A Facile and Rapid Synthetic Method for Indole-Chalcone Hybrids

Indole-chalcone hybrids are a large group of compounds known for their excellent biological properties against diverse pathogens. The current research describes a rapid synthetic pathway for the synthesis of ten (10) indole-chalcone hybrids 3(a-j), from 1-Boc-3-formylindole (1) and acetophenone derivatives (2), in a one-pot approach. The Boc was deprotected during the reaction and occurred automatically at the end of the reaction. 1H-NMR, 13C-NMR, and MS were used to elucidate the structures of the compounds. Contrary to previous methods for the synthesis of indole-chalcone hybrids, this novel synthetic method, which involves using a Boc-protected indole via microwave-assisted synthesis, is advantageous because it is a one-pot approach making it facile, and rapid.