Association between serum uric acid and fasting plasma glucose level in non-diabetic, pre-diabetic and diabetic adults: a population-based study in China

Objective: This study aimed to examine the relationship between serum uric acid (SUA) and fasting blood glucose (FBG) levels in a general population from Northwest China. Methods: : The current study used data from a cross-sectional survey conducted in Ningxia Hui Autonomous Region, which investigated the prevalence and risk factors of cardiovascular disease. All subjects underwent SUA and FPG test. Generalized additive model and two-piece wise linear regression models were applied to explore the relationships between SUA and FPG level. Triglyceride-glucose (TyG) was further taken as the index of insulin resistance, and its mediating effects on the association between SUA and FPG level was analyzed. Results: : A total of 10 217 individuals aged 18 and over were included in the current analysis. Generalized additive models verified the inverted U-shaped association between SUA and FPG level and the inflection points of FPG levels in the curves were 6.5mmol/L in male and 8.8mmol/L in female respectively. TyG is an intermediate variable in the relationship between SUA and elevated FPG level, the mediating effect of which are 12.82% ( P <0.001) and 34.02% ( P <0.001) in male and female respectively. Conclusions: : Inverted U-shaped associations between FPG and SUA levels were observed in both genders. The threshold of FPG level was generally lower in male than in female. The association is partly mediated through insulin insistence.