Nociplastic Pain in Endometriosis: A Scoping Review

Gentles, Avonae, Goodwin, Emma, Bedaiwy, Yomna, Marshall, Nisha, Yong, Paul J.
2025 · doi:10.14288/1.0447680 · W6961140041
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⚙ AI-generated summary by qwen3.7-flash, 2026-09-02 ⓘ

This scoping review identifies the diverse array of tools, including patient-reported questionnaires and quantitative sensory testing, currently used to detect central sensitization and nociplastic pain in endometriosis patients.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-15 · read from full text ⓘ

This scoping review investigated what tools have been used to characterize central sensitization (CS) and nociplastic pain in endometriosis-related chronic pelvic pain, focusing on identifying methods that assess nociplastic mechanisms. Using PRISMA-P, the authors searched MEDLINE, Embase, Scopus, and PsychINFO (23 April 2024) for publications mentioning assessment tools for nociplastic pain or CS in endometriosis patients, extracting demographics, assessment types, and specific tools. From 379 citations, 30 papers met inclusion criteria, with fourteen relying solely on patient-reported questionnaires, six using quantitative sensory testing (QST), two using clinical assessments, and eight using combinations of approaches; a key caveat is the lack of standardized, validated methods across studies. This paper is centrally about endometriosis — it reviews available tools for detecting nociplastic pain/central sensitization in endometriosis-related chronic pelvic pain.

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Abstract

Endometriosis is an inflammatory chronic condition associated with nociceptive, neuropathic, and nociplastic pain. Central sensitization (CS) is the primary nociplastic pain mechanism. However, there are currently no standardized methods for detecting CS or nociplastic pain. This review aims to identify available tools for characterizing CS/nociplastic pain in endometriosis-related chronic pelvic pain. Following the PRISMA-P protocol, MEDLINE, Embase, Scopus, and PsychINFO databases were searched on 23 April 2024, for the terms “endometriosis”, “central sensitization”, “nociplastic pain”, “widespread pain”, and “assessment tools”. Publications were selected if they mentioned tool(s) for detecting nociplastic pain or CS in endometriosis patients. Information was extracted on study demographics, assessment types, and the tools used for detection. Of the 379 citations retrieved, 30 papers met the inclusion criteria. When working to identify CS and nociplastic pain, fourteen studies exclusively used patient-reported questionnaires, six used quantitative sensory testing (QST), two used clinical assessments, and eight used multiple approaches combining patient-reported questionnaires and clinical assessment. This review illustrates the diversity of tools currently used to identify CS and nociplastic pain in endometriosis patients. Further research is needed to evaluate their validity and to standardize methods in order to improve the accuracy of nociplastic pain identification and guide treatment.
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- Library Home / - Search Collections / - Open Collections / - Browse Collections / - UBC Faculty Research and Publications / - Nociplastic Pain in Endometriosis: A Scoping Review Open Collections UBC Faculty Research and Publications Nociplastic Pain in Endometriosis: A Scoping Review Gentles, Avonae; Goodwin, Emma; Bedaiwy, Yomna; Marshall, Nisha; Yong, Paul J. Abstract Endometriosis is an inflammatory chronic condition associated with nociceptive, neuropathic, and nociplastic pain. Central sensitization (CS) is the primary nociplastic pain mechanism. However, there are currently no standardized methods for detecting CS or nociplastic pain. This review aims to identify available tools for characterizing CS/nociplastic pain in endometriosis-related chronic pelvic pain. Following the PRISMA-P protocol, MEDLINE, Embase, Scopus, and PsychINFO databases were searched on 23 April 2024, for the terms “endometriosis”, “central sensitization”, “nociplastic pain”, “widespread pain”, and “assessment tools”. Publications were selected if they mentioned tool(s) for detecting nociplastic pain or CS in endometriosis patients. Information was extracted on study demographics, assessment types, and the tools used for detection. Of the 379 citations retrieved, 30 papers met the inclusion criteria. When working to identify CS and nociplastic pain, fourteen studies exclusively used patient-reported questionnaires, six used quantitative sensory testing (QST), two used clinical assessments, and eight used multiple approaches combining patient-reported questionnaires and clinical assessment. This review illustrates the diversity of tools currently used to identify CS and nociplastic pain in endometriosis patients. Further research is needed to evaluate their validity and to standardize methods in order to improve the accuracy of nociplastic pain identification and guide treatment. Item Metadata | Title | Nociplastic Pain in Endometriosis: A Scoping Review | | Creator | | | Contributor | | | Publisher | Multidisciplinary Digital Publishing Institute | | Date Issued | 2024-12-10 | | Description | Endometriosis is an inflammatory chronic condition associated with nociceptive, neuropathic, and nociplastic pain. Central sensitization (CS) is the primary nociplastic pain mechanism. However, there are currently no standardized methods for detecting CS or nociplastic pain. This review aims to identify available tools for characterizing CS/nociplastic pain in endometriosis-related chronic pelvic pain. Following the PRISMA-P protocol, MEDLINE, Embase, Scopus, and PsychINFO databases were searched on 23 April 2024, for the terms “endometriosis”, “central sensitization”, “nociplastic pain”, “widespread pain”, and “assessment tools”. Publications were selected if they mentioned tool(s) for detecting nociplastic pain or CS in endometriosis patients. Information was extracted on study demographics, assessment types, and the tools used for detection. Of the 379 citations retrieved, 30 papers met the inclusion criteria. When working to identify CS and nociplastic pain, fourteen studies exclusively used patient-reported questionnaires, six used quantitative sensory testing (QST), two used clinical assessments, and eight used multiple approaches combining patient-reported questionnaires and clinical assessment. This review illustrates the diversity of tools currently used to identify CS and nociplastic pain in endometriosis patients. Further research is needed to evaluate their validity and to standardize methods in order to improve the accuracy of nociplastic pain identification and guide treatment. | | Subject | | | Genre | | | Type | | | Language | eng | | Date Available | 2025-01-06 | | Provider | Vancouver : University of British Columbia Library | | Rights | CC BY 4.0 | | DOI | 10.14288/1.0447680 | | URI | | | Affiliation | | | Citation | Journal of Clinical Medicine 13 (24): 7521 (2024) | | Publisher DOI | 10.3390/jcm13247521 | | Peer Review Status | Reviewed | | Scholarly Level | Faculty; Researcher | | Rights URI | | | Aggregated Source Repository | DSpace | Item Media Item Citations and Data Rights CC BY 4.0

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