Colorectal cancer risk following appendectomy: a pooled analysis of three large prospective cohort studies.

Rothwell JA, Mori N, Artaud F, A. Fournier, Conte M, Boutron-Ruault MC, Chan SSM, Marc J. Gunter, Murphy N, Severi G
Cancer communications (London, England) · 2022 · doi:10.1002/cac2.12265 · PMID:35132829 · PMC9118062
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A pooled analysis of three large prospective cohort studies examined the association between colorectal cancer risk and prior appendectomy status among participants from the UK Biobank, EPIC, and E3N cohorts.

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This pooled analysis of three large prospective cohort studies investigated the association between appendectomy and subsequent colorectal cancer risk. The researchers utilized data from the UK Biobank, EPIC, and E3N cohorts to evaluate this potential link while controlling for various confounding factors. The study found no significant increase in colorectal cancer risk among individuals who had undergone an appendectomy compared to those who had not. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Declarations

N.Murphy and GS, conceptualization of the study; JAR, NM, FA, data analysis; JAR, writing of the manuscript; AF, MC, MCBR, SSMC, MJG, reviewing and editing of the manuscript, and advice on interpretation of results; N.Murphy and GS, study supervision. The UK Biobank obtained approval from the North‐West Multicenter Research Ethics Committee, the National Information Governance Board for Health and Social Care in England and Wales, and the Community Health Index Advisory Group in Scotland. Ethical approval for the EPIC study was obtained from the International Agency for Research on Cancer and the ethical review boards of the participating institutes. The cohort was granted ethical approval by the French National Commission for Computed Data and Individual Freedom (Commission Nationale de l'Informatique et des Libertés). All participants from each of the three cohorts provided written informed consent. Not applicable. The French E3N cohort is maintained with the support of the Mutuelle Générale de l'Education Nationale (MGEN), Gustave Roussy and the French League against Cancer (LNCC). E3N‐E4N is also supported by the French National Research Agency (ANR) under the Investment for the future Program (PIA) (ANR‐10‐COHO‐0006) and by the French Ministry of Higher Education, Research and Innovation (subsidy #2102 918823). This work has been supported within the context of the ALLERCOLO project funded by Fondation ARC. The authors declare there are no conflicts of interest.

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