The Role of RNA Methylation Modification Related Genes in Prognosis and Immunotherapy of Colorectal Cancer

This study aimed to analyze the effects of RNA methylation regulatory genes in prognosis and treatment of CRC. Prognostic signature associated with CRCs were constructed by differential expression analysis, Cox and LASSO analyses. ROC and Kaplan-Meier survival analyses were used to validate the reliability of the developed model. Finally, normal and cancerous tissue were collected to validate gene by qRT-PCR. A prognostic risk model based on LRPPRC and UHRF2 was constructed and relevant to the OS of CRC. Ultimately, PCR validation showed that a significant upregulation in the expression of LRPPRC and UHRF2 in cancerous tissue. A prognostic risk model based on LRPPRC and UHRF2 was successfully built, and the model could predict the immunotherapy efficacy of CRC.