The new phthalic acid-based DES as a versatile catalyst for the synthesis of pyrimido[4,5-d]pyrimidines and pyrano[3,2-c]chromenes

The new phthalic acid-based DES as a versatile catalyst for the synthesis of pyrimido[4,5-d]pyrimidines and pyrano[3,2-c]chromenes | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article The new phthalic acid-based DES as a versatile catalyst for the synthesis of pyrimido[4,5-d]pyrimidines and pyrano[3,2-c]chromenes Arezo Monem, Davood Habibi, Abdolhamid Alizadeh, Hadis Goudarzi This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3876795/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Deep eutectic solvents (DESs) have found many applications in recent years and with countless advantages over regular solvents, not only complying with green chemistry principles but also acting as catalysts depending on their properties. In this regard, a new DES (MTPPBr-PHTH-DES) was prepared from a mixture (molar ratio 1:1) of methyltriphenylphosphonium bromide (MTPPBr) and phthalic acid (PHTH), characterized with various techniques such as FT-IR, TGA/DTA, densitometer, eutectic point, and 1 H NMR and used as an acid catalyst in the synthesis of pyrimido[4,5- d ]pyrimidines and pyrano[3,2- c ]chromes in solvent-free conditions. Short reaction time, high efficiency, and easy recycling and separation of the DES catalyst are among the most important features of the presented method. Physical sciences/Chemistry Physical sciences/Materials science Methyltriphenylphosphonium bromide phthalic acid DES pyrimidopyrimidines pyranochromenes Full Text Additional Declarations No competing interests reported. Supplementary Files SuppInfoMonem5ndmanusSciRep18Jan.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3876795","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":268338267,"identity":"266f2ebc-86b1-41e5-bb73-a31f32f1f1ce","order_by":0,"name":"Arezo Monem","email":"","orcid":"","institution":"Bu-Ali Sina University","correspondingAuthor":false,"prefix":"","firstName":"Arezo","middleName":"","lastName":"Monem","suffix":""},{"id":268338268,"identity":"42849fae-1760-4ce6-b9d8-3e7aaa26409c","order_by":1,"name":"Davood Habibi","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA7klEQVRIiWNgGAWjYDCCAyCCjSGBQYKxjSGhAshhZm4gRcsZkBZGorUASaAuICCghe/4GcMHH8oY8vhnN7c9eDivNpq/HajlR8U2nFokz+QYG844x1Ascedgu0HituO5Mw4zNjD2nLmNU4vBgbQ0ad42hsSGG4ltEonbjuU2ALUwM7bh0XL+GUTLfLCWOcdy5xPUciP5GFjLBrCWhprcDYS0SN54fBjoF4nEjSC/JBw7kLsRqOUgPr/wnU9sBIaYTeK82+3PHv6oqcudd/7wwQc/KnBrgQIJGOMwmDxASD0yqCNF8SgYBaNgFIwQAAAXgWSTSWylsgAAAABJRU5ErkJggg==","orcid":"","institution":"Bu-Ali Sina University","correspondingAuthor":true,"prefix":"","firstName":"Davood","middleName":"","lastName":"Habibi","suffix":""},{"id":268338269,"identity":"5b790298-0958-4b22-ab78-338b94be5695","order_by":2,"name":"Abdolhamid Alizadeh","email":"","orcid":"","institution":"Alzahra University","correspondingAuthor":false,"prefix":"","firstName":"Abdolhamid","middleName":"","lastName":"Alizadeh","suffix":""},{"id":268338270,"identity":"861fd1ae-f727-4806-bda2-2fa9f11ae9db","order_by":3,"name":"Hadis Goudarzi","email":"","orcid":"","institution":"Bu-Ali Sina University","correspondingAuthor":false,"prefix":"","firstName":"Hadis","middleName":"","lastName":"Goudarzi","suffix":""}],"badges":[],"createdAt":"2024-01-18 20:14:13","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3876795/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3876795/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":50729148,"identity":"93539e8f-0cd8-49e8-bf7c-b97b9b825dd2","added_by":"auto","created_at":"2024-02-06 12:23:13","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1361424,"visible":true,"origin":"","legend":"","description":"","filename":"Monem5thManusSciRep18Jan.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3876795/v1_covered_483613d6-f33d-4d0e-a105-d0dc843bca27.pdf"},{"id":50033553,"identity":"8ef1865f-2f2c-4bb8-b7f0-afd9dfaed32c","added_by":"auto","created_at":"2024-01-23 13:02:36","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":7271213,"visible":true,"origin":"","legend":"","description":"","filename":"SuppInfoMonem5ndmanusSciRep18Jan.docx","url":"https://assets-eu.researchsquare.com/files/rs-3876795/v1/da64bd11c33310e09fc1ca18.docx"}],"financialInterests":"No competing interests reported.","formattedTitle":"The new phthalic acid-based DES as a versatile catalyst for the synthesis of pyrimido[4,5-d]pyrimidines and pyrano[3,2-c]chromenes","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Methyltriphenylphosphonium bromide, phthalic acid, DES, pyrimidopyrimidines, pyranochromenes","lastPublishedDoi":"10.21203/rs.3.rs-3876795/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3876795/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eDeep eutectic solvents (DESs) have found many applications in recent years and with countless advantages over regular solvents, not only complying with green chemistry principles but also acting as catalysts depending on their properties. 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