Utility of some ICD 10th revision codes for detecting serious and interesting ADR.

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Abstract

Aim: Efforts to mitigate underreporting have focused on the ability of different methods, independent of spontaneous reporting, to identify ADRs. However, there is limited data on the effectiveness of these methods in detecting ADRs of interest. In this study, we collected data on this issue using the ICD-10 codes we routinely employ to detect unreported ADRs. Methods: We defined ADRs of interest as those that were severe, involved biological agents or drugs under additional monitoring, affected a child, and were previously unknown, while providing sufficient data on both the reaction and the drug. We generated a list of all patients whose discharge reports included any of the selected codes. The medical records of these patients were manually reviewed to verify the presence of an ADR and determine whether it met the criteria for being of interest. Results: We observed a significant difference between a code’s ability to detect ADRs and its effectiveness in identifying ADRs of interest. Of the 50 codes analysed, 17 were useful in identifying ADRs of interest. Conclusions: There isn‘t a small set of codes that allow to identify interesting ADRs nor any ADR related code identifies an interesting ADR every time it appears. Every unit going to use this method to identify ADRs should previously explore the utility of each code, although the codes proposed by us seems to be a good starting point.
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Utility of some ICD 10th revision codes for detecting serious and interesting ADR. | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 13 March 2025 V1 Latest version Share on Utility of some ICD 10th revision codes for detecting serious and interesting ADR. Authors : Carlos Boada Fernández del Campo 0000-0002-1087-9018 [email protected] , Eduardo Fernández Quintana , Marcelino García Sanchez-Colomer , and Damian Fondevilla Batista Authors Info & Affiliations https://doi.org/10.22541/au.174185477.71378154/v1 241 views 137 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Aim: Efforts to mitigate underreporting have focused on the ability of different methods, independent of spontaneous reporting, to identify ADRs. However, there is limited data on the effectiveness of these methods in detecting ADRs of interest. In this study, we collected data on this issue using the ICD-10 codes we routinely employ to detect unreported ADRs. Methods: We defined ADRs of interest as those that were severe, involved biological agents or drugs under additional monitoring, affected a child, and were previously unknown, while providing sufficient data on both the reaction and the drug. We generated a list of all patients whose discharge reports included any of the selected codes. The medical records of these patients were manually reviewed to verify the presence of an ADR and determine whether it met the criteria for being of interest. Results: We observed a significant difference between a code’s ability to detect ADRs and its effectiveness in identifying ADRs of interest. Of the 50 codes analysed, 17 were useful in identifying ADRs of interest. Conclusions: There isn‘t a small set of codes that allow to identify interesting ADRs nor any ADR related code identifies an interesting ADR every time it appears. Every unit going to use this method to identify ADRs should previously explore the utility of each code, although the codes proposed by us seems to be a good starting point. Supplementary Material File (main text icd bjcp.docx) Download 36.84 KB File (table 1 icd bjcp.odt) Download 30.50 KB File (table 2 icd bjcp.odt) Download 33.93 KB File (table 3 icd bjcp.odt) Download 15.23 KB File (table 4 icd bjcp.odt) Download 12.39 KB File (table 5 icd bjcp.odt) Download 17.49 KB File (table 6 icd bjcp.odt) Download 35.17 KB Information & Authors Information Version history V1 Version 1 13 March 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords adverse drug reactions clinical pharmacology drug safety epidemiology medication safety pharmacovigilance Authors Affiliations Carlos Boada Fernández del Campo 0000-0002-1087-9018 [email protected] Hospital Universitario de Canarias View all articles by this author Eduardo Fernández Quintana Centro Autonómico de Farmacovigilancia e Información Terapéutica de Canarias View all articles by this author Marcelino García Sanchez-Colomer Centro Autonómico de Farmacovigilancia e Información Terapéutica de Canarias. View all articles by this author Damian Fondevilla Batista Hospital Universitario de Canarias View all articles by this author Metrics & Citations Metrics Article Usage 241 views 137 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Carlos Boada Fernández del Campo, Eduardo Fernández Quintana, Marcelino García Sanchez-Colomer, et al. Utility of some ICD 10th revision codes for detecting serious and interesting ADR.. Authorea . 13 March 2025. 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