MicroRNA-183-5p Promote Hepatocellular Carcinoma Proliferation Via Accelerating Pyroptosis By Targeting FoxO1

Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer worldwide, causing 700,000 deaths annually. Despite decades of extensive research of HCC, the prognosis of HCC remains unsatisfactory, mainly due to lack of reliable sensitive biomarkers. Therefore, it is fundamentally important to identify novel biomarkers for early diagnosis of HCC, as well as explore the underlying mechanisms of HCC progression. Pyroptosis, a highly inflammatory form of lytic programmed cell death, is attracting more attention in HCC. microRNAs are involved in the regulation of pyroptosis. miR-183-5p, an oncogene, is up-regulated in HCC, but it is unclear the relationship between miR-183-5p and pyroptosis in HCC, which was investigated in vitro. Our data demonstrated that miR-183-5p promoted proliferation of HCC, accompanied with upregulating pyroptosis related molecules, as well as IL-1β/IL-18.