Network Pharmacology Approach for Predicting Targets of Zishen Yutai Pills on Premature Ovarian Insufficiency

Yihui Feng, Xinyi Chai, Ying-Yin Chen, Yan Ning, Ying Zhao
In: Evidence-Based Complementary and Alternative Medicine · 2021 · vol. 2021 , pp. 1–15 · doi:10.1155/2021/8215454 · PMID:34394393 · W3189992049
article OA: hybrid CC0 ⤵ 2 in-corpus citations
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This network pharmacology study identified 476 target genes for Zishen Yutai Pills in treating premature ovarian insufficiency, implicating inflamm-aging and glucose metabolism, potentially via the HIF-1 signaling pathway.

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Abstract

METHODS: A comprehensive strategy based on several Chinese herb databases and chemical compound databases was established to screen active compounds of ZSYTP and predict target genes. For network pharmacological analysis, network construction and gene enrichment analysis were conducted and further verified by molecular docking. RESULTS: A total of 476 target genes of ZSYTP were obtained from 205 active compounds. 13 herbs of ZSYTP overlapped on 8 active compounds based on the compound-target-disease network (C-T network). 20 biological processes and 9 pathways were strongly connected to the targets of ZSYTP in treating POI, including negative regulation of gene expression, mRNA metabolic process, hypoxia-inducible factor 1 (HIF-1) signaling pathway, and gluconeogenesis. Finally, molecular docking was visualized. CONCLUSION: Intriguingly, the signal pathways and biological processes uncovered in this study implicate inflamm-aging and glucose metabolism as potential pathological mechanisms of POI. The therapeutic effect of ZSYTP could be mediated by regulating glucose metabolism and HIF-1 signal pathway. Collectively, this study sheds light on the therapeutic potential of ZSYTP on POI.

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