Successful treatment of a B/T MPAL patient by chemo-free treatment with Venetoclax,Azacitidine and Blinatumomab

B/T mixed phenotype acute leukemia (MPAL), which represents only 2-3% of all MPAL cases, is classified as a high-risk leukemia subtype. Adults diagnosed with B/T MPAL have a notably low three-year survival rate, estimated at 20–40%. The rarity and undercharacterization of B/T MPAL present substantial challenges in identifying an optimal treatment protocol. This report aims to shed light on this issue by presenting a case in which a patient with a complex karyotype was treated using a combination of Venetoclax, Azacitidine, and Blinatumomab. This novel, chemo-free regimen resulted in the patient achieving both hematologic and molecular complete remission , with no severe organ or hematological toxicity observed. Notably, the patient continued to maintain molecular remission for 1 years following the transplantation. Based on these findings, the combination of Venetoclax, Azacitidine, and Blinatumomab could be considered a potential therapeutic approach for B/T MPAL patients, meriting further investigation.