THE EFFECTS OF VAGOTOMY ON THE PHYSIOLOGY OF THE STOMACH IN PATIENTS WITH PEPTIC ULCER

Clarke JS, J S Clarke, E H Storer, Storer EH, Dragstedt LR, L R Dragstedt
The Journal of clinical investigation · 1947 · vol. 26(4) , pp. 784–95 · doi:10.1172/jci101861 · PMID:16695470 · PMC439287
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This 1947 study investigated the physiological changes in gastric function following vagotomy in patients suffering from peptic ulcers. The researchers, affiliated with the University of Chicago Department of Surgery, analyzed how cutting the vagus nerve affected stomach acid secretion and motility as a treatment mechanism for ulcer disease. The findings detailed the specific alterations in gastric physiology that resulted from this surgical intervention, providing insight into the neural control of digestive processes during that era. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Advertisement Research Article Free access | 10.1172/JCI101861 Department of Surgery of The University of Chicago 1This work has been aided by grants from Mr. Andrew E. Wigeland and from the Douglas Smith Foundation for Medical Research of The University of Chicago. Find articles by Clarke, J. in: PubMed | Google Scholar Department of Surgery of The University of Chicago 1This work has been aided by grants from Mr. Andrew E. Wigeland and from the Douglas Smith Foundation for Medical Research of The University of Chicago. Find articles by Storer, E. in: PubMed | Google Scholar Department of Surgery of The University of Chicago 1This work has been aided by grants from Mr. Andrew E. Wigeland and from the Douglas Smith Foundation for Medical Research of The University of Chicago. Find articles by Dragstedt, L. in: PubMed | Google Scholar Published July 1, 1947 - More info Published in Volume 26, Issue 4 on July 1, 1947 J Clin Invest. 1947;26(4):784–795. https://doi.org/10.1172/JCI101861. © 1947 The American Society for Clinical Investigation J Clin Invest. 1947;26(4):784–795. https://doi.org/10.1172/JCI101861. © 1947 The American Society for Clinical Investigation Published July 1, 1947 - Version history - Version history - Version 1 (July 1, 1947): No description Advertisement Advertisement Copyright © 2026 American Society for Clinical Investigation ISSN: 0021-9738 (print), 1558-8238 (online)

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MeSH descriptors

Peptic Ulcer Vagotomy Humans Peptic Ulcer

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