A Trustworthy Mechanochemical Route to Isocyanides: The Handyman of Chemistry

Isocyanides are hardly-to-produce, dramatically sensitive to purification processes and complex to handle as synthetic tools. Notwithstanding this, they represent one of the most refined and valuable compounds for accessing sophisticated and elegant synthetic routes. A unique interest has always been addressed to their production, though their synthetic pathways usually involve employing strong conditions and toxic reagents. The current paper intends to provide a conceptually innovative synthetic protocol designed for mechanochemical isocyanide preparation, simultaneously lowering the related reagents' toxicity and improving their purification in a straightforward procedure.