A Novel WNK1-PDGFRB Fusion Gene in Myeloid Neoplasm With Eosinophilia: A Case Report With a Literature Review

Platelet-derived growth factor receptor beta (PDGFRB) rearrangements play an important role in the pathogenesis of eosinophilia-associated myeloid/lymphoid neoplasms. Here, a novel WNK1-PDGFRB fusion gene has been identified in myeloid neoplasm with eosinophilia by RNA-sequencing. This is the first study that reported on the WNK1-PDGFRB fusion gene expression in myeloid neoplasm with eosinophilia. In addition, the WNK1-PDGFRB fusion retained the entire kinase domain of PDGFRB and response to imatinib at low concentration.