Prevalence and Antimicrobial Susceptibility pattern of pathogens Isolated from different age groups with Urinary Tract Infection in Bangladesh

Abstract Background: Urinary tract infections (UTIs) are a common nosocomial infection in many hospitals and routine clinical practices. Contemporary knowledge of pathogens and their pattern of antibiotic susceptibility is essential for updating antibiotic policy. Methods: This study was designed to determine the prevalence of microorganisms that cause urinary tract infections and to determine their antibiotic susceptibility pattern.A total of 1288 clinical samples were aseptically collected from UTI patients. After collection, pathogenic bacteria was isolated and identified with biochemical tests. Their antimicrobial susceptibility pattern was determined by Kirby–Bauer disc diffusion method using 14 commercial antibiotics. Results: Out of 1288 samples, 398 samples showed positive growth with various pathogens. Further analysis of samples presented a high prevalence of UTI in female than male. Identified pathogens were mostly E. coli (82.41%) followed by Enterococcus faecalis, Klebsiella sp, Pseudomonas aeruginosa and Proteus sp.. Most of the bacteria showed high (≥ 98.25%) sensitivity to Meropenem; moderate susceptibility to Amoxicillin, Azithromycin, Ciprofloxacin, Gentamicin, Levofloxacin, Ceftriaxone, Cefepime and Nitrofurantoin and least (<20%) sensitivity to Cefixime, Cephradine, Cefuroxime, Clindamycin, and Trimethoprime. Conclusion: These results are of clinical and epidemiological significance, enhancing the studies to identify causative pathogens and sensitivity patterns of pathogens in UTIs, as well as improving clinicians’ knowledge of how to select the best antibiotics and ultimately contribute to the diagnosis and treatment of patients.