CHRONIC NICHE INFLAMMATION IN ENDOMETRIOSIS-ASSOCIATED INFERTILITY: CURRENT UNDERSTANDING AND FUTURE THERAPEUTIC STRATEGIES.

It is defined as the formation of endometrial tissue outside the urine cavity in estrogen-dependent inflammation condition is known as endometriosis that affects 10% of females at childbearing age and contributes up to 50% cases of infertility. It has an awful association with assisted reproductive technology inclusive low implantation and pregnancy rates. To treat infertility originated with endometriosis required a deep understanding of its pathology. In this article we have discussed the chronic niche inflammation in endometriosis development, targeting inflammation for treatment of endometriosis-associated infertility, and stem cell therapy. Moreover, mesenchymal stem cell-based treatments are highlighted as potential endometriosis therapy.