Evaluation of the relationship between hyperemesis gravidarum with Platelet crit, hemoglobin to red cell distribution width ratio and Neutrophil to lymphocyte ratio

Abstract Introduction:This study, it was aimed to investigate the relationship between the severity of hyperemesis gravidarum (HEG) disease and subclinical inflammatory factors such as Platelet crit (PCT), Hemoglobin to red cell distribution width ratio (HRR), Neutrophil to lymphocyte ratio (NLR), which are known to be closely associated with inflammation in patients with hyperemesis gravidarum.Material method: This retrospective case control study was conducted between December 2020 and December 2021. A total of 215 pregnant women, 102 with hyperemesis gravidarum and 113 healthy pregnant women, were included in the study. HEG patients were divided into three groups according to the modified PUQE classification as mild (n = 38), moderate (n = 32), and severe (n = 32).Results: PCT, HRR, and, NLR values were found to be statistically significantly higher in the HEG group compared to the control group (p < 0.05). PCT, HRR, and, NLR values increase from mild to severe in HEG patients (p < 0.05). There was a positive correlation between HEG and PCT (rho = 0.70, p < 0.001), HRR (rho = 0.28, p < 0.04), NLR (rho = 0.60, p < 0.001) values. Logistic regression analysis revealed that a one-unit increase in PCT, HRR, and NLR resulted in a 2.14, 1.41, and 2.36-fold increase in HEG risk, respectively.Conclusion: PCT, HRR and NLR are inflammatory markers that increase in patients with HEG and have predictive value for the development of HEG. In our study, we suggested the use of a new prognostic marker for patients with HEG. We think that our study will be a source for future studies on HEG.