Impact of Age for Overall Survival in Head and Neck Sarcoma

Background: ： The association between age and survival outcomes in head and neck sarcoma (HNS) has yet to be fully investigated due to rare tumor. To research the association between age at surgery and survival outcomes of patients with HNS. Methods: : Twenty-six patients with HNS who underwent by surgery from 2003 to 2017 were retrospectively enrolled. The association between clinicopathological parameters and age was assessed by Mann-Whitney U test, and the optimal cut-off age at surgery for predicting death was determined by receiver operating curve analysis. Log-rank test and Cox proportional hazards model were used for survival analyses. Results: : Patients who did not undergo chemotherapy were significantly older age at surgery. Fifty-five was the cut-off age that predicted death. Shorter survival rates of overall, disease-specific, local recurrence-free and disease-free were associated with older age. Age (≥ 55 years/< 55 years) was correlated with shorter overall survival by multivariate analysis adjusting with chemotherapy (absence/presence). Conclusion: Older age predicts worse overall survival in HNS.