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Synonyms
Choristoma of Müllerian-type tissue (Batt et al. 2007) (not recommended).
Definition
Müllerianosis is a rare tumor-like entity consisting of an admixture of endocervical, tubaric or endometrial epithelium, with at least two epithelial types present to qualify for the diagnosis of Müllerianosis. The lesion was first described in 1996 by Clement and Young.
Clinical Features
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Incidence
Müllerianosis of the urinary tract is a rare lesion and it occurs in approximately 1% of women with endometriosis; the bladder is the organ most frequently involved (Raspollini and Lopez-Beltran 2019). Its pathogenesis is still a source of debate ranging between an embryological origin, metaplasia, and implantation during surgery.
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Age
Müllerianosis affects mainly reproductive age women.
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Sex
It is a finding mainly in women. Uncommon cases may occur in male patients under long-term estrogen therapy.
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Site
This lesion occurs mainly in the dome or posterior wall of the urinary bladder.
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References and Further Reading
Batt, R. E., Smith, R. A., Buck Louis, G. M., et al. (2007). Mullerianosis. Histology and Histopathology, 22, 1161–1166.
Branca, G., & Barresi, V. (2014). Müllerianosis of the urinary bladder: A rare tumor-like lesion. Archives of Pathology & Laboratory Medicine, 138, 432–436.
Clement, P. B., & Young, R. H. (1996). Mullerianosis of the urinary bladder. Modern Pathology, 9, 731–737.
Maggiore, U. L. R., Ferrero, S., Candiani, M., et al. (2017). Bladder endometriosis: A systematic review of pathogenesis, diagnosis, treatment, impact on fertility, and risk of malignant transformation. European Urology, 71, 790–807.
Raspollini, M. R., & Lopez-Beltran, A. (Eds.). (2019). Gynecologic and urologic pathology: Similarities, differences and challenges. Cambridge: Cambridge University Press. https://doi.org/10.1017/9781316756423. Chapter 26 – Mullerian Lesions of the Bladder: Endometriosis, Endosalpingiosis, Endocervicosis, and Mullerianosis.
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Henriques, V., Raspollini, M.R., Lopez-Beltran, A. (2019). Mullerianosis. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4853-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_4853-1
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Publisher Name: Springer, Cham
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Online ISBN: 978-3-319-28845-1
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