Some hitherto unreported findings on the extragenital effects of progesterone in human females--a clinical study.

40 women suffering from 'dysfunctional uterine bleeding' (DUB) were treated by progesterone (P) and signs and symptoms of 'extragenital effects' of P were noted. In addition to the previous ones reported from this laboratory, a new crop of effects, which, as far as we are aware of, have never been reported in the literature, were found and included: (i) Changes in the frequency of EEG waves, (ii) changes in the ECG (iii) changes in psychoanalytical scoring. Further (iv) with most of the parametres, the intensity of the changes showed considerable waning with passage time, despite the fact that the subjects were still receiving P. Blood P levels similarly fell considerably in the initial phase of the therapy, but recovered to some extent afterwards, despite the continuance of P therapy.