Adverse drug reactions, particularly liver disorders, drive prolonged interruptions in anti-tuberculosis treatment: a retrospective cohort study

Adverse drug reactions, particularly liver disorders, drive prolonged interruptions in anti-tuberculosis treatment: a retrospective cohort study | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL British Journal of Clinical Pharmacology This is a preprint and has not been peer reviewed. Data may be preliminary. 3 May 2025 V1 Latest version Share on Adverse drug reactions, particularly liver disorders, drive prolonged interruptions in anti-tuberculosis treatment: a retrospective cohort study Authors : Eleanor Dixon 0000-0001-9697-0068 , Evita Biraua , Edvards Brencsēns , Vitālijs Pašuks 0009-0009-2928-0839 , Vija Riekstina , Anete Šperberga , Marisa Muckian , James Dear 0000-0002-8630-8625 , Liga Kuksa , Derek Sloan , and Helen Stagg [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.174625205.58973464/v1 379 views 234 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Aim: Adverse drug reactions (ADRs) are a key driver of missed doses of anti-tuberculosis (TB) therapy. We aimed to determine the relative burden of ADR-driven missed doses, the missed dose patterns associated with ADRs, and the association between specific ADRs and missed doses. Methods: In this retrospective cohort study, adults (≥18 years) who began the standard six-month drug-sensitive anti-TB regimen in an outpatient facility in Riga, Latvia (May 2015–September 2022) and missed at least one dose of treatment were included. Data were collected from medical records and observed therapy records. Missed doses were subdivided into early discontinuation or sporadically missed. Descriptive analyses and lasagne plots were used Results: Across 174 patients, 31.0% (54) missed doses due to ADRs. 4,217/31,320 (13.5%) of doses were missed- 20.9% (880/4,217) were due to ADRs. 18/174 (10.3%) patients discontinued treatment early, 2/18 (11.1%) due to ADRs. Doses missed due to ADRs caused longer yet less frequent periods of sporadic missed doses: 56.4% (479/849) of sporadic missed doses were one day in length versus only 9.1% (7/77) for ADR-related ones. Hepatobiliary disorders were the leading ADR group causing missed doses. Metabolism and nutrition and hepatobiliary ADRs caused the longest median durations of missed doses. Conclusion: Our study underscores the importance of ADRs as a cause of missed doses of treatment, particularly hepatobiliary disorders. Regimens that are less prone to ADRs and strong healthcare system support structures for patients with ADRs are required to minimise missed doses, reducing unfavourable outcomes. Supplementary Material File (latvia paper_bjcp.docx) Download 1.61 MB Information & Authors Information Version history V1 Version 1 03 May 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Collection British Journal of Clinical Pharmacology Keywords adherence adverse drug reactions antibiotics clinical pharmacology infectious diseases Authors Affiliations Eleanor Dixon 0000-0001-9697-0068 The University of Edinburgh View all articles by this author Evita Biraua Riga East University Hospital View all articles by this author Edvards Brencsēns Riga East University Hospital View all articles by this author Vitālijs Pašuks 0009-0009-2928-0839 Riga East University Hospital View all articles by this author Vija Riekstina Riga East University Hospital View all articles by this author Anete Šperberga Riga East University Hospital View all articles by this author Marisa Muckian London School of Hygiene & Tropical Medicine View all articles by this author James Dear 0000-0002-8630-8625 The University of Edinburgh View all articles by this author Liga Kuksa Riga East University Hospital View all articles by this author Derek Sloan University of St Andrews View all articles by this author Helen Stagg [email protected] London School of Hygiene & Tropical Medicine View all articles by this author Metrics & Citations Metrics Article Usage 379 views 234 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Eleanor Dixon, Evita Biraua, Edvards Brencsēns, et al. Adverse drug reactions, particularly liver disorders, drive prolonged interruptions in anti-tuberculosis treatment: a retrospective cohort study. Authorea . 03 May 2025. DOI: https://doi.org/10.22541/au.174625205.58973464/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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