The possible molybdenum involvement on right ventricular performance in LVAD patients – initial study

The possible molybdenum involvement on right ventricular performance in LVAD patients – initial study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article The possible molybdenum involvement on right ventricular performance in LVAD patients – initial study Tomasz Urbanowicz, Filip Wojewódzki, Małgorzata Tomaszewska, Małgorzata Ładzińska, and 7 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6523437/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted 14 You are reading this latest preprint version Abstract Background: The left ventricular device (LVAD) implantation has evolved as a standard of care for heart failure (HF) patients. Optimal management is paramount, including additional strategies to achieve durable results. The study aimed to compare the right ventricular characteristics after LVAD implantation with trace element serum accumulation and to estimate the potential impact of specific trace elements on right ventricular performance. Method: There were 25 male patients in median (Q1 – Q3) age of 56 (51 – 62) years treated with left ventricular assist device implantation (HM3, Abbott Corp. USA) due to end-stage heart failure. Results: Patients presented with NYHA status I (12 (48%) patients) and II (13 (52%) patients) on the control follow-up check-ups, the median (Q1 – Q3) time of 421 (296 - 1277) days. The right ventricular diameter dilatation was observed in 7 (28%) patients and regression in 8 (32%) more patients. Among trace elements analysis, the significant differences related to molybdenum concentration between patients characterized by RV dilatation (1.76 (1.73 – 2.00) vs no-RV deterioration 2.61 (2.19 – 2.95) ug/l) was noted (p=0.030). While comparing the patients characterized by RV diameter regression (3.23 (2.92 – 3.61) ug/l vs control group (2.00 (1.73 – 2.19) ug/l), the significant difference related to molybdenum concentration was noticed (p=0.018). Conclusions: The low serum molybdenum concentration can be linked to adverse right ventricular performance after LVAD implantation, contrary to higher molybdenum values related to right ventricular regression. Biological sciences/Biochemistry Biological sciences/Chemical biology Health sciences/Cardiology LVAD MCS heart failure trace elements molybdenum Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Under Review Version 1 posted Reviews received at journal 05 Apr, 2026 Reviews received at journal 02 Apr, 2026 Reviews received at journal 29 Mar, 2026 Reviewers agreed at journal 26 Mar, 2026 Reviewers agreed at journal 26 Mar, 2026 Reviewers agreed at journal 21 Mar, 2026 Reviewers agreed at journal 20 Mar, 2026 Reviews received at journal 24 Feb, 2026 Reviewers agreed at journal 22 Feb, 2026 Reviewers invited by journal 20 Feb, 2026 Editor assigned by journal 30 Jul, 2025 Editor invited by journal 29 Apr, 2025 Submission checks completed at journal 28 Apr, 2025 First submitted to journal 24 Apr, 2025 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6523437","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":595419170,"identity":"22be9107-0bb0-451e-8360-d973b6027360","order_by":0,"name":"Tomasz 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elements, molybdenum","lastPublishedDoi":"10.21203/rs.3.rs-6523437/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6523437/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground: \u003c/strong\u003eThe left ventricular device (LVAD) implantation has evolved as a standard of care for heart failure (HF) patients. Optimal management is paramount, including additional strategies to achieve durable results. The study aimed to compare the right ventricular characteristics after LVAD implantation with trace element serum accumulation and to estimate the potential impact of specific trace elements on right ventricular performance.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethod:\u003c/strong\u003e There were 25 male patients in median (Q1 – Q3) age of 56 (51 – 62) years treated with left ventricular assist device implantation (HM3, Abbott Corp. USA) due to end-stage heart failure.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults:\u003c/strong\u003e Patients presented with NYHA status I (12 (48%) patients) and II (13 (52%) patients) on the control follow-up check-ups, the median (Q1 – Q3) time of 421 (296 - 1277) days. The right ventricular diameter dilatation was observed in 7 (28%) patients and regression in 8 (32%) more patients. 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While comparing the patients characterized by RV diameter regression (3.23 (2.92 – 3.61) ug/l vs control group (2.00 (1.73 – 2.19) ug/l), the significant difference related to molybdenum concentration was noticed (p=0.018).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions: \u003c/strong\u003eThe low serum molybdenum concentration can be linked to adverse right ventricular performance after LVAD implantation, contrary to higher molybdenum values related to right ventricular regression.\u003c/p\u003e","manuscriptTitle":"The possible molybdenum involvement on right ventricular performance in LVAD patients – initial study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-02-24 12:35:46","doi":"10.21203/rs.3.rs-6523437/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"editorInvitedReview","content":"","date":"2026-04-05T18:14:05+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-04-02T18:57:32+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-03-29T22:43:28+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"15664778485090970793020919232078131910","date":"2026-03-26T22:25:33+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"51597527344004135220777417903272094180","date":"2026-03-26T21:12:39+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"270980176029190100281474243383608727805","date":"2026-03-21T12:34:03+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"9237754741026084424096231680191027722","date":"2026-03-20T20:07:15+00:00","index":"hide","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2026-02-25T03:43:28+00:00","index":"hide","fulltext":""},{"type":"reviewerAgreed","content":"182289133427958218069541618094784746988","date":"2026-02-22T21:56:00+00:00","index":"hide","fulltext":""},{"type":"reviewersInvited","content":"","date":"2026-02-20T10:55:45+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2025-07-30T14:02:50+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2025-04-29T05:06:50+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2025-04-28T07:49:50+00:00","index":"","fulltext":""},{"type":"submitted","content":"Scientific Reports","date":"2025-04-24T19:49:24+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"scientific-reports","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scirep","sideBox":"Learn more about [Scientific Reports](http://www.nature.com/srep/)","snPcode":"","submissionUrl":"","title":"Scientific Reports","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"stoa","reportingPortfolio":"Scientific Reports","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"69b14b24-d18d-4233-aea0-ae6cbc828d80","owner":[],"postedDate":"February 24th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[{"id":63353483,"name":"Biological sciences/Biochemistry"},{"id":63353484,"name":"Biological sciences/Chemical biology"},{"id":63353485,"name":"Health sciences/Cardiology"}],"tags":[],"updatedAt":"2026-02-24T12:35:46+00:00","versionOfRecord":[],"versionCreatedAt":"2026-02-24 12:35:46","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6523437","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6523437","identity":"rs-6523437","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}