Evaluation of effectiveness of advanced platelet rich fibrin (A-PRF) with demineralized freeze-dried bone allograft (DFDBA) placed into fresh extraction sockets with immediate implant placement: A clinical and radiographic study

Background: Dental implant placement has evolved over time with the introduction of numerous novel protocols. Following tooth extraction throughout the healing phase, alveolar ridge resorption is a potential issue that can be mitigated by the utilisation of a variety of techniques, one of which is the placement of immediate implants. The immediate implant treatment protocol offers numerous benefits, such as minimal surgical procedures, which thereby reduce overall treatment time, preserve bone height, and produce better aesthetic results, particularly in the anterior region. Such protocols have made implant insertion so much easier that results can now be anticipated more precisely. The distance between the lateral surface of an implant and surrounding alveolus is known as the jumping gap distance (JGD). JGD of >1.5 mm affects spontaneous bone healing. Research incorporating biomaterials such as membranes produced from blood and bone grafts has significantly contributed to the success of this therapy. Methods: : This research will be carried out over the course of a year. Twelve implants will be placed in systemically healthy individuals with one tooth/teeth in the maxilla and/or mandible indicated for extraction. Using a two-stage protocol, implant placement will be done simultaneously after extraction along with augmentation with A-PRF and DFDBA. The second stage surgery will be conducted three months after implant placement. Within 3-6 weeks, abutments will be connected and the final prosthesis will be placed. Expected results: Crestal bone changes and implant stability after using of A-PRF and DFDBA will serve as indicators to determine the implant's success after 6 months. Conclusion: The augmentation procedures have shown to be successful in obtaining bone fill and in resolving bone defects that are present in proximity with implants. An immediate implant placement along with bone augmentation may decrease resorption of horizontal bone. Trial registration: REF/2023/03/064371.