Predictive Value and Clinical Correlation of Baseline FeNO Levels for Balloon Pulmonary Angioplasty Efficacy in Patients with Inoperable chronic thromboembolic pulmonary hypertension

Predictive Value and Clinical Correlation of Baseline FeNO Levels for Balloon Pulmonary Angioplasty Efficacy in Patients with Inoperable chronic thromboembolic pulmonary hypertension | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Predictive Value and Clinical Correlation of Baseline FeNO Levels for Balloon Pulmonary Angioplasty Efficacy in Patients with Inoperable chronic thromboembolic pulmonary hypertension jianhua xu, Mian He, Xingxing Sun, Tianran Zhou, Hanqing Zhu, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8420176/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Balloon pulmonary angioplasty (BPA) has been confirmed to improve ventilatory efficiency and pulmonary gas exchange in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH), yet the underlying mechanisms driving these improvements remain poorly elucidated. Nitric oxide (NO), as a key endothelium-derived vasodilator, plays a critical role in regulating pulmonary vascular tone and endothelial function. Against this backdrop, the present study aimed to investigate the dynamic changes in fractional exhaled nitric oxide (FeNO) levels following BPA and clarify its correlation with a panel of clinical and functional parameters in this patient population. Methods A prospective cohort of 57 patients diagnosed with inoperable CTEPH was recruited from Shanghai Pulmonary Hospital Affiliated to Tongji University. Comprehensive clinical assessments, including measurements of FeNO, N-terminal pro-brain natriuretic peptide (NT-proBNP), pulmonary function tests (PFT), transthoracic echocardiography (TTE), cardiopulmonary exercise testing (CPET), and right heart catheterization (RHC), were conducted both before BPA treatment and after the completion of the intervention course. Results Patients were stratified into two subgroups based on baseline FeNO levels: FeNO < 25 ppb (n = 46) and FeNO ≥ 25 ppb (n = 11). Key findings were as follows: 1. FeNO levels increased significantly in the FeNO < 25 ppb group after BPA (P < 0.001), whereas no statistically significant change was observed in the FeNO ≥ 25 ppb group (P = 0.110). 2. In the FeNO < 25 ppb group, notable improvements were achieved in pulmonary function, cardiac structure and function, hemodynamic indices, and cardiopulmonary exercise capacity post-BPA; in contrast, the FeNO ≥ 25 ppb group exhibited improvements in cardiac function, hemodynamics, and cardiopulmonary exercise capacity, but no significant changes in pulmonary function parameters. 3. Correlation analysis revealed that baseline FeNO levels in the FeNO < 25 ppb group were negatively correlated with post-treatment changes in diffusing capacity of the lung for carbon monoxide (DLCO) and mean pulmonary artery pressure (mPAP), and positively correlated with baseline left ventricular end-systolic diameter (LVES); for the FeNO ≥ 25 ppb group, baseline FeNO levels were negatively correlated with baseline DLCO values. 4. No significant differences in baseline pulmonary function and cardiac function were detected between the two subgroups; however, the FeNO < 25 ppb group presented with higher baseline mPAP, pulmonary vascular resistance (PVR), and VE/VCO2 slope (SLOPE), as well as lower baseline oxygen uptake efficiency slope (OUES). Moreover, the magnitude of improvements in LVED, LVES, and mPAP was more pronounced in the FeNO < 25 ppb group. Conclusion FeNO levels can serve as a reliable predictive biomarker for treatment response to BPA in CTEPH patients. Those with lower baseline FeNO levels tend to be more suitable candidates for BPA and achieve more comprehensive clinical benefits, while patients with higher FeNO levels may require adjunctive therapeutic strategies to optimize their treatment outcomes. FeNO CTEPH BPA Clinical correlation Figures Figure 1 Figure 2 Figure 3 Introduction CTEPH belongs to the fourth major classification of pulmonary hypertension (PH)[ 1 ]. It is a debilitating condition marked by the obstruction of pulmonary vessels due to thrombotic occlusion, leading to progressive stenosis or occlusion, a surge in pulmonary vascular resistance, and elevated pulmonary artery pressure. Ultimately, this cascade of events culminates in right-sided heart failure[ 2 ]. While the exact incidence of CTEPH remains elusive, it is approximated that approximately 3% of individuals who have experienced an acute pulmonary embolism will develop CTEPH. In the absence of timely intervention, the prognosis for CTEPH patients is grim, with their survival prospects intimately tied to the severity of the hemodynamic manifestations of PH[ 3 , 4 ]. CTEPH, though potentially curable through pulmonary endarterectomy (PEA), has demonstrated remarkable post-operative survival rates and functional improvements. However, it is noteworthy that over half of CTEPH patients are either ineligible for surgery or experience persistent or recurrent PH following PEA[ 5 , 6 ]. For these inoperable patients and those with residual symptomatic PH post-PEA, medical therapy has emerged as the current gold standard of care[ 7 ]. Despite the availability of effective medical treatments, a substantial proportion of inoperable CTEPH patients continue to suffer from persistent symptoms and limited exercise tolerance. Fortunately, in recent years, BPA has emerged as a promising therapeutic alternative for this challenging patient population. BPA offers a minimally invasive approach to improving pulmonary hemodynamics and alleviating symptoms by dilating obstructed pulmonary vessels and restoring blood flow to previously lung regions. By precisely targeting the characteristic vascular obstructions in CTEPH, BPA holds the potential to significantly enhance exercise tolerance and overall quality of life for these patients[ 8 ]. Several studies have documented the substantial improvement in hemodynamics and functional outcomes among CTEPH patients who have undergone BPA[ 9 , 10 ]. Furthermore, improvements in ventilatory efficiency and pulmonary gas exchange have also been reported following BPA procedures[ 11 ], However, the specific mechanisms by which it improves pulmonary circulation and cardio-pulmonary function have not been fully elucidated. FeNO serves as a valuable biomarker for assessing airway inflammation. It is generated through the catalytic action of nitric oxide synthase (NOS) and is present in various tissues including blood vessels, nerves, inflammatory cells, and the airway epithelium[ 12 ]. On the one hand, in the state of airway inflammation, inflammatory factors can induce upregulation of NOS activity, promoting the massive release of NO, which leads to elevated FeNO levels. Therefore, FeNO can reflect the degree of airway inflammation[ 13 ]. On the other hand, NO, as a core vasodilator secreted by pulmonary vascular endothelial cells, is a key molecule in regulating pulmonary vascular tone[ 14 ]. Its abnormal synthesis and release are closely related to pulmonary vascular remodeling.In the pathological process of CTEPH, pulmonary vascular endothelial injury and microcirculatory disorders caused by thrombus obstruction are core links in disease progression. Studies have shown that CTEPH patients have abnormal expression of endothelial nitric oxide synthase (eNOS), which is the main source of NO synthesis in the pulmonary circulation. Downregulation of eNOS leads to insufficient endogenous NO production, thereby exacerbating pulmonary vasoconstriction and remodeling, and promoting the progression of pulmonary hypertension[ 15 – 17 ]. Meanwhile, CTEPH patients not only have large vessel thrombotic obstruction but also commonly exhibit lesions in distal small vessels. This microcirculatory damage directly affects the efficiency of pulmonary gas exchange, and pulmonary carbon monoxide diffusion capacity (DLCO) is a core indicator for evaluating microcirculatory function[ 18 ]. Existing studies have found that FeNO levels are associated with pulmonary microcirculatory function; in patients with pulmonary hypertension complicated by interstitial lung disease, elevated FeNO can reflect microvascular dysfunction[ 19 ]. However, research on the specific association between FeNO and microcirculatory injury, endothelial dysfunction in CTEPH patients remains relatively scarce. Existing studies on the efficacy of BPA have primarily focused on hemodynamic improvement (such as reduced mean pulmonary arterial pressure and pulmonary vascular resistance)[ 20 ] and recovery of exercise function[ 21 ], without incorporating endothelial function and inflammatory markers like FeNO into the efficacy evaluation system. Furthermore, in other types of pulmonary arterial hypertension such as idiopathic pulmonary arterial hypertension (IPAH), FeNO has been confirmed to predict the efficacy of targeted drug therapy[ 22 ]. However, the pathogenic mechanisms of CTEPH (thrombotic obstruction + vascular remodeling) and IPAH (idiopathic vascular remodeling) are fundamentally different, and the predictive value of FeNO in CTEPH treatment and the effect of BPA on its levels remain unclear. Given the close association of FeNO with pulmonary vascular endothelial function and microcirculatory status, as well as the gap in mechanism research on BPA treatment for CTEPH, this study aims to analyze the changes in FeNO levels before and after BPA treatment in patients with non-surgical CTEPH, and their correlations with indicators such as lung function, hemodynamics, and cardiopulmonary exercise capacity. This will provide a theoretical basis for revealing the mechanism by which BPA improves pulmonary circulation function and optimizing individualized treatment strategies for CTEPH. Patients and Methods Ethical approval The study protocol was thoroughly reviewed and approved by the Ethics Committee of Shanghai Pulmonary Hospital. All methods, including echocardiography, measurement of brain natriuretic peptide (NT-proBNP), RHC, CPET, PFT, and FeNO measurements, were conducted in strict accordance with the applicable guidelines and regulations. All our participants have provided informed consent. Patients This study proactively enrolled 57 patients diagnosed with CTEPH, who underwent evaluation at Shanghai Pulmonary Hospital between May 2019 and June 2024. All patients referred for BPA. Eligibility criteria and techniques used to perform BPA were similar to those described elsewhere[23]. A comprehensive workup encompassed clinical assessment, RHC, echocardiography, CPET, and PFT. These evaluations were conducted initially at the baseline stage during the diagnosis of CTEPH and subsequently reassessed at least 2 sessions BPA. Each parameter was examined before first BPA and 6 months after last BPA. Patients whose PH-directed therapy underwent any alterations between the two workup periods were excluded from the analysis. Additionally, individuals with a pulmonary arterial wedge pressure (PAWP) exceeding 15 mmHg were also disqualified from the study. In addition, patients with concurrent chronic pulmonary diseases such as COPD and asthma are also excluded. PFT We conducted pulmonary function tests, using standard equipment (Masterscreen-PFT, Jaeger crop, Hoechberg, Germany) and following the guidelines recommended by the European Respiratory Society (ERS)[24]. The following parameters were determined: Forced Vital Capacity(FVC), FVC% predicted, Forced Expiratory Volume in one second(FEV1), FEV1% predicted, diffusing capacity for lung carbon monoxide(DLCO), DLCO% predicted, total lung capacity (TLC), TLC% predicted[25]. FeNO The FeNO levels were meticulously evaluated utilizing a state-of-the-art electrochemical breath analyzer sourced from Shangwo Medical Electronics in Wuxi, China. To eliminate any potential confounders arising from food or beverage consumption, patients were thoroughly instructed to abstain from any form of ingestion for a minimum period of two hours preceding the FeNO measurement. During the measurement process, patients were guided to maintain a consistent and even breathing pattern, encompassing at least two complete breath cycles. Importantly, they were instructed to exhale at a constant and controlled airflow rate of 50 mL/s for a duration of 10 seconds. To further enhance the robustness of the data, FeNO levels were measured in triplicate for each patient, under carefully maintained stable conditions. This repetitive measurement protocol was implemented to ensure that any variations between readings were minimal, with a strict criterion of no more than 10% difference among the measurements. RHC All patients diagnosed with CTEPH underwent a rigorous RHC procedure. During this procedure, a precision True Size Thermodilution Catheter (model 774 by Edward Lifesciences) was meticulously inserted via the left cubital vein. The comprehensive hemodynamic assessment encompassed several critical parameters, including Right Atrium Pressure (RAP), Right Ventricular Pressure (RVP), mPAP, and pulmonary artery wedge pressure (PAWP), Cardiac output (CO), Cardiac input (CI), PVR was precisely calculated using established formulas, specifically PVR = (mPAP – PAWP)/CO. TTE (transthoracic echocardiography) Transthoracic echocardiography, utilizing a commercially accessible system (Vivid 7 Dimension), was conducted at the commencement of the study and reiterated in the third month, ensuring consistency through the same physician's expertise. The primary metrics garnered from these scans encompassed the systolic pulmonary artery pressure (PAP systolic), the dimensions of the right atrium and right ventricle, alongside key left ventricular parameters such as the LVED, LVES, and the tricuspid annular plane systolic excursion (TAPSE). This comprehensive assessment allowed for a thorough evaluation of cardiac function and structure. BPA The BPA procedure and all materials are similar to this study(20)[26]. Pulmonary angiography was performed selectively in anterior-posterior and lateral (45 degree) projections after RHC to acquire overall view about the position and degree of filling defect in combination with previous ventilation/perfusion scintigraphy. The procedure of BPA was systematically executed via the right femoral vein by two highly skilled interventional cardiologists. To gain access, we delicately approached the femoral vein and inserted a 6 French (Fr) guiding sheath into the main pulmonary artery with precision. Subsequently, a versatile 6 Fr guiding catheter (such as Profit®, Multipurpose, or Judkins right and left 4.0 models, manufactured by Goodman in Nagoya, Aichi, Japan) was threaded through the peripheral guiding sheath and meticulously advanced towards the targeted vessels. Relying on meticulous selective pulmonary angiography, a 0.014-inch guide wire (specifically, the Athlete Bpahm® from Japan Lifeline in Tokyo, Japan) was skillfully navigated across the targeted lesion. Depending on the duration allowed for the procedure, each session entailed the treatment of 6 to 14 segmental or sub-segmental arteries, ensuring comprehensive care for the patient's condition. CPET CPET was performed utilizing an advanced, electromagnetically braked cycle ergometer (Master Screen CPX, Jaeger Crop, Hoechberg, Germany). The comprehensive protocol encompassed four distinct stages: an initial 3-minute rest period, followed by a 3-minute unloaded cycling phase, an incremental workload phase, and a final 5-minute recovery phase. A wide array of physiological parameters was meticulously recorded and calculated, including PeakLaod, PeakV'O2 (Oxygen uptake), PeakV'CO2 (Carbon dioxide output), PeakPETO2(Peak End-Tidal Oxygen Partial Pressure), PeakPETCO2(Peak End-Tidal Carbon Dioxide Partial Pressure), PeakVE/VCO2 (Ventilation/Carbon dioxide output), OUEP (Oxygen Uptake Efficiency Plateau), VE/VCO2 slope (SLOPE), OUES. Statistical analysis The statistical analyses were meticulously conducted utilizing the SPSS 22.0 and GraphPad Prism 5 software packages. The data were presented as either as mean±SD or frequency and median (interquartile range). To assess the normality of the data distributions, the rigorous Shapiro–Wilk test was employed. For the comparison of differences between two independent groups, an independent sample t-test was utilized. To evaluate changes in indexes before and after BPA treatment, a paired sample t-test was appropriately applied, capturing the intragroup variations. In cases where data failed to adhere to normal distribution, the Wilcoxon Signed-Rank Test was invoked. For normally distributed data, Pearson correlation coefficients were used, while for non-normal distributions, Spearman correlation coefficients were applied. Mann-Whitney U test for continuous variables, chi-square test for categorical variables. A p-value less than 0.05 was deemed statistically significant throughout the analysis. "Change" refers to (post-BPA FeNO) − (pre-BPA FeNO). Results Clinical characteristics in CTEPH Baseline characteristics of CTEPH patients stratified by FeNO levels are summarized in Table 1. No significant differences were observed between the FeNO<25 ppb (n=46) and FeNO≥25 ppb (n=11) groups in terms of sex distribution (15M/31F vs 3M/8F, p=0.737), age (median 62 vs 63 years, p=0.585), or BMI (median 23.85 vs 24.88 kg/m², p=0.293). Although WHO functional class distribution trended toward significance (p=0.147), with more patients in Class III–IV in the FeNO≥25 group (5/11 vs 30/46), this did not reach statistical threshold. Comorbid disease prevalence varied between groups, with hypertension (12 vs 4 cases) and pulmonary embolism (25 vs 5 cases) being most frequent. Notably, no patients in the FeNO≥25 group had diabetes mellitus (0/11). Pharmacotherapy patterns showed riociguat monotherapy as the most common regimen (29/46 vs 8/11), while combination therapies (e.g., macitentan-riociguat) were less frequently used. Statistical comparisons for comorbidities and medications were not performed due to small subgroup sizes. Table 1. Baselinely characteristics, comorbidities, and medication regimens in patients with CTEPH, stratified by FeNO levels (FeNO<25 ppb vs FeNO≥25 ppb). Factors FeNO<25(n=46) FeNO≥25(n=11) P值 Sex, M/F 15/31 3/8 0.737 Age, years 62(54.75,70) 63(55,73) 0.585 BMI, kg/m2 23.85(22.13,26.12) 24.88(23.50,26.78) 0.293 WHO functional class, n Class I, II/III, IV 16/30 6/5 0.147 Comorbid diseases Hypertension 12 4 Diabetes mellitus 3 0 deep vein thrombosis 7 5 coronary artery disease 3 2 pulmonary embolism 25 5 Medication Sildenafil+Macitentan 2 0 Riociguat 29 8 Ambrisentan+Riociguat 5 0 Macitentan+Riociguat 8 2 Bosentan+Riociguat 1 0 Ambrisentan+Sildenafil 1 1 The data are presented as frequency. BMI = body mass index; IQR = interquartile range; FeNO = fractional exhaled nitric oxide. Differences in lung function, hemodynamics and CPET after BPA treatment, stratified by FeNO levels In the FeNO <25 ppb cohort (n=46), BPA resulted in significant improvements across multiple domains: Biomarkers: Pulmonary Function: Both FVC(p=0.006) and FVC% predicted (p=0.006) improved significantly; Hemodynamics: mPAP and PVR demonstrated clinically meaningful reductions; Exercise Capacity: Enhanced performance was observed in multiple CPET parameters. Notably, FeNO levels increased post-BPA from 13.96±5.37 to 19.89±7.21 ppb (p<0.001) (Figure. 2A). NT-proBNP levels decreased markedly (p<0.001) (Figure. 2C), indicating reduced cardiac stress; The smaller FeNO ≥25 ppb cohort (n=11) exhibited distinct response patterns: Hemodynamic Benefits: Similar to the FeNO <25 group, significant reductions in PVR were achieved (7.78 [6.21,10.32] vs 3.37 [2.64,4.14] Wood units, p<0.001). Non-significant Changes: FeNO (p=0.110) (Figure. 2B), NT-proBNP (p=0.123) (Figure. 2D), and spirometric parameters showed no statistically significant improvements. OUEP improved significantly (+15.9%, p=0.012) despite unchanged peak exercise metrics, suggesting enhanced metabolic efficiency. Despite hemodynamic improvements, DLCO failed to improve significantly in either group post-BPA (FeNO <25: p=0.243; FeNO ≥25: p=0.374). This finding suggests that: residual small vessel disease may persist despite macrovascular recanalization, DLCO could serve as a marker for microvascular involvement in CTEPH(11). Combination therapies targeting both vascular beds may be warranted for comprehensive disease modification. Table 2. Comparative analysis of pre- and post-BPA parameters in patients with CTEPH, stratified by baseline FeNO levels. Factors Pre-BPA （ n=46 ） Post-BPA （ n=46 ） P 值 Pre-BPA （ n=11 ） Post-BPA （ n=11 ） P 值 FeNO<25 FeNO≥25 NT-proBNP, pg/mL 337.5(90.45,970.08) 89(43,185.03) <0.001 159.3(39,212.4) 75.6(51.2,137.9) 0.123 FeNO, ppb 13.96±5.37 19.89±8.20 <0.001 30(28,48) 29(13,39) 0.110 PFT FVC, L 2.57(2.33,3.05) 2.76(2.34,3.01) 0.006 2.89±0.80 2.93±0.89 0.527 FVC% predicted 88.08±10.70 91.50±10.88 0.006 91.84±11.47 93.37±9.00 0.539 FEV1, L 2.04(1.7,2.37) 2.05(1.8,2.35) 0.082 2.28±0,76 2.29±0.83 0.875 FEV1% predicted 84.2(77.8,92.4) 87.05(77.62,94.48) 0.061 89.09±13.67 89.75±12.22 0.813 FEV1/FVC% predicted 93.52±7.88 92.14±6.65 0.121 94.80±8.00 93.6±6.44 0.421 TLC, L 4.87(4.29,5.60) 4.79(4.28,5.42) 0.935 4.96±0.92 5.03±0.82 0.520 TLC% predicted 100.6(92.95,107.55) 100.75(92.48,107.88) 0.864 99.71±10.28 101.3±11.12 0.598 DLCO, mL/(mmHg·min) 16.77(13.77,20.03) 16.4(14.71,19.05) 0.243 15.08(12.86,16.2) 13.57(11.24,20.11) 0.374 DLCO% predicted 90.7(81.3,103.55) 91.4(84.3,99.8) 0.417 83.95±15.90 80.44±14.18 0.342 TTE PAP systolic, mm Hg 60.5(47.25,84) 40.5(33.75,49) <0.001 68.55±23.33 37.27±11.29 <0.001 Right atrium, cm 3.9(3.275,4.825) 3.5(3.1,3.9) 0.002 4.23±0.91 3.55±0.75 <0.001 Right ventricle, cm 4.07±0.76 3.51±0.62 <0.001 3.6(3.4,3.9) 3.2(2.8,3.6) 0.014 LVED, cm 2.3(1.95,2.625) 2.7(2.5,3.1) <0.001 2.41±0.58 2.54±0.53 0.645 LVES, cm 4.22±0.71 4.86±0.45 <0.001 4.46±0.64 4.59±0.70 0.585 TAPSE 1.9(1.6,2.15) 2.15(2,2.3) 0.004 2.01±0.36 2.05±0.29 0.666 RHC RAP, mmHg 2.5(2,5) 2.54±2.34 0.343 3(2,5) 4.55±2.98 0.474 RVP, mmHg 6(5,8.25) 5(4,7) 0.066 6.8±5.33 6.64±2.84 0.434 mPAP, mmHg 43.65±7.38 26.96±6.14 <0.001 36(28,48) 27.45±6.22 0.008 PAWP, mmHg 7(5,8) 8(6,10) 0.008 7.09±4.11 9.55±3.67 0.095 CO, L/min 4.71±1.17 5.72±1.08 <0.001 4.98±1.35 5.96±0.86 0.014 CI, L/(min×m 2 ) 2.8(2.29,3.19) 3.36(2.90,3.72) <0.001 2.89±0.66 3.47±0.45 0.016 PVR, wood 7.78(6.21,10.32) 3.37(2.64,4.14) <0.001 5.33(4.84,8.62) 3.03±0.95 0.003 CPET PeakLaod, watt 65.31±21.48 73.46±28.63 0.024 78.42±18.13 85.88±22.53 0.210 PeakV'O2, mL/min 843.11±214.37 967.39±317.60 0.019 969.92±293.66 1123.42±315.20 0.212 PeakV'CO2, mL/min 884.07±280.55 1027.02±385.71 0.050 1060.71±273.23 1176.83±410.81 0.458 PeakPETO2, mL/min 126.83±5.74 123.35±5.14 <0.001 125.35±5.07 121.03±7.00 0.105 PeakPETCO2, mL/min 23.35±5.31 26.82±4.43 <0.001 26.69±5.00 28.61±3.97 0.188 PeakVE/VCO2 50.61(44.41,60.00) 42.89(39.30,48.56) <0.001 43.63(37.23,50.04) 39.98±3.96 0.161 OUEP 24.50±3.99 27.59±3.75 <0.001 26.77±3.59 31.04±2.08 0.012 SLOPE 47.29(42.73,57.60) 39.46(35.90,44.09) <0.001 40.46±6.04 36.97±4.34 0.142 OUES 996.54±234.85 1143.63±282.93 0.002 1227.3±419.43 1260.88±399.31 0.820 The data are presented as mean ± SD, frequency and median (interquartile range). The data, which conformed to the orthographic distribution, underwent a paired-samples t-test to statistically evaluate any significant differences before and after BPA treatment. Wilcoxon signed-rank test was used for data that did not conform to normality of distributions. BNP=brain natriuretic peptide; FeNO=fractional exhaled nitric oxide; PFT= pulmonary function tests; FVC=forced vital capacity; FEV1= forced expiratory volume in 1 s; TLC= total lung capacity; DLCO=diffusing capacity of the lung for carbon monoxide; PAP= pulmonary artery pressure; RHC= Right heart catheterization; PVR=pulmonary vascular resistance; PAWP=pulmonary artery wedge pressure; CO=Cardiac output; RAP=Right atrial pressure; RVP=Right ventricular pressure; CI=Cardiac input; CPET=cardiopulmonary exercise testing; V'O2=Oxygen uptake; V'CO2=Carbon dioxide output; VE/VCO2=Ventilation/Carbon dioxide output; OUEP=Oxygen Uptake Efficiency Plateau; TTE= transthoracic echocardiography; LVED=Left ventricle end-diastolic diameter; LVES=Left ventricle end-systolic diameter; TAPSE= tricuspid annular plane systolic excursion; OUES=Oxygen Uptake Efficiency Slope. SLOPE=VE/VCO₂ Slope A comprehensive comparison of treatment responses to BPA in CETPH patients stratified by baseline FeNO levels. Baseline comparisons demonstrated significant between-group differences in key hemodynamic and cardiopulmonary parameters: Patients with FeNO<25 ppb exhibited higher Mpap (43.7±7.4 vs 36.0±5.2 mmHg, p=0.003), elevated PVR (7.78 [6.21,10.32] vs 5.33 [4.84,8.62] Wood units, p=0.012), steeper ventilatory efficiency slope (SLOPE: 47.29±11.00 vs 40.46±6.04, p=0.017), and lower oxygen uptake efficiency slope (OUES: 996.5±234.9 vs 1227.3±419.4, p=0.037) compared to the FeNO≥25 ppb group (Figure. 3A-H). No statistically significant differences were observed in other evaluated parameters, including lung function, TTE, or right ventricular function metrics (all p>0.05). Treatment responses analysis revealed distinct improvement patterns between subgroups: The FeNO <25 cohort demonstrated significantly greater improvements in FeNO (p=0.001), LVED (p=0.033), LVES (p=0.035), and mPAP (p=0.014) following intervention. These findings suggest that baseline FeNO levels may serve as a predictive biomarker for differential treatment response in CTEPH patients. The paradoxical association between lower baseline FeNO and superior hemodynamic improvement warrants further investigation into the underlying pathophysiological mechanisms linking nitric oxide metabolism to pulmonary vascular remodeling. Table 3. Comparative analysis of baseline characteristics and treatment response in CTEPH patients stratified by FeNO levels, showing both absolute values and changes after balloon pulmonary angioplasty (BPA). Factors FeNO<25 FeNO≥25 P 值 FeNO<25 FeNO≥25 P 值 baseline characteristics change NT-proBNP, pg/mL 337.5(90.45,970.08) 159.3(39,212.4) 0.079 -256.45(-859.58, -13.05) -93.90(-160.40,25.40) 0.163 FeNO, ppb 13.96±5.37 30(28,48) <0.001 6(-2.25,10.25) -10(-15,1) 0.001 PFT FVC, L 2.57(2.33,3.05) 2.89±0.80 0.649 0.08(-0.04,0.22) 0.07(-0.21,0.26) 0.483 FVC% predicted 88.08±10.70 91.84±11.47 0.391 3.41±8.01 1.53±8.01 0.489 FEV1, L 2.04(1.7,2.37) 2.28±0,76 0.537 0.06(-0.06,0.12) -0.01(-0.13,0.24) 0.723 FEV1% predicted 84.2(77.8,92.4) 89.09±13.67 0.262 1.35(-2.65,5.43) -1.7(-5.6,9.6) 0.564 FEV1/FVC% predicted 93.52±7.88 94.80±8.00 0.259 -1.38±1.58 -1.20±4.70 0.895 TLC, L 4.87(4.29,5.60) 4.96±0.92 0.926 0.01(-3.02,0.26) -0.01(-0.12,0.15) 0.927 TLC% predicted 100.6(92.95,107.55) 99.71±10.28 0.553 1.89±18.36 -0.20(-6,9.10) 0.864 DLCO, mL/(mmHg·min) 16.77(13.77,20.03) 15.08(12.86,16.2) 0.307 0.32(-1.09,1.78) -0.89(-2.63,0.99) 0.145 DLCO% predicted 90.7(81.3,103.55) 83.95±15.90 0.118 3.9±17.40 -3.51±11.67 0.229 TTE PAP systolic, mm Hg 60.5(47.25,84) 68.55±23.33 0.754 -23.98±27.74 -31.27±16.03 0.407 Right atrium, cm 3.9(3.275,4.825) 4.23±0.91 0.578 -0.55(-1.13,0.3) -0.7(-1.10,-0.30) 0.466 Right ventricle, cm 4.07±0.76 3.6(3.4,3.9) 0.538 -0.56±0.69 -0.7±0.83 0.561 LVED, cm 2.3(1.95,2.625) 2.41±0.58 0.291 0.5(0.1,0.83) -0.1(-0.4,0.5) 0.033 LVES, cm 4.22±0.71 4.46±0.64 0.260 0.64±0.70 0.13±0.75 0.035 TAPSE 1.9(1.6,2.15) 2.01±0.36 0.570 0.19±0.47 0.05±0.34 0.345 RHC RAP, mmHg 2.5(2,5) 3(2,5) 0.886 -0.57±3.31 0.91±4.04 0.209 RVP, mmHg 6(5,8.25) 6.8±5.33 0.706 -0.5(-4,1) -2(-3,4) 0.394 mPAP, mmHg 43.65±7.38 36(28,48) 0.047 -16.70±6.88 -10.72±7.64 0.014 PAWP, mmHg 7(5,8) 7.09±4.11 0.768 1(-1,4) 2(0,5) 0.583 CO, L/min 4.71±1.17 4.98±1.35 0.508 1.01±1.19 0.98±1.09 0.931 CI, L/(min×m 2 ) 2.8(2.29,3.19) 2.89±0.66 0.781 0.53(0.04,1.12) 0.43(0.33,1.1) 0.895 PVR, wood 7.78(6.21,10.32) 5.33(4.84,8.62) 0.022 -4.36(-6.34, -3.21) -2.9(-5.67, -1.36) 0.070 CPET PeakLaod, watt 65.31±21.48 78.42±18.13 0.117 8.16±18.35 7.46±15.29 0.921 PeakV'O2, mL/min 843.11±214.37 969.92±293.66 0.165 124.28±259.70 153.5±316.07 0.783 PeakV'CO2, mL/min 884.07±280.55 1060.71±273.23 0.113 142.94±310.17 116.13±417.97 0.837 PeakPETO2, mL/min 126.83±5.74 125.35±5.07 0.504 -3.48±4.27 -4.31±6.56 0.654 PeakPETCO2, mL/min 23.35±5.31 26.69±5.00 0.113 3.47±3.50 1.93±3.75 0.271 PeakVE/VCO2 50.61(44.41,60.00) 43.63(37.23,50.04) 0.078 -9.00±8.96 -8.48±18.71 0.906 OUEP 24.50±3.99 26.77±3.59 0.146 3.08±2.65 4.27±3.56 0.290 SLOPE 47.29(42.73,57.60) 40.46±6.04 0.017 -10.44±11.00 -3.49±5.97 0.093 OUES 996.54±234.85 1227.3±419.43 0.037 147.09±257.89 33.58±402.48 0.317 See Table 2 legend for expansion of abbreviations. A ssociations between FeNO levels and clinical parameters at baseline and after balloon pulmonary angioplasty BPA The relationship between FeNO levels and clinical parameters in patients with CTEPH was evaluated, stratified by FeNO thresholds, both at baseline and following BPA. These findings, presented in Table 4, reveal distinct patterns of association that may inform personalized treatment strategies and deepen our understanding of CTEPH pathophysiology. For the cardiac stress biomarker NT-proBNP, patients in the FeNO <25 ppb group exhibited a weak negative correlation at baseline (R = -0.110, p = 0.466) and a very weak positive correlation post-BPA (R = 0.029, p = 0.846). The FeNO ≥25 ppb group showed a no correlation at baseline (R = 0.284, p = 0.398) and post-BPA (R = -0.348, p = 0.295); Pulmonary function tests revealed notable differences in gas exchange efficiency as measured by DLCO. In the FeNO <25 ppb group, a no correlation was observed at baseline (R = -0.121, p = 0.429), while a moderate negative correlation post-BPA (R = -0.340, p = 0.021) indicated that higher baseline FeNO levels were associated with less improvement in DLCO following treatment. Conversely, the FeNO ≥25 ppb group demonstrated a strong negative correlation at baseline (R = -0.650, p = 0.030), linking elevated FeNO levels to compromised baseline gas exchange efficiency, possibly indicative of microvascular dysfunction. Post-BPA, a weak positive correlation (R = 0.279, p = 0.406) showed no significant relationship with treatment-induced DLCO changes. FVC showed no statistically significant correlations in either subgroup at baseline or post-BPA (all p > 0.05). Hemodynamic assessments revealed heterogeneous responses based on FeNO stratification. In the FeNO <25 ppb group, there is no correlation between FENO and baseline mPAP(R = 0.099, p = 0.513), a significant negative correlation was observed in post-BPA changes in mPAP (R = -0.293, p = 0.048) (Figure. 4A-B), demonstrating that patients with lower baseline FeNO levels experienced smaller mPAP reductions after BPA. In the FeNO≥25 ppb subgroup, FeNO shows no correlation with either baseline mPAP (R = -0.058, p = 0.866) or mPAP change (R = -0.090, p = 0.793) (Figure. 4C-D), suggesting differential hemodynamic responsiveness. LVES analysis in the FeNO <25 ppb group revealed a strong positive correlation at baseline (R = 0.354, p = 0.016), implying that higher FeNO levels were associated with adverse left ventricular remodeling, potentially reflecting increased afterload or biventricular dysfunction. Post-BPA, a negative correlation (R = -0.259, p = 0.083) indicated a trend toward LVES reduction in patients with lower baseline FeNO, though statistical significance was not reached. Exercise capacity parameters showed no significant correlations in either FeNO subgroup. Table 4. Correlation Analysis of Baseline and Post-Treatment Changes in Clinical Parameters Stratified by FeNO levels. Factors Baseline Change Baseline Change R P R P R P R P FeNO<25 FeNO≥25 NT-proBNP, pg/mL -0.110 0.466 0.029 0.846 0.284 0.398 -0.348 0.295 PFT FVC, L -0.169 0.262 -0.003 0.984 -0.183 0.590 0.245 0.467 FVC% predicted -0.132 0.382 0.030 0.842 -0.494 0.122 0.352 0.288 FEV1, L -0.256 0.085 -0.091 0.548 -0.183 0.590 0.048 0.888 FEV1% predicted -0.188 0.212 -0.135 0.371 -0.092 0.789 0.165 0.628 FEV1/FVC% predicted -0.287 0.054 -0.078 0.607 0.101 0.768 0.014 0.968 TLC, L -0.190 0.212 0.061 0.688 -0.055 0.873 -0.018 0.957 TLC% predicted -0.109 0.476 0.056 0.710 -0.348 0.295 -0.064 0.852 DLCO, mL/(mmHg·min) -0.121 0.429 -0.340 0.021 -0.650 0.030 0.279 0.406 DLCO% predicted 0.021 0.892 -0.337 0.022 -0.618 0.043 0.154 0.652 TTE PAP systolic, mm Hg -0.063 0.675 0.047 0.754 0.256 0.447 -0.311 0.352 Right atrium, cm -0.289 0.051 0.171 0.256 0.227 0.502 0.060 0.861 Right ventricle, cm -0.016 0.918 -0.095 0.530 0.512 0.108 -0.430 0.187 LVED, cm 0.269 0.071 -0.148 0.326 -0.078 0.820 0.115 0.737 LVES, cm 0.354 0.016 -0.259 0.083 -0.115 0.736 0.328 0.325 TAPSE -0.082 0.588 0.084 0.579 -0.345 0.299 -0.056 0.870 RHC RAP, mmHg 0.046 0.761 -0.231 0.122 0.280 0.404 -0.443 0.173 RVP, mmHg -0.193 0.200 -0.035 0.818 0.098 0.787 -0.396 0.228 mPAP, mmHg 0.099 0.513 -0.293 0.048 -0.058 0.866 -0.090 0.793 PAWP, mmHg 0.054 0.722 -0.143 0.342 0.127 0.710 -0.482 0.134 CO, L/min -0.136 0.366 0.170 0.257 -0.278 0.409 -0.243 0.472 CI, L/(min×m 2 ) -0.088 0.562 0.154 0.308 -0.431 0.185 -0.220 0.516 PVR, wood 0.109 0.471 -0.179 0.233 0.030 0.931 -0.027 0.936 CPET PeakLaod, watt -0.238 0.163 -0.243 0.153 -0.578 0.133 0.410 0.313 PeakV'O2, mL/min -0.218 0.202 -0.253 0.137 -0.458 0.254 0.169 0.690 PeakV'CO2, mL/min -0.228 0.181 -0.240 0.158 -0.506 0.201 0.253 0.545 PeakPETO2, mL/min -0.079 0.647 -0.095 0.580 0.084 0.843 -0.060 0.887 PeakPETCO2, mL/min 0.059 0.732 0.011 0.947 -0.337 0.414 0.277 0.506 PeakVE/VCO2 0.022 0.900 -0.003 0.986 0.446 0.268 -0.482 0.227 OUEP -0.093 0.591 -0.015 0.932 -0.446 0.268 -0.036 0.932 SLOPE -0.007 0.965 0.005 0.975 0.337 0.414 -0.217 0.606 OUES -0.141 0.411 -0.152 0.375 -0.253 0.545 0.229 0.586 Correlation coefficients were expressed as Pearson or Spearman correlation coefficients. See Table 2 legend for expansion of abbreviations. Discussion This study pioneers the systematic investigation of FeNO dynamics following BPA in patients with inoperable CTEPH, establishing baseline FeNO as a robust predictive biomarker for treatment response. By stratifying patients using a 25 ppb FeNO cutoff, we identified two distinct phenotypic responses: the FeNO < 25 ppb cohort exhibited significant post-BPA FeNO elevation alongside comprehensive improvements in pulmonary function, cardiac structure-function, hemodynamics, and cardiopulmonary exercise capacity; in contrast, the FeNO ≥ 25 ppb group demonstrated isolated hemodynamic benefits without meaningful changes in FeNO or pulmonary function.This discovery not only provides a new biomarker for the individualized evaluation of BPA treatment efficacy but also offers key evidence for an in-depth understanding of the association between the pathophysiological mechanisms of CTEPH and the therapeutic benefits of BPA. Association between Dynamic Changes in FeNO and BPA Treatment Response and Mechanistic Exploration. 1. In the FeNO < 25 ppb subgroup (n=46), post-BPA FeNO increased from 13.96±5.37 to 19.89±8.20 ppb (P<0.001), coinciding with significant improvements in forced vital capacity (FVC: 2.57 vs. 2.76 L, P=0.006), left ventricular end-systolic diameter (LVES: 4.22 vs. 4.86 cm, P<0.001), mean pulmonary arterial pressure (mPAP: 43.65 vs. 26.96 mmHg, P<0.001), and peak oxygen uptake (PeakV'O2: 843.11 vs. 967.39 mL/min, P=0.019). This synergy strongly suggests FeNO elevation reflects restored endothelial nitric oxide synthase (eNOS)-mediated NO production. Pathophysiologically, CTEPH is characterized by macrovascular thrombo-occlusion and secondary microvascular remodeling, both of which impair endothelial oxygenation and eNOS activity[27].BPA reverses this by dilating occluded segmental/sub-segmental arteries (6–14 vessels per session), restoring pulmonary blood flow and reducing shear stress on endothelial cells[28]. Preclinical studies have shown that improved endothelial oxygenation downregulates oxidative stress markers (e.g., malondialdehyde) and upregulates eNOS phosphorylation[29], directly increasing NO bioavailability. Our observation of a negative correlation between baseline FeNO and post-BPA mPAP change (R=-0.293, P=0.048) aligns with this: lower baseline FeNO likely indicates more severe pre-existing eNOS dysfunction, and BPA-induced hemodynamic normalization drives a more pronounced NO synthesis rebound [22]. Notably, DLCO remained unchanged in this subgroup (P=0.243), consistent with prior reports that DLCO serves as a marker of irreversible microvascular damage in CTEPH [30]. However, the negative correlation between baseline FeNO and post-BPA DLCO change (R=-0.340, P=0.021) suggests that FeNO may still capture subtle microvascular recovery—an effect not detectable by standard DLCO metrics. 2. The FeNO ≥ 25 ppb subgroup (n=11) displayed a fundamentally different response: while PVR decreased significantly (5.33 vs. 3.03 Wood units, P=0.003), FeNO remained stable (30 vs. 29 ppb, P=0.110) and pulmonary function (e.g., FVC: 2.89 vs. 2.93 L, P=0.527) and NT-proBNP (159.3 vs. 75.6 pg/mL, P=0.123) showed no meaningful improvements. This dissociation highlights the limitations of BPA in addressing non-macrovascular components of CTEPH pathophysiology. Two key mechanistic explanations emerge. First, baseline hemodynamics in this subgroup were less severe (mPAP: 36 vs. 43.65 mmHg, P=0.047; PVR: 5.33 vs. 7.78 Wood units, P=0.022)[31], leaving less room for BPA-mediated improvement. Second, the strong negative correlation between baseline FeNO and DLCO (R=-0.650, P=0.030) suggests elevated FeNO reflects underlying microvascular inflammation—likely driven by inducible nitric oxide synthase (iNOS) upregulation—rather than isolated eNOS dysfunction[32].Unlike eNOS, iNOS is induced by pro-inflammatory cytokines (e.g., TNF-α, IL-6) in response to microvascular injury, and its activity is unaffected by macrovascular recanalization[27]. This is supported by prior work showing iNOS-derived NO contributes to "dysfunctional" FeNO elevation in pulmonary hypertension with microvascular involvement[33]. The isolated improvement in oxygen uptake efficiency plateau (OUEP: 26.77 vs. 31.04, P=0.012) further reinforces this phenotype: OUEP reflects metabolic efficiency rather than cardiopulmonary reserve, suggesting BPA only optimizes oxygen delivery to pre-existing functional microvasculature without addressing inflammatory microvascular damage [11]. Clinical Value of FeNO as a Predictive Biomarker for BPA Treatment Response. 1. Current CTEPH guidelines rely on imaging (e.g., CTPA, V/Q scintigraphy) and right heart catheterization (RHC) to select BPA candidates, but these do not capture endothelial or microvascular status[1]. Our data show FeNO < 25 ppb predicts superior multi-domain response: compared to FeNO ≥ 25 ppb, this group had larger improvements in FeNO (P=0.001), LVED (P=0.033), LVES (P=0.035), and mPAP (P=0.014). FeNO’s advantages—non-invasiveness, low cost, and alignment with ATS/ERS standardization[34]—make it ideal for integrating into pre-BPA workups. For example, FeNO < 25 ppb could identify patients most likely to benefit from BPA, while FeNO ≥ 25 ppb may prompt consideration of adjunctive therapies (e.g., anti-inflammatories, targeted microvascular agents)[28]. 2. Complementarity with Existing Biomarkers FeNO fills critical gaps in current biomarker panels. NT-proBNP, a marker of cardiac stress, only correlated with response in the FeNO < 25 ppb group (P0.240) [31], limiting its utility for monitoring. FeNO, by contrast, integrates both endothelial function (eNOS) and inflammation (iNOS) signals: a post-BPA FeNO increase confirms eNOS restoration, while stable elevated FeNO flags unaddressed microvascular inflammation. This dual utility was exemplified by our finding that FeNO ≥ 25 ppb patients with low DLCO may benefit from combined BPA and anti-inflammatory therapy—an insight unobtainable with NT-proBNP or DLCO alone[35]. The innovation points of this study are noteworthy and can be highlighted as follows: 1. This study is the first systematic investigation into the dynamic changes in FeNO before and after BPA treatment in patients with inoperable CTEPH, filling a gap in the field of research. 2. By stratifying using a baseline FeNO threshold of 25 ppb, two distinct treatment response phenotypes were identified: patients with FeNO < 25 ppb showed comprehensive improvement in multiple functional dimensions postoperatively, while those with FeNO ≥ 25 ppb exhibited only partial hemodynamic improvement. 3. The predictive value of FeNO was confirmed: in the FeNO < 25 ppb group, baseline FeNO was negatively correlated with postoperative mPAP improvement, indicating that FeNO can serve as a predictive biomarker for the efficacy of BPA treatment. Limitations: 1 Study Limitations: This study has three key limitations. First, the single-center, small sample size (n=57; FeNO ≥ 25 ppb, n=11) raises concerns about selection bias and statistical power, particularly for subgroup analyses. Second, unmeasured confounders—including nitrate intake (which affects FeNO), upper respiratory infections (which upregulate iNOS), and concurrent medications (e.g., riociguat, which modulates NO)—may have influenced results. Third, lack of long-term follow-up (e.g., 12–24 months) prevents assessment of FeNO’s prognostic value for hard outcomes (e.g., right heart failure, mortality). Finally, we did not measure eNOS/iNOS expression or NO metabolites (e.g., nitrite), limiting direct mechanistic validation. Conclusion This study establishes baseline FeNO as a clinically actionable biomarker for BPA response in inoperable CTEPH. Patients with FeNO < 25 ppb derive comprehensive benefits from BPA, reflecting restored eNOS-mediated NO production and macrovascular-microvascular synergy. In contrast, FeNO ≥ 25 ppb identifies a phenotype with isolated hemodynamic response, likely due to unaddressed iNOS-driven microvascular inflammation. These findings advocate for FeNO-guided personalized care: FeNO < 25 ppb prioritizes BPA, while FeNO ≥ 25 ppb warrants BPA plus adjunctive therapy. Future work to validate FeNO in larger cohorts and explore targeted therapies for high-FeNO patients will further advance CTEPH precision medicine. Abbreviations BNP brain natriuretic peptide FeNO fractional exhaled nitric oxide PFT pulmonary function tests FVC forced vital capacity FEV1 forced expiratory volume in 1 s TLC total lung capacity DLCO diffusing capacity of the lung for carbon monoxide PAP pulmonary artery pressure RHC Right heart catheterization PVR pulmonary vascular resistance PAWP pulmonary artery wedge pressure CO Cardiac output RAP Right atrial pressure RVP Right ventricular pressure CI Cardiac input CPET cardiopulmonary exercise testing V'O2 Oxygen uptake V'CO2 Carbon dioxide output VE/VCO2 Ventilation/Carbon dioxide output OUEP Oxygen Uptake Efficiency Plateau OUES Oxygen Uptake Efficiency Slope TTE transthoracic echocardiography LVED Left ventricle end-diastolic diameter LVES Left ventricle end-systolic diameter TAPSE tricuspid annular plane systolic excursion. BMI:body mass index WHO World Health Organization NOS nitric oxide synthase COPD Chronic Obstructive Pulmonary Disease Declarations Ethics approval and consent to participate All patients in this study were informed at admission that their medical records were likely to be used for clinical studies. Ethical approval by the medical ethics committee of Shanghai pulmonary hospital was obtained. Consent for publication Not applicable. Availability of data and materials All the related data are presented in the manuscript. Competing interests The authors confirm that there are no conflicts of interest Funding This study was supported by the Scientific research project of Shanghai Municipal Health Commission [202040321] and the Clinical research project of Shanghai Pulmonary Hospital [FKLY20020]. Contributorship statement ： Conceived and designed the experiments: JHX JG. Performed the experiments: XXS YC WLY TRZ. Analyzed the data: JHX MH XXS JG. 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Fractional Exhaled Nitric Oxide Measurement in Pulmonary Hypertension: A Follow-Up Study. Clin Appl Thromb Hemost. 2018;24(3):483–8. Nguyen TC, Tran HVT, Nguyen TH, et al. Fractional exhaled nitric oxide (FeNO) in chronic obstructive respiratory diseases is associated with the bronchodilator response[J]. J Thorac Dis. 2025;17(11):9874–84. Nilsson KF, Gustafsson LE, Adding LC, et al. Increase in exhaled nitric oxide and protective role of the nitric oxide system in experimental pulmonary embolism. Br J Pharmacol. 2007;150(4):494–501. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8420176","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":577749252,"identity":"a6a18513-6062-4a79-bcaf-fbb0646e1271","order_by":0,"name":"jianhua xu","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA1ElEQVRIie3RsQrCMBCA4SuFuAS6pgh5A+GgIBakfZUEoVMfwLEScKpv0LcQOgcKnRTXbrYITl3cuik6iUvjJph//7g7DsBm+8G8iapaMSxpfFLajPh5nWCXJxyaWpgRbFL0W1IFoFM03EwnAgV15SY73JoeIj7LRoSTVboVCyKVu9uHBayCuR4hrrN9TqFyC8dySkHLcowQlyIThMkc0qsZoeRFMGCQEjPCKElQ5oIjq4OwQINb4vOl6obhTtFTXdOvIz5KPkaavuaNfCtsNpvtL3oA5yJEfWxCMawAAAAASUVORK5CYII=","orcid":"","institution":"Department of Pulmonary Function Test, Shanghai Pulmonary Hospital, School of Medicine, Tongji University","correspondingAuthor":true,"prefix":"","firstName":"jianhua","middleName":"","lastName":"xu","suffix":""},{"id":577749253,"identity":"1fb373b1-0e3e-4b16-8017-5a23da1a924d","order_by":1,"name":"Mian He","email":"","orcid":"","institution":"Department of Pulmonary Function Test, Shanghai Pulmonary Hospital, School of Medicine, Tongji University","correspondingAuthor":false,"prefix":"","firstName":"Mian","middleName":"","lastName":"He","suffix":""},{"id":577749254,"identity":"b6cf4d71-cab3-4046-842c-d5567a284548","order_by":2,"name":"Xingxing Sun","email":"","orcid":"","institution":"Department of Pulmonary Function Test, Shanghai Pulmonary Hospital, School of Medicine, Tongji University","correspondingAuthor":false,"prefix":"","firstName":"Xingxing","middleName":"","lastName":"Sun","suffix":""},{"id":577749255,"identity":"6ffec845-0088-4f39-be2f-9db208591e15","order_by":3,"name":"Tianran Zhou","email":"","orcid":"","institution":"Department of Pulmonary Function Test, Shanghai Pulmonary Hospital, School of Medicine, Tongji University","correspondingAuthor":false,"prefix":"","firstName":"Tianran","middleName":"","lastName":"Zhou","suffix":""},{"id":577749256,"identity":"8aeefa0f-ab1b-4313-9b30-9e61ff7d5ce8","order_by":4,"name":"Hanqing Zhu","email":"","orcid":"","institution":"Department of Pulmonary Function Test, Shanghai Pulmonary Hospital, School of Medicine, Tongji University","correspondingAuthor":false,"prefix":"","firstName":"Hanqing","middleName":"","lastName":"Zhu","suffix":""},{"id":577749257,"identity":"fcabaa28-607d-4096-983b-14e6834f735b","order_by":5,"name":"Wenlan Yang","email":"","orcid":"","institution":"Department of Pulmonary Function Test, Shanghai Pulmonary Hospital, School of Medicine, Tongji University","correspondingAuthor":false,"prefix":"","firstName":"Wenlan","middleName":"","lastName":"Yang","suffix":""},{"id":577749258,"identity":"2d0fc793-105c-4e1a-8769-40d456093b36","order_by":6,"name":"Jinming Liu","email":"","orcid":"","institution":"Department of Pulmonary Circulation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University","correspondingAuthor":false,"prefix":"","firstName":"Jinming","middleName":"","lastName":"Liu","suffix":""},{"id":577749259,"identity":"e897549d-2ec2-4984-81b4-f3a7464d6976","order_by":7,"name":"Jian 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14:17:46","extension":"xml","order_by":9,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":180778,"visible":true,"origin":"","legend":"","description":"","filename":"9f6e787fce7b4758a77aad3a940e4f2f1structuring.xml","url":"https://assets-eu.researchsquare.com/files/rs-8420176/v1/e555f0a9902f849298e8b545.xml"},{"id":100896838,"identity":"ac0978b1-90f8-4ded-9742-e29132989acb","added_by":"auto","created_at":"2026-01-22 14:17:46","extension":"html","order_by":10,"title":"","display":"","copyAsset":false,"role":"acdc-reference","size":196164,"visible":true,"origin":"","legend":"","description":"","filename":"earlyproof.html","url":"https://assets-eu.researchsquare.com/files/rs-8420176/v1/2b6a4433ff548704c61e57ba.html"},{"id":101202610,"identity":"be862bde-fe90-42dc-b030-6dab764cfa07","added_by":"auto","created_at":"2026-01-27 09:36:43","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":68906,"visible":true,"origin":"","legend":"\u003cp\u003eFigure 2. (A) Comparative analysis of FeNO pre- and post-BPA intervention in the group with FeNO\u0026lt;25.(B) Comparative analysis of FeNO pre- and post-BPA intervention in the group with FeNO≥25. (C) Comparative analysis of NT-proBNP concentrations pre-BPA and post-BPA intervention in the group with FeNO\u0026lt;25. (D) Comparative analysis of NT-proBNP concentrations pre- and post-BPA intervention in the group with FeNO≥25.\u003c/p\u003e","description":"","filename":"floatimage1.png","url":"https://assets-eu.researchsquare.com/files/rs-8420176/v1/1416242fbce5f637b4898133.png"},{"id":100950159,"identity":"00d67372-71a0-43ab-bf2b-f83502748066","added_by":"auto","created_at":"2026-01-23 07:07:03","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":120687,"visible":true,"origin":"","legend":"\u003cp\u003eFigure3. (A-B) Differences in mPAP and mPAP change between the group with FeNO\u0026lt;25 and the group with FeNO≥25.(C-D) Differences in PVR and PVR change between the group with FeNO\u0026lt;25 and the group with FeNO≥25. (E-F) Differences in SLOPE and SLOPE change between the group with FeNO\u0026lt;25 and the group with FeNO≥25. (G-H) Differences in OUES and OUES change between the group with FeNO\u0026lt;25 and the group with FeNO≥25.\u003c/p\u003e","description":"","filename":"floatimage2.png","url":"https://assets-eu.researchsquare.com/files/rs-8420176/v1/88ff2f39fa287a36be1850a7.png"},{"id":100896830,"identity":"a6c7ba9c-1c67-4cfc-80d0-1557351210a0","added_by":"auto","created_at":"2026-01-22 14:17:46","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":106347,"visible":true,"origin":"","legend":"\u003cp\u003eFigure4. (A-B) Associations of FeNO with baseline mPAP and mPAP change in FeNO\u0026lt;25. (C-D) Associations of FeNO with baseline mPAP and mPAP change in FeNO≥25.\u003c/p\u003e","description":"","filename":"floatimage3.png","url":"https://assets-eu.researchsquare.com/files/rs-8420176/v1/bde8ab4a652bdddfb55921c4.png"},{"id":102755071,"identity":"f4f45499-1498-4b9c-aa04-e06eff64444b","added_by":"auto","created_at":"2026-02-16 09:41:31","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1331363,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-8420176/v1/a0a49bdb-0e80-431d-ad2c-9e64167667ff.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Predictive Value and Clinical Correlation of Baseline FeNO Levels for Balloon Pulmonary Angioplasty Efficacy in Patients with Inoperable chronic thromboembolic pulmonary hypertension","fulltext":[{"header":"Introduction","content":"\u003cp\u003eCTEPH belongs to the fourth major classification of pulmonary hypertension (PH)[\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. It is a debilitating condition marked by the obstruction of pulmonary vessels due to thrombotic occlusion, leading to progressive stenosis or occlusion, a surge in pulmonary vascular resistance, and elevated pulmonary artery pressure. Ultimately, this cascade of events culminates in right-sided heart failure[\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e]. While the exact incidence of CTEPH remains elusive, it is approximated that approximately 3% of individuals who have experienced an acute pulmonary embolism will develop CTEPH. In the absence of timely intervention, the prognosis for CTEPH patients is grim, with their survival prospects intimately tied to the severity of the hemodynamic manifestations of PH[\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e, \u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eCTEPH, though potentially curable through pulmonary endarterectomy (PEA), has demonstrated remarkable post-operative survival rates and functional improvements. However, it is noteworthy that over half of CTEPH patients are either ineligible for surgery or experience persistent or recurrent PH following PEA[\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e, \u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. For these inoperable patients and those with residual symptomatic PH post-PEA, medical therapy has emerged as the current gold standard of care[\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e]. Despite the availability of effective medical treatments, a substantial proportion of inoperable CTEPH patients continue to suffer from persistent symptoms and limited exercise tolerance. Fortunately, in recent years, BPA has emerged as a promising therapeutic alternative for this challenging patient population. BPA offers a minimally invasive approach to improving pulmonary hemodynamics and alleviating symptoms by dilating obstructed pulmonary vessels and restoring blood flow to previously lung regions. By precisely targeting the characteristic vascular obstructions in CTEPH, BPA holds the potential to significantly enhance exercise tolerance and overall quality of life for these patients[\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e]. Several studies have documented the substantial improvement in hemodynamics and functional outcomes among CTEPH patients who have undergone BPA[\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e, \u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e]. Furthermore, improvements in ventilatory efficiency and pulmonary gas exchange have also been reported following BPA procedures[\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e], However, the specific mechanisms by which it improves pulmonary circulation and cardio-pulmonary function have not been fully elucidated.\u003c/p\u003e \u003cp\u003eFeNO serves as a valuable biomarker for assessing airway inflammation. It is generated through the catalytic action of nitric oxide synthase (NOS) and is present in various tissues including blood vessels, nerves, inflammatory cells, and the airway epithelium[\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e]. On the one hand, in the state of airway inflammation, inflammatory factors can induce upregulation of NOS activity, promoting the massive release of NO, which leads to elevated FeNO levels. Therefore, FeNO can reflect the degree of airway inflammation[\u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eOn the other hand, NO, as a core vasodilator secreted by pulmonary vascular endothelial cells, is a key molecule in regulating pulmonary vascular tone[\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e]. Its abnormal synthesis and release are closely related to pulmonary vascular remodeling.In the pathological process of CTEPH, pulmonary vascular endothelial injury and microcirculatory disorders caused by thrombus obstruction are core links in disease progression. Studies have shown that CTEPH patients have abnormal expression of endothelial nitric oxide synthase (eNOS), which is the main source of NO synthesis in the pulmonary circulation. Downregulation of eNOS leads to insufficient endogenous NO production, thereby exacerbating pulmonary vasoconstriction and remodeling, and promoting the progression of pulmonary hypertension[\u003cspan additionalcitationids=\"CR16\" citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eMeanwhile, CTEPH patients not only have large vessel thrombotic obstruction but also commonly exhibit lesions in distal small vessels. This microcirculatory damage directly affects the efficiency of pulmonary gas exchange, and pulmonary carbon monoxide diffusion capacity (DLCO) is a core indicator for evaluating microcirculatory function[\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e]. Existing studies have found that FeNO levels are associated with pulmonary microcirculatory function; in patients with pulmonary hypertension complicated by interstitial lung disease, elevated FeNO can reflect microvascular dysfunction[\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e]. However, research on the specific association between FeNO and microcirculatory injury, endothelial dysfunction in CTEPH patients remains relatively scarce.\u003c/p\u003e \u003cp\u003eExisting studies on the efficacy of BPA have primarily focused on hemodynamic improvement (such as reduced mean pulmonary arterial pressure and pulmonary vascular resistance)[\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e] and recovery of exercise function[\u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e], without incorporating endothelial function and inflammatory markers like FeNO into the efficacy evaluation system. Furthermore, in other types of pulmonary arterial hypertension such as idiopathic pulmonary arterial hypertension (IPAH), FeNO has been confirmed to predict the efficacy of targeted drug therapy[\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e]. However, the pathogenic mechanisms of CTEPH (thrombotic obstruction\u0026thinsp;+\u0026thinsp;vascular remodeling) and IPAH (idiopathic vascular remodeling) are fundamentally different, and the predictive value of FeNO in CTEPH treatment and the effect of BPA on its levels remain unclear.\u003c/p\u003e \u003cp\u003eGiven the close association of FeNO with pulmonary vascular endothelial function and microcirculatory status, as well as the gap in mechanism research on BPA treatment for CTEPH, this study aims to analyze the changes in FeNO levels before and after BPA treatment in patients with non-surgical CTEPH, and their correlations with indicators such as lung function, hemodynamics, and cardiopulmonary exercise capacity. This will provide a theoretical basis for revealing the mechanism by which BPA improves pulmonary circulation function and optimizing individualized treatment strategies for CTEPH.\u003c/p\u003e"},{"header":"Patients and Methods","content":"\u003cp\u003eEthical approval\u003c/p\u003e\n\u003cp\u003eThe study protocol was thoroughly reviewed and approved by the Ethics Committee of Shanghai Pulmonary Hospital. All methods, including echocardiography, measurement of brain natriuretic peptide (NT-proBNP), RHC, CPET, PFT, and FeNO measurements, were conducted in strict accordance with the applicable guidelines and regulations. All our participants have provided informed consent.\u003c/p\u003e\n\u003cp\u003ePatients\u003c/p\u003e\n\u003cp\u003eThis study proactively enrolled 57 patients diagnosed with CTEPH, who underwent evaluation at Shanghai Pulmonary Hospital between May 2019 and June 2024. All patients referred for BPA. Eligibility criteria and techniques used to perform BPA were similar to those described elsewhere[23]. A comprehensive workup encompassed clinical assessment, RHC, echocardiography, CPET, and PFT. These evaluations were conducted initially at the baseline stage during the diagnosis of CTEPH and subsequently reassessed at least 2 sessions BPA. Each parameter was examined before first BPA and 6 months after last BPA. Patients whose PH-directed therapy underwent any alterations between the two workup periods were excluded from the analysis. Additionally, individuals with a pulmonary arterial wedge pressure (PAWP) exceeding 15 mmHg were also disqualified from the study. In addition, patients with concurrent chronic pulmonary diseases such as COPD and asthma are also excluded.\u003c/p\u003e\n\u003cp\u003ePFT\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eWe conducted pulmonary function tests, using standard equipment (Masterscreen-PFT, Jaeger crop, Hoechberg, Germany) and following the guidelines recommended by the European Respiratory Society (ERS)[24]. The following parameters were determined: Forced Vital Capacity(FVC), FVC% predicted, Forced Expiratory Volume in one second(FEV1), FEV1% predicted, diffusing capacity for lung carbon monoxide(DLCO), DLCO% predicted, total lung capacity (TLC), TLC% predicted[25].\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eFeNO\u003c/p\u003e\n\u003cp\u003eThe FeNO levels were meticulously evaluated utilizing a state-of-the-art electrochemical breath analyzer sourced from Shangwo Medical Electronics in Wuxi, China. To eliminate any potential confounders arising from food or beverage consumption, patients were thoroughly instructed to abstain from any form of ingestion for a minimum period of two hours preceding the FeNO measurement. During the measurement process, patients were guided to maintain a consistent and even breathing pattern, encompassing at least two complete breath cycles. Importantly, they were instructed to exhale at a constant and controlled airflow rate of 50 mL/s for a duration of 10 seconds. To further enhance the robustness of the data, FeNO levels were measured in triplicate for each patient, under carefully maintained stable conditions. This repetitive measurement protocol was implemented to ensure that any variations between readings were minimal, with a strict criterion of no more than 10% difference among the measurements.\u003c/p\u003e\n\u003cp\u003eRHC\u003c/p\u003e\n\u003cp\u003eAll patients diagnosed with CTEPH underwent a rigorous RHC procedure. During this procedure, a precision True Size Thermodilution Catheter (model 774 by Edward Lifesciences) was meticulously inserted via the left cubital vein. The comprehensive hemodynamic assessment encompassed several critical parameters, including Right Atrium Pressure (RAP), Right Ventricular Pressure (RVP), mPAP, and pulmonary artery wedge pressure (PAWP), Cardiac output (CO), Cardiac input (CI), PVR was precisely calculated using established formulas, specifically PVR = (mPAP – PAWP)/CO.\u003c/p\u003e\n\u003cp\u003eTTE (transthoracic echocardiography)\u003c/p\u003e\n\u003cp\u003eTransthoracic echocardiography, utilizing a commercially accessible system (Vivid 7 Dimension), was conducted at the commencement of the study and reiterated in the third month, ensuring consistency through the same physician's expertise. The primary metrics garnered from these scans encompassed the systolic pulmonary artery pressure (PAP systolic), the dimensions of the right atrium and right ventricle, alongside key left ventricular parameters such as the LVED, LVES, and the tricuspid annular plane systolic excursion (TAPSE). This comprehensive assessment allowed for a thorough evaluation of cardiac function and structure.\u003c/p\u003e\n\u003cp\u003eBPA\u003c/p\u003e\n\u003cp\u003eThe BPA procedure and all materials are similar to this study(20)[26]. Pulmonary angiography was performed selectively in anterior-posterior and lateral (45 degree) projections after RHC to acquire overall view about the position and degree of filling defect in combination with previous ventilation/perfusion scintigraphy. The procedure of BPA was systematically executed via the right femoral vein by two highly skilled interventional cardiologists. To gain access, we delicately approached the femoral vein and inserted a 6 French (Fr) guiding sheath into the main pulmonary artery with precision. Subsequently, a versatile 6 Fr guiding catheter (such as Profit®, Multipurpose, or Judkins right and left 4.0 models, manufactured by Goodman in Nagoya, Aichi, Japan) was threaded through the peripheral guiding sheath and meticulously advanced towards the targeted vessels. Relying on meticulous selective pulmonary angiography, a 0.014-inch guide wire (specifically, the Athlete Bpahm® from Japan Lifeline in Tokyo, Japan) was skillfully navigated across the targeted lesion. Depending on the duration allowed for the procedure, each session entailed the treatment of 6 to 14 segmental or sub-segmental arteries, ensuring comprehensive care for the patient's condition.\u003c/p\u003e\n\u003cp\u003eCPET\u003c/p\u003e\n\u003cp\u003eCPET was performed utilizing an advanced, electromagnetically braked cycle ergometer (Master Screen CPX, Jaeger Crop, Hoechberg, Germany). The comprehensive protocol encompassed four distinct stages: an initial 3-minute rest period, followed by a 3-minute unloaded cycling phase, an incremental workload phase, and a final 5-minute recovery phase. A wide array of physiological parameters was meticulously recorded and calculated, including PeakLaod, PeakV'O2 (Oxygen uptake), PeakV'CO2 (Carbon dioxide output), PeakPETO2(Peak End-Tidal Oxygen Partial Pressure), PeakPETCO2(Peak End-Tidal Carbon Dioxide Partial Pressure), PeakVE/VCO2 (Ventilation/Carbon dioxide output), OUEP (Oxygen Uptake Efficiency Plateau), VE/VCO2 slope (SLOPE), OUES.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe statistical analyses were meticulously conducted utilizing the SPSS 22.0 and GraphPad Prism 5 software packages. The data were presented as either as mean±SD or frequency and median (interquartile range). To assess the normality of the data distributions, the rigorous Shapiro–Wilk test was employed. For the comparison of differences between two independent groups, an independent sample t-test was utilized. To evaluate changes in indexes before and after BPA treatment, a paired sample t-test was appropriately applied, capturing the intragroup variations. In cases where data failed to adhere to normal distribution, the Wilcoxon Signed-Rank Test was invoked. For normally distributed data, Pearson correlation coefficients were used, while for non-normal distributions, Spearman correlation coefficients were applied. Mann-Whitney U test for continuous variables, chi-square test for categorical variables. A p-value less than 0.05 was deemed statistically significant throughout the analysis. \"Change\" refers to (post-BPA FeNO) − (pre-BPA FeNO).\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003eClinical characteristics in CTEPH\u003c/p\u003e\n\u003cp\u003eBaseline characteristics of CTEPH patients stratified by FeNO levels are summarized in Table 1. No significant differences were observed between the FeNO\u0026lt;25 ppb (n=46) and FeNO\u0026ge;25 ppb (n=11) groups in terms of sex distribution (15M/31F vs 3M/8F, p=0.737), age (median 62 vs 63 years, p=0.585), or BMI (median 23.85 vs 24.88 kg/m\u0026sup2;, p=0.293). Although WHO functional class distribution trended toward significance (p=0.147), with more patients in Class III\u0026ndash;IV in the FeNO\u0026ge;25 group (5/11 vs 30/46), this did not reach statistical threshold. Comorbid disease prevalence varied between groups, with hypertension (12 vs 4 cases) and pulmonary embolism (25 vs 5 cases) being most frequent. Notably, no patients in the FeNO\u0026ge;25 group had diabetes mellitus (0/11). Pharmacotherapy patterns showed riociguat monotherapy as the most common regimen (29/46 vs 8/11), while combination therapies (e.g., macitentan-riociguat) were less frequently used. Statistical comparisons for comorbidities and medications were not performed due to small subgroup sizes.\u003c/p\u003e\n\u003cp\u003eTable 1. Baselinely characteristics, comorbidities, and medication regimens in patients with CTEPH, stratified by FeNO levels (FeNO\u0026lt;25 ppb vs FeNO\u0026ge;25 ppb).\u003c/p\u003e\n\u003ctable border=\"0\" cellspacing=\"0\" cellpadding=\"0\" width=\"564\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eFactors\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003eFeNO\u0026lt;25(n=46)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003eFeNO\u0026ge;25(n=11)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003eP值\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eSex, M/F\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e15/31\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e3/8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e0.737\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eAge, years\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e62(54.75,70)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e63(55,73)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e0.585\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eBMI, kg/m2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e23.85(22.13,26.12)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e24.88(23.50,26.78)\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e0.293\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eWHO functional class, n\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eClass I, II/III, IV\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e16/30\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e6/5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e0.147\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eComorbid diseases\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eHypertension\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e12\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e4\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eDiabetes mellitus\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003edeep vein thrombosis\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e7\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003ecoronary artery disease\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e3\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003epulmonary embolism\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e25\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eMedication\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eSildenafil+Macitentan\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eRiociguat\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e29\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eAmbrisentan+Riociguat\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e5\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eMacitentan+Riociguat\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e8\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e2\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eBosentan+Riociguat\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e0\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 162px;\"\u003e\n \u003cp\u003eAmbrisentan+Sildenafil\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 152px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 165px;\"\u003e\n \u003cp\u003e1\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 85px;\"\u003e\n \u003cp\u003e\u0026nbsp;\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003eThe data are presented as frequency. BMI = body mass index; IQR = interquartile range; FeNO = fractional exhaled nitric oxide.\u003c/p\u003e\n\u003cp\u003eDifferences in lung function, hemodynamics and CPET after BPA treatment, stratified by FeNO levels\u003c/p\u003e\n\u003cp\u003eIn the FeNO \u0026lt;25 ppb cohort (n=46), BPA resulted in significant improvements across multiple domains: Biomarkers: Pulmonary Function: Both FVC(p=0.006) and FVC% predicted (p=0.006) improved significantly; Hemodynamics: mPAP and PVR demonstrated clinically meaningful reductions; Exercise Capacity: Enhanced performance was observed in multiple CPET parameters. Notably, FeNO levels increased post-BPA from 13.96\u0026plusmn;5.37 to 19.89\u0026plusmn;7.21 ppb (p\u0026lt;0.001) (Figure. 2A). NT-proBNP levels decreased markedly (p\u0026lt;0.001) (Figure. 2C), indicating reduced cardiac stress; The smaller FeNO \u0026ge;25 ppb cohort (n=11) exhibited distinct response patterns: Hemodynamic Benefits: Similar to the FeNO \u0026lt;25 group, significant reductions in PVR were achieved (7.78 [6.21,10.32] vs 3.37 [2.64,4.14] Wood units, p\u0026lt;0.001). Non-significant Changes: FeNO (p=0.110) (Figure. 2B), NT-proBNP (p=0.123) (Figure. 2D), and spirometric parameters showed no statistically significant improvements. OUEP improved significantly (+15.9%, p=0.012) despite unchanged peak exercise metrics, suggesting enhanced metabolic efficiency.\u003c/p\u003e\n\u003cp\u003eDespite hemodynamic improvements, DLCO failed to improve significantly in either group post-BPA (FeNO \u0026lt;25: p=0.243; FeNO \u0026ge;25: p=0.374). This finding suggests that: residual small vessel disease may persist despite macrovascular recanalization, DLCO could serve as a marker for microvascular involvement in CTEPH(11). Combination therapies targeting both vascular beds may be warranted for comprehensive disease modification. \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTable 2. Comparative analysis of pre- and post-BPA parameters in patients with CTEPH, stratified by baseline FeNO levels.\u003c/p\u003e\n\u003cdiv style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:115%;font-size:15px;font-family:\"Times New Roman\",serif;'\u003e\n \u003ctable style=\"border: none;border-collapse: collapse;width: 708px;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFactors\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003ePre-BPA\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;font-family:SimSun;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003en=46\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;font-family:SimSun;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003ePost-BPA\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;font-family:SimSun;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003en=46\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;font-family:SimSun;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eP\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;font-family:SimSun;\"\u003e值\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003ePre-BPA\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;font-family:SimSun;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003en=11\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;font-family:SimSun;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003ePost-BPA\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;font-family:SimSun;\"\u003e（\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003en=11\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;font-family:SimSun;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eP\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;font-family:SimSun;\"\u003e值\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:229.85pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFeNO\u0026lt;25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:219.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFeNO\u0026ge;25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:5.5pt;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:11.25pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eNT-proBNP,\u003c/span\u003e \u003cspan style=\"font-size:10px;line-height:150%;\"\u003epg/mL\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e337.5(90.45,970.08)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e89(43,185.03)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;color:red;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e159.3(39,212.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e75.6(51.2,137.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.123\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFeNO, ppb\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e13.96\u0026plusmn;5.37\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e19.89\u0026plusmn;8.20\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;color:red;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e30(28,48)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e29(13,39)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.110\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003ePFT\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;padding: 0cm 5.4pt;height: 30.4pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0cm 5.4pt;height: 30.4pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFVC, L\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.57(2.33,3.05)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.76(2.34,3.01)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;color:red;\"\u003e0.006\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.89\u0026plusmn;0.80\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.93\u0026plusmn;0.89\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.527\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFVC% predicted\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e88.08\u0026plusmn;10.70\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e91.50\u0026plusmn;10.88\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;color:red;\"\u003e0.006\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e91.84\u0026plusmn;11.47\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e93.37\u0026plusmn;9.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.539\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFEV1, L\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.04(1.7,2.37)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.05(1.8,2.35)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.082\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.28\u0026plusmn;0,76\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.29\u0026plusmn;0.83\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.875\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFEV1% predicted\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e84.2(77.8,92.4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e87.05(77.62,94.48)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.061\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e89.09\u0026plusmn;13.67\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e89.75\u0026plusmn;12.22\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.813\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFEV1/FVC% predicted\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e93.52\u0026plusmn;7.88\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e92.14\u0026plusmn;6.65\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.121\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e94.80\u0026plusmn;8.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e93.6\u0026plusmn;6.44\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.421\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eTLC, L\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e4.87(4.29,5.60)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e4.79(4.28,5.42)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.935\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e4.96\u0026plusmn;0.92\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e5.03\u0026plusmn;0.82\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.520\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eTLC% predicted\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e100.6(92.95,107.55)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e100.75(92.48,107.88)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.864\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e99.71\u0026plusmn;10.28\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e101.3\u0026plusmn;11.12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.598\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eDLCO, mL/(mmHg\u0026middot;min)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e16.77(13.77,20.03)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e16.4(14.71,19.05)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.243\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e15.08(12.86,16.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e13.57(11.24,20.11)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.374\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eDLCO% predicted\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e90.7(81.3,103.55)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e91.4(84.3,99.8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.417\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e83.95\u0026plusmn;15.90\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e80.44\u0026plusmn;14.18\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.342\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eTTE\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 88.1pt;padding: 0cm 5.4pt;height: 20.25pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 92.1pt;padding: 0cm 5.4pt;height: 20.25pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.65pt;padding: 0cm 5.4pt;height: 20.25pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 84.95pt;padding: 0cm 5.4pt;height: 20.25pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 3cm;padding: 0cm 5.4pt;height: 20.25pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.6pt;padding: 0cm 5.4pt;height: 20.25pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003ePAP systolic, mm Hg\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e60.5(47.25,84)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e40.5(33.75,49)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;color:red;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e68.55\u0026plusmn;23.33\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e37.27\u0026plusmn;11.29\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eRight atrium, cm\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e3.9(3.275,4.825)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e3.5(3.1,3.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;color:red;\"\u003e0.002\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.54\u0026plusmn;2.34\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.343\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e3(2,5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e4.55\u0026plusmn;2.98\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.474\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eRVP, mmHg\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e6(5,8.25)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e5(4,7)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.066\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e6.8\u0026plusmn;5.33\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e6.64\u0026plusmn;2.84\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.434\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003emPAP, mmHg\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e43.65\u0026plusmn;7.38\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e26.96\u0026plusmn;6.14\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;color:red;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e36(28,48)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e27.45\u0026plusmn;6.22\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;color:red;\"\u003e0.008\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003ePAWP, mmHg\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e7(5,8)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e8(6,10)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;color:red;\"\u003e0.008\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e7.09\u0026plusmn;4.11\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e9.55\u0026plusmn;3.67\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.095\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eCO, L/min\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e4.71\u0026plusmn;1.17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e5.72\u0026plusmn;1.08\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;color:red;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e4.98\u0026plusmn;1.35\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e5.96\u0026plusmn;0.86\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;color:red;\"\u003e0.014\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:82.05pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eCI, L/(min\u0026times;m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.8(2.29,3.19)\u003c/span\u003e\u003c/p\u003e\n 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5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;color:red;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e40.46\u0026plusmn;6.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times 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style=\"font-size:10px;line-height:150%;\"\u003eOUES\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:88.1pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e996.54\u0026plusmn;234.85\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:92.1pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e1143.63\u0026plusmn;282.93\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.65pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;color:red;\"\u003e0.002\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:84.95pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e1227.3\u0026plusmn;419.43\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e1260.88\u0026plusmn;399.31\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:49.6pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.820\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003eThe data are presented as mean\u0026thinsp;\u0026plusmn;\u0026thinsp;SD, frequency and median (interquartile range). The data, which conformed to the orthographic distribution, underwent a paired-samples t-test to statistically evaluate any significant differences before and after BPA treatment. Wilcoxon signed-rank test was used for data that did not conform to normality of distributions. BNP=brain natriuretic peptide; FeNO=fractional exhaled nitric oxide; PFT= pulmonary function tests; FVC=forced vital capacity; FEV1=\u0026thinsp;forced expiratory volume in 1 s; TLC= total lung capacity; DLCO=diffusing capacity of the lung for carbon monoxide; PAP= pulmonary artery pressure; RHC= Right heart catheterization; PVR=pulmonary vascular resistance; PAWP=pulmonary artery wedge pressure; CO=Cardiac output; RAP=Right atrial pressure; RVP=Right ventricular pressure; CI=Cardiac input; CPET=cardiopulmonary exercise testing; V\u0026apos;O2=Oxygen uptake; V\u0026apos;CO2=Carbon dioxide output; VE/VCO2=Ventilation/Carbon dioxide output; OUEP=Oxygen Uptake Efficiency Plateau; TTE= transthoracic echocardiography; LVED=Left ventricle end-diastolic diameter; LVES=Left ventricle end-systolic diameter; TAPSE= tricuspid annular plane systolic excursion; OUES=Oxygen Uptake Efficiency Slope. SLOPE=VE/VCO₂ Slope\u003c/p\u003e\n\u003cp\u003eA comprehensive comparison of treatment responses to BPA in CETPH patients stratified by baseline FeNO levels.\u003c/p\u003e\n\u003cp\u003eBaseline comparisons demonstrated significant between-group differences in key hemodynamic and cardiopulmonary parameters: Patients with FeNO\u0026lt;25 ppb exhibited higher \u0026nbsp;Mpap (43.7\u0026plusmn;7.4 vs 36.0\u0026plusmn;5.2 mmHg, p=0.003), elevated PVR (7.78 [6.21,10.32] vs 5.33 [4.84,8.62] Wood units, p=0.012), steeper ventilatory efficiency slope (SLOPE: 47.29\u0026plusmn;11.00 vs 40.46\u0026plusmn;6.04, p=0.017), and lower oxygen uptake efficiency slope (OUES: 996.5\u0026plusmn;234.9 vs 1227.3\u0026plusmn;419.4, p=0.037) compared to the FeNO\u0026ge;25 ppb group (Figure. 3A-H). No statistically significant differences were observed in other evaluated parameters, including lung function, TTE, or right ventricular function metrics (all p\u0026gt;0.05). Treatment responses analysis revealed distinct improvement patterns between subgroups: The FeNO \u0026lt;25 cohort demonstrated significantly greater improvements in FeNO (p=0.001), LVED (p=0.033), LVES (p=0.035), and mPAP (p=0.014) following intervention. These findings suggest that baseline FeNO levels may serve as a predictive biomarker for differential treatment response in CTEPH patients. The paradoxical association between lower baseline FeNO and superior hemodynamic improvement warrants further investigation into the underlying pathophysiological mechanisms linking nitric oxide metabolism to pulmonary vascular remodeling.\u003c/p\u003e\n\u003cp\u003eTable 3. Comparative analysis of baseline characteristics and treatment response in CTEPH patients stratified by FeNO levels, showing both absolute values and changes after balloon pulmonary angioplasty (BPA).\u003c/p\u003e\n\u003cdiv style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:115%;font-size:15px;font-family:\"Times New Roman\",serif;'\u003e\n \u003ctable style=\"border: none;border-collapse: collapse;width: 714px;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFactors\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFeNO\u0026lt;25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFeNO\u0026ge;25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eP\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;font-family:SimSun;\"\u003e值\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFeNO\u0026lt;25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFeNO\u0026ge;25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eP\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;font-family:SimSun;\"\u003e值\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:239.3pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003ebaseline characteristics\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:208.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003echange\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eNT-proBNP,\u003c/span\u003e \u003cspan style=\"font-size:10px;line-height:150%;\"\u003epg/mL\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e337.5(90.45,970.08)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e159.3(39,212.4)\u003c/span\u003e\u003c/p\u003e\n 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-93.90(-160.40,25.40)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.163\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New 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Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eFEV1/FVC% predicted\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e93.52\u0026plusmn;7.88\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e94.80\u0026plusmn;8.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.259\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-1.38\u0026plusmn;1.58\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-1.20\u0026plusmn;4.70\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.895\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eTLC, L\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e4.87(4.29,5.60)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e4.96\u0026plusmn;0.92\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.926\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.01(-3.02,0.26)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-0.01(-0.12,0.15)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.927\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eTLC% predicted\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e100.6(92.95,107.55)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e99.71\u0026plusmn;10.28\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.553\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e1.89\u0026plusmn;18.36\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-0.20(-6,9.10)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.864\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eDLCO, mL/(mmHg\u0026middot;min)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e16.77(13.77,20.03)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e15.08(12.86,16.2)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.307\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.32(-1.09,1.78)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-0.89(-2.63,0.99)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.145\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eDLCO% predicted\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e90.7(81.3,103.55)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e83.95\u0026plusmn;15.90\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.118\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e3.9\u0026plusmn;17.40\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-3.51\u0026plusmn;11.67\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.229\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eTTE\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 90.45pt;padding: 0cm 5.4pt;height: 20.25pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 3cm;padding: 0cm 5.4pt;height: 20.25pt;vertical-align: bottom;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003ePAP systolic, mm Hg\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e60.5(47.25,84)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e68.55\u0026plusmn;23.33\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.754\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-23.98\u0026plusmn;27.74\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-31.27\u0026plusmn;16.03\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.407\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eRight atrium, cm\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e3.9(3.275,4.825)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e4.23\u0026plusmn;0.91\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.578\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-0.55(-1.13,0.3)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-0.7(-1.10,-0.30)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.466\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eRight ventricle, cm\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e4.07\u0026plusmn;0.76\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e3.6(3.4,3.9)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.538\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-0.56\u0026plusmn;0.69\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-0.7\u0026plusmn;0.83\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.561\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eLVED, cm\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.3(1.95,2.625)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.41\u0026plusmn;0.58\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.291\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.5(0.1,0.83)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-0.1(-0.4,0.5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.033\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eLVES, cm\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e4.22\u0026plusmn;0.71\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e4.46\u0026plusmn;0.64\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.260\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.64\u0026plusmn;0.70\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eTAPSE\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e1.9(1.6,2.15)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.01\u0026plusmn;0.36\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.570\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.19\u0026plusmn;0.47\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.05\u0026plusmn;0.34\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.345\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eRHC\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eRAP, mmHg\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e2.5(2,5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e3(2,5)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.886\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-0.57\u0026plusmn;3.31\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.91\u0026plusmn;4.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.209\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eRVP, mmHg\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e6(5,8.25)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e6.8\u0026plusmn;5.33\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.706\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-0.5(-4,1)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-2(-3,4)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.394\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003emPAP, mmHg\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e43.65\u0026plusmn;7.38\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003ePeakVE/VCO2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e50.61(44.41,60.00)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New 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\u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-8.48\u0026plusmn;18.71\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.906\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eOUEP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e24.50\u0026plusmn;3.99\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e26.77\u0026plusmn;3.59\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.146\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e3.08\u0026plusmn;2.65\u003c/span\u003e\u003c/p\u003e\n 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eSLOPE\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e47.29(42.73,57.60)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e40.46\u0026plusmn;6.04\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.017\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-10.44\u0026plusmn;11.00\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e-3.49\u0026plusmn;5.97\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.093\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:87.4pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003eOUES\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:90.45pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e996.54\u0026plusmn;234.85\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e1227.3\u0026plusmn;419.43\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.8pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.037\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:3.0cm;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e147.09\u0026plusmn;257.89\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:77.95pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e33.58\u0026plusmn;402.48\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:45.45pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:15.0pt;'\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e0.317\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003eSee Table 2 legend for expansion of abbreviations.\u003c/p\u003e\n\u003cp\u003eA ssociations between FeNO levels and clinical parameters at baseline and after balloon pulmonary angioplasty BPA\u003c/p\u003e\n\u003cp\u003eThe relationship between FeNO levels and clinical parameters in patients with CTEPH was evaluated, stratified by FeNO thresholds, both at baseline and following BPA. These findings, presented in Table 4, reveal distinct patterns of association that may inform personalized treatment strategies and deepen our understanding of CTEPH pathophysiology. For the cardiac stress biomarker NT-proBNP, patients in the FeNO \u0026lt;25 ppb group exhibited a weak negative correlation at baseline (R = -0.110, p = 0.466) and a very weak positive correlation post-BPA (R = 0.029, p = 0.846). The FeNO \u0026ge;25 ppb group showed a no correlation at baseline (R = 0.284, p = 0.398) and post-BPA (R = -0.348, p = 0.295); Pulmonary function tests revealed notable differences in gas exchange efficiency as measured by DLCO. In the FeNO \u0026lt;25 ppb group, a no correlation was observed at baseline (R = -0.121, p = 0.429), while a moderate negative correlation post-BPA (R = -0.340, p = 0.021) indicated that higher baseline FeNO levels were associated with less improvement in DLCO following treatment. Conversely, the FeNO \u0026ge;25 ppb group demonstrated a strong negative correlation at baseline (R = -0.650, p = 0.030), linking elevated FeNO levels to compromised baseline gas exchange efficiency, possibly indicative of microvascular dysfunction. Post-BPA, a weak positive correlation (R = 0.279, p = 0.406) showed no significant relationship with treatment-induced DLCO changes. FVC showed no statistically significant correlations in either subgroup at baseline or post-BPA (all p \u0026gt; 0.05). Hemodynamic assessments revealed heterogeneous responses based on FeNO stratification. In the FeNO \u0026lt;25 ppb group, there is no correlation between FENO and baseline mPAP(R = 0.099, p = 0.513), a significant negative correlation was observed in post-BPA changes in mPAP (R = -0.293, p = 0.048) (Figure. 4A-B), demonstrating that patients with lower baseline FeNO levels experienced smaller mPAP reductions after BPA. In the FeNO\u0026ge;25 ppb subgroup, FeNO shows no correlation with either baseline mPAP (R = -0.058, p = 0.866) or mPAP change (R = -0.090, p = 0.793) (Figure. 4C-D), suggesting differential hemodynamic responsiveness. LVES analysis in the FeNO \u0026lt;25 ppb group revealed a strong positive correlation at baseline (R = 0.354, p = 0.016), implying that higher FeNO levels were associated with adverse left ventricular remodeling, potentially reflecting increased afterload or biventricular dysfunction. Post-BPA, a negative correlation (R = -0.259, p = 0.083) indicated a trend toward LVES reduction in patients with lower baseline FeNO, though statistical significance was not reached. Exercise capacity parameters showed no significant correlations in either FeNO subgroup.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eTable 4. Correlation Analysis of Baseline and Post-Treatment Changes in Clinical Parameters Stratified by FeNO levels.\u003c/p\u003e\n\u003cdiv style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:115%;font-size:15px;font-family:\"Times New Roman\",serif;'\u003e\n \u003ctable style=\"border: none;width:505.05pt;border-collapse:collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.35pt;border-top:solid black 1.0pt;border-left: none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eFactors\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:101.9pt;border-top:solid black 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eBaseline\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:107.6pt;border-top:solid black 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eChange\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:107.6pt;border-top:solid black 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eBaseline\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"2\" style=\"width:107.6pt;border-top:solid black 1.0pt;border-left:none;border-bottom:solid black 1.0pt;border-right:none;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eChange\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.35pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eR\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eR\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eR\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eR\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:15.75pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eP\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.35pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:209.5pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eFeNO\u0026lt;25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"4\" style=\"width:215.2pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eFeNO\u0026ge;25\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.35pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eNT-proBNP,\u003c/span\u003e\u003cspan style=\"font-size:10px;line-height:150%;\"\u003e\u0026nbsp;pg/mL\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.110\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.466\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.029\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.846\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.284\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.398\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.348\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.295\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New 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style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.4pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.35pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.245\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.467\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.35pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.15pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eFVC% predicted\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.15pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.132\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.15pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.382\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.494\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.15pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.122\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.15pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.352\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:30.15pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.288\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.35pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eFEV1, 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5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.091\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.548\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.188\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.212\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.628\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.35pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eFEV1/FVC% predicted\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.35pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003ePAP systolic, mm Hg\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.063\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.675\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.047\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.447\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.311\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.352\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.35pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eRight atrium, cm\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.289\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;color:red;\"\u003e0.051\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.171\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.256\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.227\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.502\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.060\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.861\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.918\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.095\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.530\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.512\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.108\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.231\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.122\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.280\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.404\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.443\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.173\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.35pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003eRVP, mmHg\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.193\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.200\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.035\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.818\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.098\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.787\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.396\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.228\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.35pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003emPAP, mmHg\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.099\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.513\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.293\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;color:red;\"\u003e0.048\u003c/span\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.058\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.866\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.090\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.793\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:80.35pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003ePAWP, mmHg\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:48.1pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.054\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.722\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.143\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.342\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.127\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New 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style=\"width:53.8pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.152\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.375\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e-0.253\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.545\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.229\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:53.8pt;border:none;border-bottom:solid black 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:20.25pt;\"\u003e\n \u003cp style='margin-top:0cm;margin-right:0cm;margin-bottom:8.0pt;margin-left:0cm;line-height:150%;font-size:15px;font-family:\"Times New Roman\",serif;text-align:justify;text-indent:13.0pt;'\u003e\u003cspan style=\"font-size:9px;line-height:150%;\"\u003e0.586\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n \u003c/table\u003e\n\u003c/div\u003e\n\u003cp\u003eCorrelation coefficients were expressed as Pearson or Spearman correlation coefficients. See Table 2 legend for expansion of abbreviations.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThis study pioneers the systematic investigation of FeNO dynamics following BPA in patients with inoperable CTEPH, establishing baseline FeNO as a robust predictive biomarker for treatment response. By stratifying patients using a 25 ppb FeNO cutoff, we identified two distinct phenotypic responses: the FeNO \u0026lt; 25 ppb cohort exhibited significant post-BPA FeNO elevation alongside comprehensive improvements in pulmonary function, cardiac structure-function, hemodynamics, and cardiopulmonary exercise capacity; in contrast, the FeNO\u0026nbsp;\u0026ge;\u0026nbsp;25 ppb group demonstrated isolated hemodynamic benefits without meaningful changes in FeNO or pulmonary function.This discovery not only provides a new biomarker for the individualized evaluation of BPA treatment efficacy but also offers key evidence for an in-depth understanding of the association between the pathophysiological mechanisms of CTEPH and the therapeutic benefits of BPA.\u003c/p\u003e\n\u003cp\u003eAssociation between Dynamic Changes in FeNO and BPA Treatment Response and Mechanistic Exploration. 1. In the FeNO \u0026lt; 25 ppb subgroup (n=46), post-BPA FeNO increased from 13.96\u0026plusmn;5.37 to 19.89\u0026plusmn;8.20 ppb (P\u0026lt;0.001), coinciding with significant improvements in forced vital capacity (FVC: 2.57 vs. 2.76 L, P=0.006), left ventricular end-systolic diameter (LVES: 4.22 vs. 4.86 cm, P\u0026lt;0.001), mean pulmonary arterial pressure (mPAP: 43.65 vs. 26.96 mmHg, P\u0026lt;0.001), and peak oxygen uptake (PeakV\u0026apos;O2: 843.11 vs. 967.39 mL/min, P=0.019). This synergy strongly suggests FeNO elevation reflects restored endothelial nitric oxide synthase (eNOS)-mediated NO production. Pathophysiologically, CTEPH is characterized by macrovascular thrombo-occlusion and secondary microvascular remodeling, both of which impair endothelial oxygenation and eNOS activity[27].BPA reverses this by dilating occluded segmental/sub-segmental arteries (6\u0026ndash;14 vessels per session), restoring pulmonary blood flow and reducing shear stress on endothelial cells[28]. Preclinical studies have shown that improved endothelial oxygenation downregulates oxidative stress markers (e.g., malondialdehyde) and upregulates eNOS phosphorylation[29], directly increasing NO bioavailability. Our observation of a negative correlation between baseline FeNO and post-BPA mPAP change (R=-0.293, P=0.048) aligns with this: lower baseline FeNO likely indicates more severe pre-existing eNOS dysfunction, and BPA-induced hemodynamic normalization drives a more pronounced NO synthesis rebound [22]. Notably, DLCO remained unchanged in this subgroup (P=0.243), consistent with prior reports that DLCO serves as a marker of irreversible microvascular damage in CTEPH [30]. However, the negative correlation between baseline FeNO and post-BPA DLCO change (R=-0.340, P=0.021) suggests that FeNO may still capture subtle microvascular recovery\u0026mdash;an effect not detectable by standard DLCO metrics. 2. The FeNO\u0026nbsp;\u0026ge;\u0026nbsp;25 ppb subgroup (n=11) displayed a fundamentally different response: while PVR decreased significantly (5.33 vs. 3.03 Wood units, P=0.003), FeNO remained stable (30 vs. 29 ppb, P=0.110) and pulmonary function (e.g., FVC: 2.89 vs. 2.93 L, P=0.527) and NT-proBNP (159.3 vs. 75.6 pg/mL, P=0.123) showed no meaningful improvements. This dissociation highlights the limitations of BPA in addressing non-macrovascular components of CTEPH pathophysiology. Two key mechanistic explanations emerge. First, baseline hemodynamics in this subgroup were less severe (mPAP: 36 vs. 43.65 mmHg, P=0.047; PVR: 5.33 vs. 7.78 Wood units, P=0.022)[31], leaving less room for BPA-mediated improvement. Second, the strong negative correlation between baseline FeNO and DLCO (R=-0.650, P=0.030) suggests elevated FeNO reflects underlying microvascular inflammation\u0026mdash;likely driven by inducible nitric oxide synthase (iNOS) upregulation\u0026mdash;rather than isolated eNOS dysfunction[32].Unlike eNOS, iNOS is induced by pro-inflammatory cytokines (e.g., TNF-\u0026alpha;, IL-6) in response to microvascular injury, and its activity is unaffected by macrovascular recanalization[27]. This is supported by prior work showing iNOS-derived NO contributes to \u0026quot;dysfunctional\u0026quot; FeNO elevation in pulmonary hypertension with microvascular involvement[33]. The isolated improvement in oxygen uptake efficiency plateau (OUEP: 26.77 vs. 31.04, P=0.012) further reinforces this phenotype: OUEP reflects metabolic efficiency rather than cardiopulmonary reserve, suggesting BPA only optimizes oxygen delivery to pre-existing functional microvasculature without addressing inflammatory microvascular damage [11].\u003c/p\u003e\n\u003cp\u003eClinical Value of FeNO as a Predictive Biomarker for BPA Treatment Response. 1. Current CTEPH guidelines rely on imaging (e.g., CTPA, V/Q scintigraphy) and right heart catheterization (RHC) to select BPA candidates, but these do not capture endothelial or microvascular status[1]. Our data show FeNO \u0026lt; 25 ppb predicts superior multi-domain response: compared to FeNO\u0026nbsp;\u0026ge;\u0026nbsp;25 ppb, this group had larger improvements in FeNO (P=0.001), LVED (P=0.033), LVES (P=0.035), and mPAP (P=0.014). FeNO\u0026rsquo;s advantages\u0026mdash;non-invasiveness, low cost, and alignment with ATS/ERS standardization[34]\u0026mdash;make it ideal for integrating into pre-BPA workups. For example, FeNO \u0026lt; 25 ppb could identify patients most likely to benefit from BPA, while FeNO\u0026nbsp;\u0026ge;\u0026nbsp;25 ppb may prompt consideration of adjunctive therapies (e.g., anti-inflammatories, targeted microvascular agents)[28]. 2. Complementarity with Existing Biomarkers FeNO fills critical gaps in current biomarker panels. NT-proBNP, a marker of cardiac stress, only correlated with response in the FeNO \u0026lt; 25 ppb group (P\u0026lt;0.001 vs. P=0.123)[33], failing to capture microvascular status. DLCO, though a microvascular marker, showed no post-BPA improvement in either subgroup (P\u0026gt;0.240) [31], limiting its utility for monitoring. FeNO, by contrast, integrates both endothelial function (eNOS) and inflammation (iNOS) signals: a post-BPA FeNO increase confirms eNOS restoration, while stable elevated FeNO flags unaddressed microvascular inflammation. This dual utility was exemplified by our finding that FeNO\u0026nbsp;\u0026ge;\u0026nbsp;25 ppb patients with low DLCO may benefit from combined BPA and anti-inflammatory therapy\u0026mdash;an insight unobtainable with NT-proBNP or DLCO alone[35].\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThe innovation points of this study are noteworthy and can be highlighted as follows: 1. This study is the first systematic investigation into the dynamic changes in FeNO before and after BPA treatment in patients with inoperable CTEPH, filling a gap in the field of research. 2. By stratifying using a baseline FeNO threshold of 25 ppb, two distinct treatment response phenotypes were identified: patients with FeNO \u0026lt; 25 ppb showed comprehensive improvement in multiple functional dimensions postoperatively, while those with FeNO \u0026ge; 25 ppb exhibited only partial hemodynamic improvement. 3. The predictive value of FeNO was confirmed: in the FeNO \u0026lt; 25 ppb group, baseline FeNO was negatively correlated with postoperative mPAP improvement, indicating that FeNO can serve as a predictive biomarker for the efficacy of BPA treatment. Limitations: 1 Study Limitations: This study has three key limitations. First, the single-center, small sample size (n=57; FeNO \u0026ge; 25 ppb, n=11) raises concerns about selection bias and statistical power, particularly for subgroup analyses. Second, unmeasured confounders\u0026mdash;including nitrate intake (which affects FeNO), upper respiratory infections (which upregulate iNOS), and concurrent medications (e.g., riociguat, which modulates NO)\u0026mdash;may have influenced results. Third, lack of long-term follow-up (e.g., 12\u0026ndash;24 months) prevents assessment of FeNO\u0026rsquo;s prognostic value for hard outcomes (e.g., right heart failure, mortality). Finally, we did not measure eNOS/iNOS expression or NO metabolites (e.g., nitrite), limiting direct mechanistic validation.\u0026nbsp;\u003c/p\u003e"},{"header":"Conclusion ","content":"\u003cp\u003eThis study establishes baseline FeNO as a clinically actionable biomarker for BPA response in inoperable CTEPH. Patients with FeNO \u0026lt; 25 ppb derive comprehensive benefits from BPA, reflecting restored eNOS-mediated NO production and macrovascular-microvascular synergy. In contrast, FeNO \u0026ge; 25 ppb identifies a phenotype with isolated hemodynamic response, likely due to unaddressed iNOS-driven microvascular inflammation. These findings advocate for FeNO-guided personalized care: FeNO \u0026lt; 25 ppb prioritizes BPA, while FeNO \u0026ge; 25 ppb warrants BPA plus adjunctive therapy. Future work to validate FeNO in larger cohorts and explore targeted therapies for high-FeNO patients will further advance CTEPH precision medicine.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cdiv class=\"DefinitionList\"\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eBNP\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003ebrain natriuretic peptide\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eFeNO\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003efractional exhaled nitric oxide\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003ePFT\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003epulmonary function tests\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eFVC\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eforced vital capacity\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eFEV1\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eforced expiratory volume in 1 s\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eTLC\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003etotal lung capacity\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eDLCO\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003ediffusing capacity of the lung for carbon monoxide\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003ePAP\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003epulmonary artery pressure\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eRHC\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eRight heart catheterization\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003ePVR\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003epulmonary vascular resistance\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003ePAWP\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003epulmonary artery wedge pressure\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eCO\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eCardiac output\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eRAP\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eRight atrial pressure\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eRVP\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eRight ventricular pressure\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eCI\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eCardiac input\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eCPET\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003ecardiopulmonary exercise testing\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eV'O2\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eOxygen uptake\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eV'CO2\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eCarbon dioxide output\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eVE/VCO2\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eVentilation/Carbon dioxide output\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eOUEP\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eOxygen Uptake Efficiency Plateau\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eOUES\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eOxygen Uptake Efficiency Slope\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eTTE\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003etransthoracic echocardiography\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eLVED\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eLeft ventricle end-diastolic diameter\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eLVES\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eLeft ventricle end-systolic diameter\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eTAPSE\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003etricuspid annular plane systolic excursion. BMI:body mass index\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eWHO\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eWorld Health Organization\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eNOS\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003enitric oxide synthase\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eCOPD\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eChronic Obstructive Pulmonary Disease\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003c/div\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll patients in this study were informed at admission that their medical records were likely to be used for clinical studies. Ethical approval by the medical ethics committee of Shanghai pulmonary hospital was obtained.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll the related data are presented in the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors confirm that there are no conflicts of interest\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was supported by the Scientific research project of Shanghai Municipal Health Commission [202040321] and the Clinical research project of Shanghai Pulmonary Hospital\u0026nbsp;[FKLY20020].\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eContributorship statement\u003c/strong\u003e\u003cstrong\u003e：\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eConceived and designed the experiments: JHX JG.\u003c/p\u003e\n\u003cp\u003ePerformed the experiments: XXS YC WLY TRZ.\u003c/p\u003e\n\u003cp\u003eAnalyzed the data: JHX MH XXS JG.\u003c/p\u003e\n\u003cp\u003eContributed reagents/materials/analysis tools: JHX JML HQZ.\u003c/p\u003e\n\u003cp\u003eWrote the paper: JHX MH JG.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003eHumbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. 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Br J Pharmacol. 2007;150(4):494\u0026ndash;501.\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"FeNO, CTEPH, BPA, Clinical correlation","lastPublishedDoi":"10.21203/rs.3.rs-8420176/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-8420176/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eBalloon pulmonary angioplasty (BPA) has been confirmed to improve ventilatory efficiency and pulmonary gas exchange in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH), yet the underlying mechanisms driving these improvements remain poorly elucidated. Nitric oxide (NO), as a key endothelium-derived vasodilator, plays a critical role in regulating pulmonary vascular tone and endothelial function. Against this backdrop, the present study aimed to investigate the dynamic changes in fractional exhaled nitric oxide (FeNO) levels following BPA and clarify its correlation with a panel of clinical and functional parameters in this patient population.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003eA prospective cohort of 57 patients diagnosed with inoperable CTEPH was recruited from Shanghai Pulmonary Hospital Affiliated to Tongji University. Comprehensive clinical assessments, including measurements of FeNO, N-terminal pro-brain natriuretic peptide (NT-proBNP), pulmonary function tests (PFT), transthoracic echocardiography (TTE), cardiopulmonary exercise testing (CPET), and right heart catheterization (RHC), were conducted both before BPA treatment and after the completion of the intervention course.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003ePatients were stratified into two subgroups based on baseline FeNO levels: FeNO\u0026thinsp;\u0026lt;\u0026thinsp;25 ppb (n\u0026thinsp;=\u0026thinsp;46) and FeNO\u0026thinsp;\u0026ge;\u0026thinsp;25 ppb (n\u0026thinsp;=\u0026thinsp;11). Key findings were as follows: 1. FeNO levels increased significantly in the FeNO\u0026thinsp;\u0026lt;\u0026thinsp;25 ppb group after BPA (P\u0026thinsp;\u0026lt;\u0026thinsp;0.001), whereas no statistically significant change was observed in the FeNO\u0026thinsp;\u0026ge;\u0026thinsp;25 ppb group (P\u0026thinsp;=\u0026thinsp;0.110). 2. In the FeNO\u0026thinsp;\u0026lt;\u0026thinsp;25 ppb group, notable improvements were achieved in pulmonary function, cardiac structure and function, hemodynamic indices, and cardiopulmonary exercise capacity post-BPA; in contrast, the FeNO\u0026thinsp;\u0026ge;\u0026thinsp;25 ppb group exhibited improvements in cardiac function, hemodynamics, and cardiopulmonary exercise capacity, but no significant changes in pulmonary function parameters. 3. Correlation analysis revealed that baseline FeNO levels in the FeNO\u0026thinsp;\u0026lt;\u0026thinsp;25 ppb group were negatively correlated with post-treatment changes in diffusing capacity of the lung for carbon monoxide (DLCO) and mean pulmonary artery pressure (mPAP), and positively correlated with baseline left ventricular end-systolic diameter (LVES); for the FeNO\u0026thinsp;\u0026ge;\u0026thinsp;25 ppb group, baseline FeNO levels were negatively correlated with baseline DLCO values. 4. No significant differences in baseline pulmonary function and cardiac function were detected between the two subgroups; however, the FeNO\u0026thinsp;\u0026lt;\u0026thinsp;25 ppb group presented with higher baseline mPAP, pulmonary vascular resistance (PVR), and VE/VCO2 slope (SLOPE), as well as lower baseline oxygen uptake efficiency slope (OUES). Moreover, the magnitude of improvements in LVED, LVES, and mPAP was more pronounced in the FeNO\u0026thinsp;\u0026lt;\u0026thinsp;25 ppb group.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eFeNO levels can serve as a reliable predictive biomarker for treatment response to BPA in CTEPH patients. Those with lower baseline FeNO levels tend to be more suitable candidates for BPA and achieve more comprehensive clinical benefits, while patients with higher FeNO levels may require adjunctive therapeutic strategies to optimize their treatment outcomes.\u003c/p\u003e","manuscriptTitle":"Predictive Value and Clinical Correlation of Baseline FeNO Levels for Balloon Pulmonary Angioplasty Efficacy in Patients with Inoperable chronic thromboembolic pulmonary hypertension","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-01-22 14:17:41","doi":"10.21203/rs.3.rs-8420176/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"23546bfb-a325-4d34-b62b-824767e171ab","owner":[],"postedDate":"January 22nd, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-02-16T09:34:27+00:00","versionOfRecord":[],"versionCreatedAt":"2026-01-22 14:17:41","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8420176","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8420176","identity":"rs-8420176","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}