Effects of the repetitive administration of progesterone by nasal spray in postmenopausal women

Ettore Cicinelli, Mauro Cignarelli, Leonardo Resta, P. Scorcia, Donata Petruzzi, Giuseppe Santoro
In: Fertility and Sterility · 1993 · vol. 60(6) , pp. 1020–1024 · doi:10.1016/s0015-0282(16)56403-6 · PMID:8243679 · W2402106494
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This study investigated the effects of repeatedly administering progesterone via nasal spray to postmenopausal women.

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Abstract

ObjectiveTo study the effects of 10 days of nasal spray P treatment on P serum levels and the endometrium.DesignProspective.SettingUniversity Medical School.PatientsEight postmenopausal women received oral conjugated estrogens at a daily dose of 0.625 mg for 4 weeks immediately before vaginal surgery for prolapse. For the first 9 of the last 10 days the patients also received a nasal spray dosage of 11.2 mg P three times a day; on the 10th day they received only one dose.Main outcome measuresBlood samples were taken at 8:00 A.M. on treatment days 1, 3, 5, 7, 10, and 11 to follow P serum concentration levels. Endometrial samples for histologic examination were collected before P administration and immediately after surgery to evaluate the end-organ effect.ResultsMean P serum levels increased sixfold after 9 days of nasal spray P administration [from 0.612 +/- 0.280 ng/mL (1.958 +/- 0.896 nmol/L) to 3.925 +/- 1.553 ng/mL (12.560 +/- 4.970 nmol/L)] and declined thereafter, returning to the before treatment levels 24 hours after the last administration. In all subjects, the first histologic evaluation showed proliferative endometrium; the second showed clear secretive changes.ConclusionsRepetitive nasal spray P administration for 10 days in postmenopausal women led to increasing P serum levels and, when the estrogen stimulation was adequate, to secretory changes in the endometrium (end-organ effect).

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