Mullerianosis

Vanessa Henriques, Maria Rosaria Raspollini, Antonio López-Beltrán
In: Encyclopedia of Pathology · 2019 · pp. 1–3 · doi:10.1007/978-3-319-28845-1_4853-1 · W4244071522
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Müllerianosis is a rare tumor-like lesion characterized by an admixture of at least two epithelial types from endocervical, tubaric, or endometrial tissue, typically found in women of reproductive age.

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Müllerianosis is defined as a rare tumor-like entity characterized by an admixture of at least two types of Müllerian epithelium, such as endocervical, tubaric, or endometrial tissue. Although it primarily affects women of reproductive age and most frequently involves the urinary bladder, its exact pathogenesis remains debated among embryological origin, metaplasia, and surgical implantation. The lesion occurs in approximately 1% of women diagnosed with endometriosis, highlighting a significant histological overlap between these conditions. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Synonyms Choristoma of Müllerian-type tissue (Batt et al. 2007) (not recommended). Definition Müllerianosis is a rare tumor-like entity consisting of an admixture of endocervical, tubaric or endometrial epithelium, with at least two epithelial types present to qualify for the diagnosis of Müllerianosis. The lesion was first described in 1996 by Clement and Young. Clinical Features - Incidence Müllerianosis of the urinary tract is a rare lesion and it occurs in approximately 1% of women with endometriosis; the bladder is the organ most frequently involved (Raspollini and Lopez-Beltran 2019). Its pathogenesis is still a source of debate ranging between an embryological origin, metaplasia, and implantation during surgery. - Age Müllerianosis affects mainly reproductive age women. - Sex It is a finding mainly in women. Uncommon cases may occur in male patients under long-term estrogen therapy. - Site This lesion occurs mainly in the dome or posterior wall of the urinary bladder. - ... References and Further Reading Batt, R. E., Smith, R. A., Buck Louis, G. M., et al. (2007). Mullerianosis. Histology and Histopathology, 22, 1161–1166. Branca, G., & Barresi, V. (2014). Müllerianosis of the urinary bladder: A rare tumor-like lesion. Archives of Pathology & Laboratory Medicine, 138, 432–436. Clement, P. B., & Young, R. H. (1996). Mullerianosis of the urinary bladder. Modern Pathology, 9, 731–737. Maggiore, U. L. R., Ferrero, S., Candiani, M., et al. (2017). Bladder endometriosis: A systematic review of pathogenesis, diagnosis, treatment, impact on fertility, and risk of malignant transformation. European Urology, 71, 790–807. Raspollini, M. R., & Lopez-Beltran, A. (Eds.). (2019). Gynecologic and urologic pathology: Similarities, differences and challenges. Cambridge: Cambridge University Press. https://doi.org/10.1017/9781316756423. Chapter 26 – Mullerian Lesions of the Bladder: Endometriosis, Endosalpingiosis, Endocervicosis, and Mullerianosis. Author information Authors and Affiliations Corresponding author Editor information Editors and Affiliations Rights and permissions Copyright information © 2019 Springer Nature Switzerland AG About this entry Cite this entry Henriques, V., Raspollini, M.R., Lopez-Beltran, A. (2019). Mullerianosis. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_4853-1 Download citation DOI: https://doi.org/10.1007/978-3-319-28845-1_4853-1 Received: Accepted: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-319-28845-1 Online ISBN: 978-3-319-28845-1 eBook Packages: Living Reference MedicineReference Module Medicine

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