Endometrial thickness after menopause: effect of hormone replacement.
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Abstract
Ultrasound (US) images of the pelvis were evaluated in 112 asymptomatic postmenopausal women to investigate the normal range of endometrial thickness (double-layer measurement) and the effect of hormone replacement on these measurements. Twenty-one patients (19%) had endometrial thickness greater than 0.8 cm. One patient, with an endometrial thickness of 2.5 cm, had endometrial carcinoma. Consideration of the known actions of estrogen and progestogen on the endometrium led the authors to believe that the clinical significance of an endometrium measuring more than 0.8 cm depends on the patient's hormonal status. Among asymptomatic postmenopausal women with an endometrial thickness between 0.8 and 1.5 cm, those receiving unopposed estrogen or continuous estrogen and progestogen need to undergo dilatation and curettage (D&C) or biopsy and those receiving no hormones or receiving sequential estrogen and progestogen should be encouraged to undergo D&C or biopsy. If a patient in one of the latter two groups is unwilling to undergo an invasive procedure, then US examination at 3-month intervals is acceptable. Any patient with endometrial thickness of at least 1.5 cm should undergo histologic diagnosis, regardless of symptoms or hormone status.
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Cited by (11)
- Postmenopausal vaginal bleeding in women using hormone replacement therapy 2012
- Radiological Reasoning: Algorithmic Workup of Abnormal Vaginal Bleeding with Endovaginal Sonography and Sonohysterography 2008
- Imagerie des méno-métrorragies 2008
- US of Abnormal Uterine Bleeding 2003
- Abnormal uterine cavity: differential diagnosis with MR imaging 1999
- Ultrasonographic measurement of endometrial thickness during hormonal replacement therapy in postmenopausal women 1998
- Magnetic Resonance Imaging Versus Ultrasound in the Assessment of Benign Uterine Lesions 1998
- Transvaginal ultrasonographic measurement of endometrial thickness in postmenopausal women receiving estrogen replacement therapy 1997
- Endometrial status in post-menopausal women on long-term continuous combined hormone replacement therapy (Kliofem®) a comparative study of endometrial biopsy, outpatient hysteroscopy and transvaginal ultrasound 1997
- Endometrial ablation: Post-operative pain, sonographic findings, management and outcome 1994
- Peri- and Postmenopausal Abnormal Bleeding 1994
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