp\u003e44\u003c/p\u003e\n \u003cp\u003e62\u003c/p\u003e\n \u003cp\u003e42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e14.0%\u003c/p\u003e\n \u003cp\u003e25.6%\u003c/p\u003e\n \u003cp\u003e36.0%\u003c/p\u003e\n \u003cp\u003e24.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eN staging (8\u003csup\u003eth\u003c/sup\u003e edition)\u003c/p\u003e\n \u003cp\u003eN0\u003c/p\u003e\n \u003cp\u003eN1 (P16 -)\u003c/p\u003e\n \u003cp\u003eN2a (P16 -)\u003c/p\u003e\n \u003cp\u003eN2b (P16 -)\u003c/p\u003e\n \u003cp\u003eN2c (P16 -)\u003c/p\u003e\n \u003cp\u003eN3a (P16 -)\u003c/p\u003e\n \u003cp\u003eN3b (P16 -)\u003c/p\u003e\n \u003cp\u003eN1 (P16 +)\u003c/p\u003e\n \u003cp\u003eN2 (P16 +)\u003c/p\u003e\n \u003cp\u003eN3 (P16 +)\u003c/p\u003e\n \u003cp\u003eNx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e31\u003c/p\u003e\n \u003cp\u003e24\u003c/p\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003cp\u003e24\u003c/p\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003cp\u003e20\u003c/p\u003e\n \u003cp\u003e27\u003c/p\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e18.0%\u003c/p\u003e\n \u003cp\u003e14.0%\u003c/p\u003e\n \u003cp\u003e5.8%\u003c/p\u003e\n \u003cp\u003e14.0%\u003c/p\u003e\n \u003cp\u003e5.8%\u003c/p\u003e\n \u003cp\u003e6.4%\u003c/p\u003e\n \u003cp\u003e1.7%\u003c/p\u003e\n \u003cp\u003e11.6%\u003c/p\u003e\n \u003cp\u003e15.7%\u003c/p\u003e\n \u003cp\u003e5.2%\u003c/p\u003e\n \u003cp\u003e1.7%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eM staging (8\u003csup\u003eth\u003c/sup\u003e edition)\u003c/p\u003e\n \u003cp\u003eM0\u003c/p\u003e\n \u003cp\u003eM1\u003c/p\u003e\n \u003cp\u003eMx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e119\u003c/p\u003e\n \u003cp\u003e11\u003c/p\u003e\n \u003cp\u003e42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e69.2%\u003c/p\u003e\n \u003cp\u003e6.4%\u003c/p\u003e\n \u003cp\u003e24.4%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eTable 2: Tumor Staging\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eNumber\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003ePercentage\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eTreatment Intent\u003c/p\u003e\n \u003cp\u003eCurative\u003c/p\u003e\n \u003cp\u003ePalliative\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e162\u003c/p\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e94.2%\u003c/p\u003e\n \u003cp\u003e5.8%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003ePrimary Treatment\u003c/p\u003e\n \u003cp\u003eChemo/Radiation\u003c/p\u003e\n \u003cp\u003eSurgery\u003c/p\u003e\n \u003cp\u003eRadiation\u003c/p\u003e\n \u003cp\u003eChemotherapy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e67\u003c/p\u003e\n \u003cp\u003e99\u003c/p\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e39.0%\u003c/p\u003e\n \u003cp\u003e57.6%\u003c/p\u003e\n \u003cp\u003e2.3%\u003c/p\u003e\n \u003cp\u003e1.2%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eAdjuvant Treatment\u003c/p\u003e\n \u003cp\u003eNone\u003c/p\u003e\n \u003cp\u003eChemo/Radiation\u003c/p\u003e\n \u003cp\u003eSurgery\u003c/p\u003e\n \u003cp\u003eRadiation\u003c/p\u003e\n \u003cp\u003eChemotherapy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e66\u003c/p\u003e\n \u003cp\u003e86\u003c/p\u003e\n \u003cp\u003e9\u003c/p\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e38.4%\u003c/p\u003e\n \u003cp\u003e50.0%\u003c/p\u003e\n \u003cp\u003e5.2%\u003c/p\u003e\n \u003cp\u003e4.1%\u003c/p\u003e\n \u003cp\u003e2.3%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eMargin Status\u003c/p\u003e\n \u003cp\u003eNegative\u003c/p\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003cp\u003ePositive\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e32\u003c/p\u003e\n \u003cp\u003e79\u003c/p\u003e\n \u003cp\u003e61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e18.6%\u003c/p\u003e\n \u003cp\u003e45.9%\u003c/p\u003e\n \u003cp\u003e35.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eRecurrence\u003c/p\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003cp\u003eN/A\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e78\u003c/p\u003e\n \u003cp\u003e41\u003c/p\u003e\n \u003cp\u003e53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e45.3%\u003c/p\u003e\n \u003cp\u003e23.8%\u003c/p\u003e\n \u003cp\u003e30.8%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eLocal Recurrence\u003c/p\u003e\n \u003cp\u003ePrimary Site\u003c/p\u003e\n \u003cp\u003eNeck\u003c/p\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003cp\u003eNot specified\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e13\u003c/p\u003e\n \u003cp\u003e14\u003c/p\u003e\n \u003cp\u003e10\u003c/p\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e32.5%\u003c/p\u003e\n \u003cp\u003e35.0%\u003c/p\u003e\n \u003cp\u003e25.0%\u003c/p\u003e\n \u003cp\u003e7.5%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eDeath\u003c/p\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e59\u003c/p\u003e\n \u003cp\u003e113\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e34.3%\u003c/p\u003e\n \u003cp\u003e65.7%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003eDeath Due to Disease\u003c/p\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e26\u003c/p\u003e\n \u003cp\u003e33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"33.333333333333336%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003cp\u003e44.1%\u003c/p\u003e\n \u003cp\u003e55.9%\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eTable 3: Treatments and oncologic outcomes\u003c/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003c/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\" width=\"634\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd width=\"18.64139020537125%\" colspan=\"2\" rowspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"18.167456556082147%\" colspan=\"3\" valign=\"top\"\u003e\n \u003cp\u003eSIRI\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"18.64139020537125%\" colspan=\"3\" valign=\"top\"\u003e\n \u003cp\u003ePLR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"19.43127962085308%\" colspan=\"3\" valign=\"top\"\u003e\n \u003cp\u003eSII\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"18.167456556082147%\" colspan=\"3\" valign=\"top\"\u003e\n \u003cp\u003eNLR\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.9510268562401265%\" valign=\"top\"\u003e\n \u003cp\u003ePNI\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.51063829787234%\" valign=\"top\"\u003e\n \u003cp\u003ePre- Treatment\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.963249516441006%\" valign=\"top\"\u003e\n \u003cp\u003e3 months\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.963249516441006%\" valign=\"top\"\u003e\n \u003cp\u003e6 months\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.51063829787234%\" valign=\"top\"\u003e\n \u003cp\u003ePre- Treatment\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.350096711798839%\" valign=\"top\"\u003e\n \u003cp\u003e3 months\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.963249516441006%\" valign=\"top\"\u003e\n \u003cp\u003e6 months\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.51063829787234%\" valign=\"top\"\u003e\n \u003cp\u003ePre- Treatment\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.93036750483559%\" valign=\"top\"\u003e\n \u003cp\u003e3 months\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.350096711798839%\" valign=\"top\"\u003e\n \u003cp\u003e6 months\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.51063829787234%\" valign=\"top\"\u003e\n \u003cp\u003ePre- Treatment\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.963249516441006%\" valign=\"top\"\u003e\n \u003cp\u003e3 months\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.963249516441006%\" valign=\"top\"\u003e\n \u003cp\u003e6 months\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"8.51063829787234%\" valign=\"top\"\u003e\n \u003cp\u003ePre-Treatment\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003eSex\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eMale (n:58)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e24.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e45.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e32.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e97.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e256.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e201.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e1199.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e2768.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e2382.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e4.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e10.47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e9.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e25.50\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eFemale (n:13)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e25.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e19.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e29.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e192.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e242.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e112.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e2361.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e1764.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1145.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e7.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e5.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e25.58\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"3\" valign=\"top\"\u003e\n \u003cp\u003eEthnicity\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eCaucasian\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e24.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e40.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e33.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e117.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e275.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e199.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e1374.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e2443.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e2332.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e5.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e8.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e9.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e27.33\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eBlack\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e24.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e33.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e26.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e13.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e8.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e5.97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e871.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e550.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e390.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e2.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e3.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e2.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e22.73\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eHispanic or other\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e24.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e42.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e18.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e154.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e85.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e73.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e2156.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e4238.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e737.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e7.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e17.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e2.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e12.33\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"3\" valign=\"top\"\u003e\n \u003cp\u003eSmoking\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eNon Smoker\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e26.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e58.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e29.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e74.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e154.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e130.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e1497.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e2463.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e2380.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e5.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e12.52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e12.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e24.69\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026lt;10 packs\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e42.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e24.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e22.30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e81.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e258.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e88.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1585.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2757.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e916.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e6.74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e9.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e4.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e25.35\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026gt;10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e19.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e34.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e34.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e143.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e304.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e229.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1326.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2626.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e2229.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e4.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e8.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e26.25\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"3\" valign=\"top\"\u003e\n \u003cp\u003eAlcohol\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eNo Alcohol\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e29.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e60.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e43.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e57.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e158.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e86.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e1398.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e2733.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e1434.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e5.71\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e11.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e5.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e23.21\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eSocial\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e29.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e28.94\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e20.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e137.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e252.52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e266.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1334.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2210.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e3598.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e9.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e13.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e25.35\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eHeavy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e13.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e18.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e26.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e168.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e445.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e259.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1501.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2824.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1894.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e4.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e30.94\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"5\" valign=\"top\"\u003e\n \u003cp\u003eLocation of Tumor\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eTonsil\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e17.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e37.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e33.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e66.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e198.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e117.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e763.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e1661.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e1130.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e3.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e7.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e5.47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e23.86\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eBOT\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e15.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e38.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e30.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e126.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e189.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e192.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1025.94\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2126.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e2825.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e3.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e9.30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e10.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e26.54\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eSoft Palate\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e40.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e25.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e28.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e67.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e338.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1313.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2055.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e488.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e6.47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e10.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e3.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e22.04\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003ePosterior\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e35.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e99.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e31.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e194.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e312.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e278.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e3489.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e8285.52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1615.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e12.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e23.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e23.75\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eOverlap\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e41.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e31.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e37.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e127.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e579.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e452.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e2169.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e3695.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e3532.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e7.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e8.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e13.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e27.27\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"3\" valign=\"top\"\u003e\n \u003cp\u003eHPV\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003ePositive\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e25.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e37.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e27.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e100.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e189.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e170.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e1376.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e1696.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e2285.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e5.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e7.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e9.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e28.01\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eNegative\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e28.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e46.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e39.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e75.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e329.76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e154.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1256.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e3490.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1538.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e12.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e23.51\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003en/a\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e17.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e41.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e35.52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e184.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e289.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e257.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1658.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e3317.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e2538.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e12.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e9.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e24.51\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"4\" valign=\"top\"\u003e\n \u003cp\u003eDifferentiation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eWell\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e62.30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e7.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e.3636\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e75.94\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e1392.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e155.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e2459.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e6017.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e310.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e9.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e4.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e1.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e32.03\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eModerate\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e28.71\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e37.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e29.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e116.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e103.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e187.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1646.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e1495.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e3124.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e6.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e5.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e11.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e21.27\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003ePoor\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e18.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e50.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e41.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e95.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e252.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e154.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1205.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2881.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1719.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e4.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e11.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e23.78\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eUndifferentiated\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e14.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e38.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e27.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e137.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e256.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e222.52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1081.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2933.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1596.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e3.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e13.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e30.79\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"14\" valign=\"top\"\u003e\n \u003cp\u003eAJCC\u003c/p\u003e\n \u003cp\u003e7 Staging\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eT1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e37.53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e34.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e32.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e86.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e428.64\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e12.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e3057.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e2544.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e835.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e28.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e4.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e3.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e13.81\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eT2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e6.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e33.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e12.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e131.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e185.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e162.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e797.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2251.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e682.30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e3.52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e8.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e3.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e28.33\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eT3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e29.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e46.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e44.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e97.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e163.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e125.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1264.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2156.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e2832.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e4.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e9.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n 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\u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1527.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e3672.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e3256.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e14.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e10.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e26.79\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eN0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e29.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e23.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e32.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e95.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e522.64\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e113.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1512.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2870.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e6088.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e30.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e25.34\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eN1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e24.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e16.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e13.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e131.94\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e285.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e163.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1712.47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e1691.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e786.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e6.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e4.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e27.47\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eN2a\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e11.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e44.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e33.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e99.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e94.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e235.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n 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\u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e44.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e15.78\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e140.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e178.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e312.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1392.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e3041.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e2016.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n 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\u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e44.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e31.50\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1579.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2189.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e2529.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e9.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n 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valign=\"top\"\u003e\n \u003cp\u003e24.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e19.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e126.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e341.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e147.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1439.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e1156.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1025.47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e6.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e4.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e5.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e17.86\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eM0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e20.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e29.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e33.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e117.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e298.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e202.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1349.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2026.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1715.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e27.43\u003c/p\u003e\n \u003c/td\u003e\n 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valign=\"top\"\u003e\n \u003cp\u003e9684.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e492.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e29.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e3.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e25.51\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eMx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e26.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n 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width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e14.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e13.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e20.19\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"18\" valign=\"top\"\u003e\n \u003cp\u003eAJCC\u003c/p\u003e\n \u003cp\u003e8 Staging\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eT1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e37.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e34.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e32.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e86.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e428.64\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e12.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e3057.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e2544.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e835.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e11.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e4.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n 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\u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e797.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2251.12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e682.30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e3.52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e8.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e3.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e28.33\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eT3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e29.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e46.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e44.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e97.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e163.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e125.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1264.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2156.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e2832.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e4.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e9.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e12.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e27.28\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eT4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e24.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e45.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e33.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e135.52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e373.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e373.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1527.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e3672.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e3256.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e14.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e10.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e26.79\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eN0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e29.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e23.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e32.89\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e95.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e522.64\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e113.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1512.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2870.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e6088.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e30.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e25.34\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eN1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n 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width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e3.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e22.60\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eN2a\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e10.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e47.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e41.52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n 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width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e11.56\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eN2b\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e25.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e60.31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e11.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e128.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e221.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e652.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n 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\u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e56.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e104.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e152.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e58.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e44.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1921.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e1916.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e3673.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n 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\u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e261.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e35.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1161.97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e14162.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e2927.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e4.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e40.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e9.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e28.22\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eNx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e29.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e19.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e7.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e466.76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e376.52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e2.76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e2.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e15.00\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eN1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e36.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n 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width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e4.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e2.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e24.25\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eN2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e19.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e43.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e32.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e125.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e126.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e213.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e818.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e1605.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e2157.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e3.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e29.43\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eN3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e3.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e28.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e19.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e244.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e570.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e267.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1568.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e3788.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1243.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e13.59\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e33.00\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eN\u0026shy;\u0026shy;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e21.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e21.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e18.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e126.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e508.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e288.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1439.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e1501.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1674.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e6.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e5.74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e26.68\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eM0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e\u0026shy;20.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e29.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e33.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e117.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e298.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e202.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1349.87\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2026.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1715.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e27.43\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eM1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e41.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e158.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e28.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e38.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e169.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1013.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e9684.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e492.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e29.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e3.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e25.51\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eMx\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e26.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e62.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e27.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e144.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e71.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e169.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1824.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e3421.94\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e3765.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e14.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e13.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e20.19\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003eTreatment Intent\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eCurative\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e24.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e42.30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e32.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e106.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e249.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e187.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e1344.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e2523.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e2184.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e5.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e9.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e8.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e25.53\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003ePalliative\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e22.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e8.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e210.43\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e350.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e2145.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e4134.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e7.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e12.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e25.32\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"4\" valign=\"top\"\u003e\n \u003cp\u003ePrimary Treatment\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eChemoradiation\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e24.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e40.97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e32.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e130.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e278.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e236.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e1648.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e3098.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e2966.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e6.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e11.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e11.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e29.40\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eSurgery\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e22.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e41.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e31.29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e102.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e236.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e138.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1200.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2214.22\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1402.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e4.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e8.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e22.71\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eRT\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e53.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e11.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e884.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e6.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e22.03\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eChemo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e16.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e0.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e114.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e140.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e974.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e456.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e4.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e1.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e38.55\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"5\" valign=\"top\"\u003e\n \u003cp\u003eAdjuvant Treatment\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eNone\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e25.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e32.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e33.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e122.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e253.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e239.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e1644.82\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e2119.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e3056.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e6.16\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e8.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e11.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e27.65\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eCRT\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e20.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e43.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e32.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e113.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e248.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e143.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1202.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2309.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1438.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e4.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e9.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e20.54\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eSurgery\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e62.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e140.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e16.71\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e112.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e244.76\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e9.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1844.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e10391.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e506.74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e9.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e31.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e1.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e40.56\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eRT\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e30.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e23.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e13.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e425.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1009.05\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e4091.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e4.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e16.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e-\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e37.33\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eChemotherapy\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e2.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e1.53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e1.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e133.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e213.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e155.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e707.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e1638.09\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e419.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e3.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e5.80\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e2.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e40.27\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"3\" valign=\"top\"\u003e\n \u003cp\u003eMargin\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eNegative\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e24.52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e23.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e19.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e99.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e318.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e168.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e1150.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e1367.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e895.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e4.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e5.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e4.26\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e31.32\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003en/a\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e24.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e55.13\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e41.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e122.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e161.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e171.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1571.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e3133.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e2847.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e12.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e10.97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e25.28\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003ePositive\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e23.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e25.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e21.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e106.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e383.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e225.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1203.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2252.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1695.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e4.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e22.68\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"3\" valign=\"top\"\u003e\n \u003cp\u003eRecurrence\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e14.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e30.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e30.93\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e113.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e164.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e191.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e1044.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e1227.30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e2267.51\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e4.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e6.17\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e9.06\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e27.74\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e28.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e48.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e18.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e167.81\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e500.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e210.18\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1468.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e4531.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1222.10\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.21\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e15.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e5.91\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e28.12\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003en/a\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e36.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e118.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e91.94\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e72.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e201.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e48.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1990.49\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e8565.98\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e4194.39\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e7.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e24.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e12.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e20.16\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"4\" valign=\"top\"\u003e\n \u003cp\u003eLocation of Recurrence\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003ePrimary Site\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e21.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e38.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e26.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e252.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e437.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e98.01\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e1322.54\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e3557.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e909.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e3.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e10.47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e4.48\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e27.72\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eNeck\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e55.07\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e61.77\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e32.67\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e19.19\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e57.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e11.62\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1427.66\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e1354.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e775.20\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.33\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e3.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e26.98\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eBoth\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e4.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e62.65\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e4.94\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e240.94\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e839.74\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e380.83\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1603.75\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e7847.63\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1913.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e25.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e8.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e24.51\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003en/a\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e33.52\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e13.02\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e19.85\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e21.38\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e244.35\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e241.36\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1676.14\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e1959.92\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1070.04\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.41\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e8.15\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e6.68\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e41.02\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003eDeath\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e28.84\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e54.42\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e42.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e143.79\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e342.88\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e255.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e1650.57\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e3726.64\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e4025.86\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e5.97\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e13.53\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e15.00\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e25.79\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e21.40\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e33.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e26.61\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e95.24\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e205.23\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e152.47\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1256.99\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e1961.08\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e1238.27\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e4.95\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e7.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e5.44\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e25.38\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"8.976377952755906%\" rowspan=\"2\" valign=\"top\"\u003e\n \u003cp\u003eDeath of Disease\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"9.606299212598426%\" valign=\"top\"\u003e\n \u003cp\u003eYes\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e29.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e32.11\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e18.70\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e205.28\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e600.45\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e392.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e1857.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.456692913385827%\" valign=\"top\"\u003e\n \u003cp\u003e5031.72\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.984251968503937%\" valign=\"top\"\u003e\n \u003cp\u003e3361.56\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e6.34\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e16.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"5.669291338582677%\" valign=\"top\"\u003e\n \u003cp\u003e7.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.929133858267717%\" valign=\"top\"\u003e\n \u003cp\u003e32.61\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd width=\"10.55363321799308%\" valign=\"top\"\u003e\n \u003cp\u003eNo\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e27.96\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e76.73\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e56.69\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e77.90\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e85.32\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e175.58\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e1443.46\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.093425605536332%\" valign=\"top\"\u003e\n \u003cp\u003e2421.55\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.57439446366782%\" valign=\"top\"\u003e\n \u003cp\u003e4413.37\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e5.60\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e11.03\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"6.228373702422146%\" valign=\"top\"\u003e\n \u003cp\u003e19.25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd width=\"7.612456747404845%\" valign=\"top\"\u003e\n \u003cp\u003e20.07\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eTable 4: Inflammatory index values pretreatment, at 3 months, and at 6 months\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Oropharyngeal Cancer, Inflammatory Index, Cancer Survival","lastPublishedDoi":"10.21203/rs.3.rs-3830223/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3830223/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eInflammation has long been a key tenet in the diagnosis and management of malignancies, likely contributing to cancer incidence, staging, and progression. Systemic inflammation, in particular, is often elevated prior to and during cancer development. Systemic inflammation in the context of cancer diagnosis and monitoring is measured by various inflammatory indexes such as Systemic inflammatory response index (SIRI), plasma-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and neutrophil-to-lymphocyte ratio (NLR). We set out to determine the relationship between pre and posttreatment levels of these inflammatory indexes and the prognosis and outcomes of oropharyngeal cancer (OPC).\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003e A retrospective chart review was performed of 172 patients with OPC who underwent treatment for oropharyngeal cancer at University Medical Center between May 2013 to May 2023. Sites of primary cancer were obtained through chart review. HPV infection status and differentiation of the tumor were noted for each patient. Treatment modalities were classified as surgery, radiation, chemotherapy, or concurrent chemotherapy and radiation. Treatment outcomes were classified based on recurrence and death secondary to disease. The relationships between treatment outcome and the described inflammatory indexes were evaluated. Appropriate parametric tests were selected based on the large number of variables.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003ePretreatment SIRI and Albumin levels were positively predictive in determining locoregional recurrence (p\u0026thinsp;=\u0026thinsp;.031 and p\u0026thinsp;=\u0026thinsp;.039). NLR, SII, and SIRI levels taken at three months post-treatment were also found to be positively predictive of locoregional recurrence (p\u0026thinsp;=\u0026thinsp;.005, p\u0026thinsp;\u0026gt;\u0026thinsp;.0005, and p\u0026thinsp;=\u0026thinsp;.007). SIRI taken at six months post-treatment was also found to be positively predictive of locoregional recurrence (p\u0026thinsp;=\u0026thinsp;.008). SII at six months post-treatment was found to be positively predictive of survival (p\u0026thinsp;=\u0026thinsp;.027).\u003c/p\u003e\u003ch2\u003eConclusions\u003c/h2\u003e \u003cp\u003eThis study suggested that post-treatment levels of several inflammatory indexes, particularly SIRI, NLR, and SII, may be useful in determining the long-term outlook and recurrence of head and neck cancer following treatment.\u003c/p\u003e","manuscriptTitle":"The Effectiveness of Inflammatory Indexes in Assessing Oropharyngeal Cancer Prognosis","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-01-05 18:02:23","doi":"10.21203/rs.3.rs-3830223/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"e464b1c9-ff1e-4914-b93a-ea5e52154f65","owner":[],"postedDate":"January 5th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2024-01-08T03:29:14+00:00","versionOfRecord":[],"versionCreatedAt":"2024-01-05 18:02:23","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3830223","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3830223","identity":"rs-3830223","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}