A systematic study on blood system of immune mechanism of hand foot and mouth disease sepsis

Objective: In order to carry out clinical demonstration on the new viewpoint of immune mechanism of HFMD sepsis. Methods: This paper has collected 2014 EV71 between April and October 2017 hospitalized children with hand, foot and mouth disease, according to condition according to system group, according to the condition is divided into intensive (cure) and critical (death) group, choose the same outpatient health physical examination for children (health) in the control group, the above cases from small to large system into the immune system and immune system related group, The immune system group was subdivided into lymphocyte subgroup and lymphocytic neutrophil group. The percentage of CD3+T lymphocyte and CD19+B lymphocyte and the percentage of lymphocyte and neutrophil were measured respectively. The blood white blood cell count, C-reactive protein, blood glucose and platelet count were measured in immune-related system group. Compare the difference of detection data between different disease groups in each system group. Results: The percentage of CD3+T lymphocyte and CD19+B lymphocyte in lymphocyte subgroup was significantly different among the three groups (P<0.01). The percentage of lymphocyte and neutrophil in the lymphocyte neutrophil system group was significantly different among the three groups of patients with different diseases (P<0.01). There were significant differences in white blood cell count, C-reactive protein, blood glucose and platelet count among the three groups of patients with different conditions in immune-related system (P<0.01). Conclusion: The immune mechanism of HFMD sepsis from small to large follows the rule of system balance compensation among different system groups.