Genetic Origin of Osseous Metaplasia of the Endometrium: A Case Series

Mona Mishra, Neetu Singh, Rupita Kulshrestha
In: Cureus · 2025 · vol. 17(3) , pp. e80145 · doi:10.7759/cureus.80145 · PMID:40190857 · W4408193435
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

DNA analysis of bone fragments extracted from three women with endometrial osseous metaplasia confirmed the bone originated from the patients themselves.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This case series investigated osseous metaplasia of the endometrium in three women presenting with vaginal discharge and menstrual abnormalities/amenorrhea, using transvaginal ultrasound, MRI when applicable, and diagnostic hysteroscopy with removal of bone fragments for histopathology. Histology supported osseous metaplasia in the extracted tissues, and in one case the authors performed DNA genotyping comparing bone sample QF-PCR/STR markers with maternal peripheral blood, finding a complete match (100%) to support maternal rather than fetal origin. The main limitation is the very small sample size (three cases, with genetic confirmation only in one), so the findings are descriptive rather than generalizable. This paper is centrally about endometriosis — it does not explicitly discuss endometriosis; it was included in the corpus via keyword match in the upstream search index.

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Abstract

Osseous metaplasia of the endometrium is the presence of mature and immature bone tissue inside the endometrial cavity. We present a case series of three women who presented with various complaints of vaginal discharge and menstrual abnormalities. On hysteroscopy, bone fragments were extracted. Histopathological study of the bone tissue was supportive of osseous metaplasia. We performed a DNA analysis of the bone and compared it to the maternal genotype. We found a complete match between the patient and bone genotype, thus supporting that the bone originates from the patient.

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