Abstract
Aim: Efforts to mitigate underreporting have focused on the ability of different methods, independent of spontaneous reporting, to identify ADRs. However, there is limited data on the effectiveness of these methods in detecting ADRs of interest. In this study, we collected data on this issue using the ICD-10 codes we routinely employ to detect unreported ADRs. Methods: We defined ADRs of interest as those that were severe, involved biological agents or drugs under additional monitoring, affected a child, and were previously unknown, while providing sufficient data on both the reaction and the drug. We generated a list of all patients whose discharge reports included any of the selected codes. The medical records of these patients were manually reviewed to verify the presence of an ADR and determine whether it met the criteria for being of interest. Results: We observed a significant difference between a code’s ability to detect ADRs and its effectiveness in identifying ADRs of interest. Of the 50 codes analysed, 17 were useful in identifying ADRs of interest. Conclusions: There isn‘t a small set of codes that allow to identify interesting ADRs nor any ADR related code identifies an interesting ADR every time it appears. Every unit going to use this method to identify ADRs should previously explore the utility of each code, although the codes proposed by us seems to be a good starting point.
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Utility of some International Classification of Diseases 10th revision codes for detecting serious and interesting adverse drug reactions. | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 20 March 2025 V1 Latest version Share on Utility of some International Classification of Diseases 10th revision codes for detecting serious and interesting adverse drug reactions. Authors : Boada Fernández del Campo C 0000-0002-1087-9018 [email protected] , García Sánchez-Colomer M , Fernández Quintana E , and D. Fondevilla Batista Authors Info & Affiliations https://doi.org/10.22541/au.174250083.31006815/v1 199 views 130 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Aim: Efforts to mitigate underreporting have focused on the ability of different methods, independent of spontaneous reporting, to identify ADRs. However, there is limited data on the effectiveness of these methods in detecting ADRs of interest. In this study, we collected data on this issue using the ICD-10 codes we routinely employ to detect unreported ADRs. Methods: We defined ADRs of interest as those that were severe, involved biological agents or drugs under additional monitoring, affected a child, and were previously unknown, while providing sufficient data on both the reaction and the drug. We generated a list of all patients whose discharge reports included any of the selected codes. The medical records of these patients were manually reviewed to verify the presence of an ADR and determine whether it met the criteria for being of interest. Results: We observed a significant difference between a code’s ability to detect ADRs and its effectiveness in identifying ADRs of interest. Of the 50 codes analysed, 17 were useful in identifying ADRs of interest. Conclusions: There isn‘t a small set of codes that allow to identify interesting ADRs nor any ADR related code identifies an interesting ADR every time it appears. Every unit going to use this method to identify ADRs should previously explore the utility of each code, although the codes proposed by us seems to be a good starting point. Supplementary Material File (pds-25-0206-file001.docx) Download 39.21 KB Information & Authors Information Version history V1 Version 1 20 March 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords adverse drug reactions chart review coding international classificatión of diseases pharmacovigilance underreporting Authors Affiliations Boada Fernández del Campo C 0000-0002-1087-9018 [email protected] Servicio Canario de Salud View all articles by this author García Sánchez-Colomer M Servicio Canario de Salud View all articles by this author Fernández Quintana E Servicio Canario de Salud View all articles by this author D. Fondevilla Batista Hospital Universitario de Canarias View all articles by this author Metrics & Citations Metrics Article Usage 199 views 130 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Boada Fernández del Campo C, García Sánchez-Colomer M, Fernández Quintana E, et al. Utility of some International Classification of Diseases 10th revision codes for detecting serious and interesting adverse drug reactions.. Authorea . 20 March 2025. DOI: https://doi.org/10.22541/au.174250083.31006815/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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