Role of Klf11 on lesion size in endometriosis.

(A) Endometriosis was surgically induced in 8 week old Klf11-/- and wildtype female mice (N = 7/group). All animals were weighed prior to initial surgery and at necropsy 3 weeks later. There was no difference in weight between the groups either prior to implantation surgery or before subsequent necropsy. Comparative weight profile prior to necropsy shown (p>0.05; NS). (B, C) At induction, 0.5cm endometrial implants were implanted on to the parietal peritoneum of Klf11-/- and wildtype mice. Lesion size was evaluated at necropsy three weeks after initial surgery. The peritoneal lesions (white arrows; box) in Klf11-/- mice (C) were larger and more cystic compared to those observed in wildtype controls (B). (D) The lesions in Klf11-/- animals (6.8±0.044mm) were significantly larger than those observed in wildtype controls (4.5 ± 0.029mm). [* = p<0.05; 14 lesions per genotype].