Effect of pregnancy on endometriotic lesion histology.

Mariela Andrea Bilotas (730832), Carla Noemí Olivares (730833), Analía Gabriela Ricci (730834), Juan Ignacio Baston (730835), Tatiana Soledad Bengochea (730836), Gabriela Fabiana Meresman (730837), Rosa Inés Barañao (730838)
2015 · doi:10.1371/journal.pone.0124900.g004 · W6941641913
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This study utilized a mouse model with surgically induced endometriosis to investigate the histological changes in ectopic lesions during pregnancy. Researchers compared tissue sections from non-pregnant mice with those sacrificed at day 18 of gestation, observing distinct morphological alterations in the latter group. The findings revealed that pregnant lesions exhibited necrotic and infiltrated zones rich in inflammatory cells, alongside decidualized stroma featuring large polygonal cells with pale cytoplasm. Additionally, the analysis identified signs of endometrial involution characterized by flattened or absent glandular epithelium. This paper is centrally about endometriosis — specifically examining how pregnancy affects the histological structure of endometriotic lesions in an animal model.

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Abstract

Mice with surgical induced endometriosis were mated and sacrificed at day 18 of pregnancy. Micrographs show representative histological sections of endometriotic lesions from non pregnant (A-C) and pregnant mice (D-I). Asterisks show necrotic zones and black arrows infiltrated zones, both characterized by the presence of inflammatory cells. White arrows indicate a decidualized stroma, characterized by the presence of large polygonal cells with a pale pink cytoplasm and a large round or oval nucleus. Arrowheads show endometrial involution, recognized by the presence of a flattened-glandular-epithelium or the lack of one. The white boxes are shown at a higher magnification to the right. (A, D, G: 40X; B, E, H: 100X; C, F, I: 400X). Scale bar indicates 100 μm.
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Interplay between Endometriosis and Pregnancy in a Mouse Model Fig 4 Effect of pregnancy on endometriotic lesion histology. Mice with surgical induced endometriosis were mated and sacrificed at day 18 of pregnancy. Micrographs show representative histological sections of endometriotic lesions from non pregnant (A-C) and pregnant mice (D-I). Asterisks show necrotic zones and black arrows infiltrated zones, both characterized by the presence of inflammatory cells. White arrows indicate a decidualized stroma, characterized by the presence of large polygonal cells with a pale pink cytoplasm and a large round or oval nucleus. Arrowheads show endometrial involution, recognized by the presence of a flattened-glandular-epithelium or the lack of one. The white boxes are shown at a higher magnification to the right. (A, D, G: 40X; B, E, H: 100X; C, F, I: 400X). Scale bar indicates 100 μm.

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