Relationship between chemotactic cytokine ENA-78 and endometriosis

Objective:To detect the expression levels of chemotactic cytokine epithelial neutrophil-activating peptide-78 (ENA-78) in peritoneal fluid and ectopic tissues of patients with endometriosis,explore the role of ENA-78 in pathogenesis of endometriosis.Methods:The levels of ENA-78 in peritoneal fluid of patients with endometriosis (study group) and patients with hysteromyoma (control group) were detected by enzyme-linked immunosorbent assay (ELISA).The expression levels of ENA-78 protein in ectopic and eutopic tissues were measured by immunohistochemical technique.Results:①The level of ENA-78 in peritoneal fluid in study group was significantly higher than that in control group (P0.05),increasing with the aggravation of disease (P0.05).②ENA-78 located in cytoplasm of ectopic glandular cells,stromal cells and macrophages,expression levels increased with the aggravation of disease (P0.05),there was no significant difference in ENA-78 expression between different menstrual cycles (P0.05).③The expression of ENA-78 in eutopic tissues of study group was higher than that of control group (P0.05).Conclusion:ENA-78 is an important inflammatory media,which can activate the activity of inflammatory cells,promote the angiogenesis of ectopic endometrial tissues and play an important role in the occurrence and development of endometriosis,increase with the progression of endometriosis.At the same time,it is a biological indicator of invasion of endometriosis.