The Relationship between Endometriosis and TNF-β G252A Gene

Objective: To investigate the role of TNF-β G252 A gene in pathogenesis of endometriosis( Ems). Methods: Eighty Ems patients diagnosed by laparoscopy and histopathologic examination served as Ems group and 80 healthy women served as control group. PCR-RFLP was used to detect gene frequency of TNF-β G252 A gene,and ELISA was applied to check the serum content of TNF-β.The relationship of Ems and TNF-β G252 A gene was analyzed. Result: The serum level of TNF-β in Ems group was higher than that in control group( P 0. 05),and the serum level of TNF-β in Ems group was positively associated with EMT period. A/A and G/A genotypic frequencies in Ems group were significantly higher than those in control group. The risk of Ems of A/A genotype was 3. 5 times of G/G genotype. Conclusions: The serum level of TNF-β in Ems patients is positively associated with EMT period,and A/A genotype is the risk genotype of Ems.