Effects of small-molecule antagonists of the Tcf/β-catenin complex (PKF 115-584 and CGP049090) on stromal cell-mediated collagen gel contraction.

A–F: Collagen gel contraction at 0, 4, 8, 12, and 24 h in matched endometrial and endometriotic stromal cells from the same patient (A), *: p<.05: EES:deep endometriosis versus EES: ovarian endometriosis, endometrial stromal cells of patients with and without endometriosis (B), *: p<.05: versus EuEs: patients with endometriosis, treated and vehicle-treated endometrial stromal cells of patients with (C), *: p<.05: versus treated EuEs, and without endometriosis (D), *: p<.05: versus treated EuEs, treated and vehicle-treated endometriotic stromal cells (E, F), *: p<.05: versus treated EES, and G, H: Representative photomicrographs of contracted gels taken at 24 h in endometriotic stromal cells with and without treatment.\nNumerical values are presented as the mean + SEM.\nEES: endometriotic stromal cells; EuES: endometrial stromal cells.\nEndo (-): endometrium of patients without endometriosis.\nEndo (+): Endometrium of patients with endometriosis.\nEuES: ovarian endometriosis (n=10); EES: ovarian endometriosis (n=10).\nEuES: deep endometriosis (n=10); EES: deep endometriosis (n=10).\nEuES: patients with endometriosis (n=20); EuES: patients without endometriosis (n=10).