A rare case of metaplastic breast carcinoma from India: Towards precision oncology

Background: Metaplastic Breast Cancer (MpBC) is an exceedingly rare entity, accounting for less than 1% of all malignant breast tumours. Predominantly triple-negative, they are notorious for their chemoresistance, high rates of recurrence and decreased disease-free survival (DFS). All this contributes significantly to BC mortality and results in poor prognostic implications. Limited evidence has led to a lacuna of specific treatment guidelines for this entity and hence remains an uncharted territory for clinicians. Case : We report a case of left-sided low-grade metaplastic triple negative T3N2aM0 BC treated with neoadjuvant chemotherapy, primary surgery, and adjuvant radiotherapy, presently in remission. Conclusion : Limited experience in management of this pathological entity warrants the need for more research on it, with a special focus on targeted therapy. Discussing possibilities of a tailored approach, rather than a one-size-fits-all approach may aid in paving the path for the future of MpBC treatment.