10-Year-Childhood Malignancy Profile Province-Wide in Indonesia (2009- 2018): Yogyakarta Pediatric Cancer Registry

Background: This study aims to present an epidemiological profile of childhood malignancies diagnosed in Dr. Sardjito General Hospital from January 2009 to December 2018 and compare it with previous study 1 . Methods Childhood cancer was diagnosed in children aged 0–18 years, from January 2009 to December 2018, and analyzed. Childhood malignancies were categorized based on age, sex, and disease group according to the International Classification of Childhood Cancer. An estimated annual average incidence rate of childhood cancer was calculated. We visualized the number of patients and their regions of origin by geographic mapping. Results There were 1,788 new cases registered in Yogyakarta Pediatric Cancer Registry during the study period. The mean age at diagnosis was 6.3 years old with male-to-female ratio 1.4:1.0. Of these 56% of cancers were diagnosed in the age group of 0–5 years old. The most common diagnosis category was leukemia, which accounted for 60% of all childhood malignancies. The three most common diagnoses included: acute lymphoblastic leukemia (44%), acute myeloid leukemia (13%), and retinoblastoma (6%). The annual average incidence rate of leukemia and solid tumors was 26.8 and 17.5 per million, respectively. Conclusions There was an increase 60% in the number of childhood malignancies in 2009–2018 compared to the 2000–2009 study. The number of patients referred to our hospital increased, indicating a better registry, better referral system and better access to health care facility due to Universal Health Coverage.