Alterations in cerebral perfusion and corresponding brain functional networks in systemic lupus erythematosus with cognitive impairment

Alterations in cerebral perfusion and corresponding brain functional networks in systemic lupus erythematosus with cognitive impairment | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Alterations in cerebral perfusion and corresponding brain functional networks in systemic lupus erythematosus with cognitive impairment Huiyang Liu, Hu Liu, Bailing Tian, Pingting Yang, Guoguang Fan This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4604351/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 08 Jan, 2025 Read the published version in Scientific Reports → Version 1 posted 10 You are reading this latest preprint version Abstract Cognitive impairment (CI) frequently occurs in patients with systemic lupus erythematosus (SLE) and may result from neuroinflammation processes and neurovascular changes in the brain. The cerebral hemodynamics underlying SLE with CI (SLE-CI) remain unclear. 97 patients with SLE and 51 heathy controls (HCs) matched for age and gender underwent magnetic resonance imaging (MRI). The CI status of patients was measured using the Montreal Cognitive Assessment (MoCA). 3D T1-weighted arterial spin labeling (ASL) and resting-state functional (rs-fMRI) sequences were obtained. Seed-based FC was calculated using the CBF results. Compared with patients with SLE-NC, patients with SLE-CI had higher CBF in the left hippocampus, thalamus, and cerebellum crus II and lower CBF in the left frontal lobe. Left hippocampus gray matter (GM) atrophy was detected in patients with SLE-CI but not in patients with SLE-NC. Secondary analyses revealed that compared with patients with SLE-NC, patients with SLE-CI had increased FC of the left insula gyrus when the left cerebellum crus II was set as the seed region and decreased FC in the homolateral parahippocampus when the left hippocampus was set as the seed region. These changes in brain structure, function, and network may be biomarkers of cognitive impairment in patients with SLE-CI. Biological sciences/Immunology/Imaging the immune system Biological sciences/Immunology/Inflammation Biological sciences/Immunology/Neuroimmunology neuropsychiatric systemic lupus cognitive impairment arterial spin labeling functional connectivity Full Text Additional Declarations No competing interests reported. Supplementary Files SupplementaryFigure1.docx Cite Share Download PDF Status: Published Journal Publication published 08 Jan, 2025 Read the published version in Scientific Reports → Version 1 posted Editorial decision: Revision requested 11 Nov, 2024 Reviews received at journal 08 Nov, 2024 Reviewers agreed at journal 30 Oct, 2024 Reviews received at journal 07 Sep, 2024 Reviewers agreed at journal 05 Aug, 2024 Reviewers invited by journal 16 Jul, 2024 Editor assigned by journal 16 Jul, 2024 Editor invited by journal 02 Jul, 2024 Submission checks completed at journal 27 Jun, 2024 First submitted to journal 19 Jun, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4604351","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":328870499,"identity":"6fade511-584d-4e8b-9458-a852ab5fc7c6","order_by":0,"name":"Huiyang Liu","email":"","orcid":"","institution":"First Hospital of China Medical University","correspondingAuthor":false,"prefix":"","firstName":"Huiyang","middleName":"","lastName":"Liu","suffix":""},{"id":328870501,"identity":"8baea8ed-146b-4a1f-857b-a63fb70f25f2","order_by":1,"name":"Hu Liu","email":"","orcid":"","institution":"First Hospital of China Medical 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lupus, cognitive impairment, arterial spin labeling, functional connectivity","lastPublishedDoi":"10.21203/rs.3.rs-4604351/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4604351/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Cognitive impairment (CI) frequently occurs in patients with systemic lupus erythematosus (SLE) and may result from neuroinflammation processes and neurovascular changes in the brain. 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