Role of macrophage cell in Lymphatic filariasis

Lymphatic filariasis (LF) is a chronic, neglected nematode parasite that infected filarial parasites. It is abundant in underprivileged communities across the globe. It is belonging to the group of rare neglected tropical diseases (NTD). After malaria, it is the leading infectious disease. Causative organisms Wuchereria bancrofti , Brugia malayi , and Brugia timori belong to the phylum Nematode. It affects billions of people in India and several other countries. They were asymptomatic, but now a day few symptoms have been observed such as lymphedema, elephantiasis and hydrocele. This disease shows close communication with humans by interacting with host immune systems. They disrupt monocytes/macrophages, dendritic cells, granulocytes, eosinophils, basophils, and Toll-like receptors. This review demonstrated macrophage cells’ (mɸs) role and their therapeutic approaches.