Astrocyte-Induced Dynamics of a Pyramidal Cell with a Dendrite-Connected Astrocyte

Astrocyte-Induced Dynamics of a Pyramidal Cell with a Dendrite-Connected Astrocyte | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Astrocyte-Induced Dynamics of a Pyramidal Cell with a Dendrite-Connected Astrocyte Lenka Přibylová, Jan Ševčík, Anastasia Egorova, Štěpán Husa, Lucia Kajanová, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6837986/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 10 Mar, 2026 Read the published version in Journal of Computational Neuroscience → Version 1 posted 10 You are reading this latest preprint version Abstract Previous multi-parameter bifurcation analyses of the Pinsky--Rinzel neuron model have elucidated a mechanistic explanation for the complex interplay between the membrane potentials of CA3 pyramidal cells and their intracellular dendritic calcium levels. By coupling this neuron model with the Li--Rinzel astrocyte model at the dendritic compartment, we demonstrate how astrocytic calcium signaling dynamically modulates neuronal activity. We present a classification of potential dynamical transients, including transitions to epileptiform activity. Furthermore, we identify a bidirectional role of astrocytes where they may not only facilitate the emergence of high-frequency oscillations associated with epileptiform activity but may also contribute to their attenuation. Additionally, we propose a mechanism that prolongs the bursting duration of pyramidal cells, which may be associated with synaptic plasticity. These findings enhance our understanding of integrated neural circuit dynamics, particularly the role of neuron--astrocyte interactions in modulating bursting behavior, neural signaling, and their potential contribution to both the generation and suppression of epileptiform ripples. pyramidal cell astrocyte epileptiform activity Pinsky--Rinzel model Li--Rinzel model Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 10 Mar, 2026 Read the published version in Journal of Computational Neuroscience → Version 1 posted Editorial decision: Revision requested 13 Oct, 2025 Reviews received at journal 12 Oct, 2025 Reviews received at journal 09 Oct, 2025 Reviewers agreed at journal 07 Oct, 2025 Reviewers agreed at journal 10 Sep, 2025 Reviewers agreed at journal 25 Jun, 2025 Reviewers invited by journal 16 Jun, 2025 Editor assigned by journal 09 Jun, 2025 Submission checks completed at journal 09 Jun, 2025 First submitted to journal 06 Jun, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6837986","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":472195557,"identity":"b43571b6-84ab-45c3-a706-b182045afa38","order_by":0,"name":"Lenka 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