THE VALUE OF PERIPHERAL BLOOD NK CELLSAND EXPRESSION OF TRANSFORMING GROWTH FACTOR BETA-1 IN RECURRENT OVARIANENDOMETRIOSIS

Nicole N. Petrovskaya, Victoria A. Pechenikova
In: Journal of Volgograd State Medical University · 2022 · vol. 19(4) , pp. 157–161 · doi:10.19163/1994-9480-2022-19-4-157-161 · W4320025353
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Recurrent endometriosis was associated with significantly reduced peripheral blood NK cells and increased TGF-β1 expression in endometrioma tissue.

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The paper evaluated whether peripheral blood natural killer (NK) cells and transforming growth factor beta-1 (TGF-β1) expression are associated with recurrent ovarian endometriosis. Using a study of patients with recurrent ovarian endometriosis, the authors assessed NK cell parameters in peripheral blood and measured TGF-β1 expression, reporting findings that link altered immune cell status and TGF-β1 with recurrence. A key limitation is that, based on the available text, detailed methods, comparison groups, sample size, and statistical approaches are not specified here, constraining interpretation of the strength of the associations. This paper is centrally about endometriosis — specifically recurrent ovarian endometriosis and how peripheral NK cells and TGF-β1 expression relate to recurrence.

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Abstract

Affiliation.Federal state budgetary educational institution of higher education «North-Western State Medical University named after I. I. Mechnikov» under the Ministry of Health of the Russian Federation, Saint-PetersburgIntroduction.Elevated level of transforming growth factor-β1 (TGF-β1) can be the cause of impaired immune response among women with endometriosis due to its ability to reduce the activity of NK-cells, which contributes to the survival of ectopic endometrial cells in the abdominal cavity and plays a key role in the progression of the disease.Materials and methods.196 endometrioma observations were studied, an immunological study of peripheral blood was performed with the determination of CD3-CD16/56+(natural killers) and an IHC study of the expression of TGF-β1 in the capsuleof an endometrioid cyst and in a preserved cytogenic stroma. Results.The IHC study showed that the expression area of TGF-β1 was significantly larger in the surgical material in the recurrent course of endometriosis; an immunological study revealed a significant decrease in NKcells during the endo-metrioma recurrence.Conclusion:Further study of the relationship between TGF-β1 and NK cells may be important as prognostic markers of recurrent endometriosis.
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THE VALUE OF PERIPHERAL BLOOD NK CELLS AND EXPRESSION OF TRANSFORMING GROWTH FACTOR BETA-1 IN RECURRENT OVARIAN 157 ENDOMETRIOSIS - PDF (Russian) Copyright (c) 2022 Petrovskaya N.N., Pechenikova V.A. This work is licensed under a Creative Commons Attribution 4.0 International License. СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор). Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 79562 от 27.11.2020 г. Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 79562 от 27.11.2020 г.

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endometriosisendometrioma

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