Immunocytes and cell-mediated immunity in the pathology of reproduction

K Nouza, R Kinsky, M Petrovská, D Dimitorv, R Sedlák, J Laitl, J Presl
Advances in experimental medicine and biology · 1995 · doi:10.1007/978-1-4615-1941-6_77 · PMID:8525946
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This study investigated the dynamic distribution of leukocytes within the human corpus luteum using immunoperoxidase staining and computer-assisted image analysis to understand immune cell roles in its lifespan.

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This chapter reviews how the immune system maintains tolerance to developing germ cells in the highly immunologically regulated reproductive system, and presents new observations on immune involvement in human corpus luteum (hmCL). Using immunoperoxidase staining and computer-assisted image analysis, the authors studied the dynamic distribution of leukocytes within different hmCL structures across the luteal lifespan. They report that leukocyte localization changes over time in association with hmCL development and regression, addressing that the immune system’s role in ovarian control remains incompletely proven. This paper does not specifically discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The reproductive system is from the immunological point of view highly heterogeneous and sophistically regulated. The germinative central organs hold a privileged status: they must guarantee full tolerance of developing and mature male and female germinal cells. This tolerance is secured by anatomical barriers and complex immunoregulatory mechanisms.1 General ovarian functions, as well as the particular development and functional maturation and regression of the human corpus luteum (hmCL) are under the well-known strict neuroendocrine control. The roles played by the immune system in ovarian control have been hypothetically outlined2, but they are still incompletely proven. To understand better the roles of immune cells and their products during the whole life span of hmCL we have studied, using the immunoperoxidase method and its evaluation by computer-assisted image analysis, the dynamic distribution of leukocytes within various structures of the hmCL. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Preview Unable to display preview. Download preview PDF. Similar content being viewed by others

References

K. Nouza, R. Kinsky, and D. G. Dimitrov, Folia Biol (Praha) 38: 170 (1992). A. Bukovsky and J. Presl, Med. Hypoth. 7: 1 (1981). N. J. Alexander and D. J. Anderson, Fertil. Steril. 47: 192 (1987). J. A. Hill, H. M. P. Faris, I. Schiff, and D. J. Anderson, Fertil Steril 50: 216 (1988). J. A. Hill, Colloque INSERM 212: 269 (1991). M. Petrovská, R. Sedlák, K. Nouza, J. Presl, and R. Kinsky, Am. J. Reprod. Immunol 28: 77 (1992). D. G. Dimitrov, R. Sedlák, K. Nouza, and R. Kinsky, J. Immunol Methods 154: 147 (1992). Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 1995 Springer Science+Business Media New York About this chapter Cite this chapter Nouza, K. et al. (1995). Immunocytes and Cell-Mediated Immunity in the Pathology of Reproduction. In: Mestecky, J., Russell, M.W., Jackson, S., Michalek, S.M., Tlaskalová-Hogenová, H., Šterzl, J. (eds) Advances in Mucosal Immunology. Advances in Experimental Medicine and Biology, vol 371. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1941-6_77 Download citation DOI: https://doi.org/10.1007/978-1-4615-1941-6_77 Publisher Name: Springer, Boston, MA Print ISBN: 978-1-4613-5796-4 Online ISBN: 978-1-4615-1941-6 eBook Packages: Springer Book Archive

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Autoantibodies Corpus Luteum Cytokines Endometriosis Immunity, Cellular Infertility, Female Infertility, Male Isoantibodies Spermatozoa Abortion, Habitual Abortion, Habitual Adult Ascitic Fluid Ascitic Fluid Autoantibodies Corpus Luteum Cytokines Endometriosis Female

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