Reliable and rapid smooth extubation after Ketofol for induction of general anesthesia in Laparoscopic Drilling of polycystic ovary: A randomized controlled trial.

Background: The impact of ketofol on the hemodynamics and the airway response during the induction of general anesthesia has been studied before. However, its effect on the smoothness of extubation has not been studied before. Thus, we aimed to assess the effect of ketofol on the smoothness of extubation and compare it with propofol for the induction of general anesthesia. Methods: : This double-blind, randomized, and controlled study was conducted on 106 class I and II female patients with the “American Society of Anesthesiologists Physical Status (ASA PS),” aged 18–40 years and scheduled for laparoscopic drilling for polycystic ovary disease under general anesthesia. The patients were assigned to one of two groups of (53) patients each; group KP = ketofol and group P = propofol. Results: There was a good sedation score during suction and extubation in the ketofol group. Airway response and smoothness of extubation were better in the ketofol than in the propofol group. Conclusion: Ketofol as an induction anesthetic agent was effective in attenuating the airway response during extubation more than only propofol. Trial registration: This trial was retrospectively registered at the Clinical Trial.gov with the Identification Number: NCT04365686.